Doxorubicin: Comparison between 3-h continuous and bolus intravenous administration paradigms on cardio-renal axis, mitochondrial sphingolipids and pathology

Kamendi, Harriet; Zhou, Ying; Crosby, Meredith E.; Keirstead, Natalie D.; Snow, Debra; Bentley, Patricia; Patel, Nilaben; Barthlow, Herbert; Luo, Wei; Dragan, Yvonne P.; Bialecki, Russell

doi:10.1016/j.taap.2015.10.002

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…This interpretation from a mathematical modeling perspective can also be corroborated by an earlier independent research finding from DOX-treated mice through pathway and biochemical analyses (Pointon et al, 2010), whereas direct mtDNA damage triggered by DOX is responsible for chronic cardiotoxicity at therapeutic doses, leading to further irreversible mitochondrial dysfunction. (Pacciarini et al, 1978), rat (Yeung et al, 2002;Kamendi et al, 2015), human (Weiss and Manthel, 1977;Chlebowski et al, 1980;Legha et al, 1982a;Torti et al, 1983) Dose (Forssen and Tökès, 1981;Kanter et al, 1993b), beagle dog (Herman et al, 1983;Kanter et al, 1993a;Working et al, 1999), rabbit (Working et al, 1999), human (Berry et al, 1998;Lotem et al, 2000;Lyass et al, 2000;Safra et al, 2000;O'Brien et al, 2004) Stomatitis is another major toxic effect observed (Lyu et al, 2007;Deng et al, 2014), mouse…”

Section: Molecular Mechanisms Of Dicmentioning

confidence: 99%

Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

et al. 2019

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Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity. Despite the enormous amount of research conducted in this area, the exact molecular mechanisms underlying DOX toxic effects on the heart are still an area that warrants further investigations. In this study, we reviewed literature to gather the best-known molecular pathways related to DOX-induced cardiotoxicity (DIC). They include mechanisms dependent on mitochondrial dysfunction such as DOX influence on the mitochondrial electron transport chain, redox cycling, oxidative stress, calcium dysregulation, and apoptosis pathways. Furthermore, we discuss the existing strategies to prevent and/or alleviate DIC along with various techniques available for therapeutic drug monitoring (TDM) in cancer patients treated with DOX. Finally, we propose a stepwise flowchart for TDM of DOX and present our perspective at curtailing this deleterious side effect of DOX.

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Section: Molecular Mechanisms Of Dicmentioning

confidence: 99%

Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

et al. 2019

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“… 73 Anthracyclines (ANTs) are cancer drugs effectively used for treating malignant neoplasms. 135 Doxorubicin, an amphiphilic drug with small molecular weight, 136 , 137 is an effective ANT antibiotic 27 , 138 used for the treatment of multiple types of cancers. Doxorubicin’s advantages include high response rate, increased time to disease progression and low therapeutic index.…”

Section: Functionalization and Applications Of Nanoparticles In Chemomentioning

confidence: 99%

“… 148 Doxorubicin interacts with dsDNA and nucleic acids, causing single- and double-strand breaks, but at the same time, it increases cell membrane permeability and inactivates membrane receptors. 135 Damage induced by free radicals affects the heart through high oxidative metabolism and low level of antioxidant defenses, and regarding the liver, free radicals induce cell death and tissue damage. 143 Through active internalization, doxorubicin exhibits accelerated intracellular trafficking in vivo.…”

Section: Functionalization and Applications Of Nanoparticles In Chemomentioning

confidence: 99%

The new era of nanotechnology, an alternative to change cancer treatment

Jurj

Braicu

Pop

et al. 2017

DDDT

153

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In the last few years, nanostructures have gained considerable interest for the safe delivery of therapeutic agents. Several therapeutic approaches have been reported, such as molecular diagnosis, disease detection, nanoscale immunotherapy and anticancer drug delivery that could be integrated into clinical use. The current paper aims to highlight the background that supports the use of nanoparticles conjugated with different types of therapeutic agents, applicable in targeted therapy and cancer research, with a special emphasis on hematological malignancies. A particular key point is the functional characterization of nonviral delivery systems, such as gold nanoparticles, liposomes and dendrimers. The paper also presents relevant published data related to microRNA and RNA interference delivery using nanoparticles in cancer therapy.

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Comparison of bolus administration and short-term infusion versus long-term infusion of doxorubicin in terms of cardiotoxicity and efficacy

Ghiami,

Omidkhoda,

Seddigh-Shamsi

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Doxorubicin: Comparison between 3-h continuous and bolus intravenous administration paradigms on cardio-renal axis, mitochondrial sphingolipids and pathology

Cited by 6 publications

References 42 publications

Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring

The new era of nanotechnology, an alternative to change cancer treatment

Comparison of bolus administration and short-term infusion versus long-term infusion of doxorubicin in terms of cardiotoxicity and efficacy

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