“…This interpretation from a mathematical modeling perspective can also be corroborated by an earlier independent research finding from DOX-treated mice through pathway and biochemical analyses (Pointon et al, 2010), whereas direct mtDNA damage triggered by DOX is responsible for chronic cardiotoxicity at therapeutic doses, leading to further irreversible mitochondrial dysfunction. (Pacciarini et al, 1978), rat (Yeung et al, 2002;Kamendi et al, 2015), human (Weiss and Manthel, 1977;Chlebowski et al, 1980;Legha et al, 1982a;Torti et al, 1983) Dose (Forssen and Tökès, 1981;Kanter et al, 1993b), beagle dog (Herman et al, 1983;Kanter et al, 1993a;Working et al, 1999), rabbit (Working et al, 1999), human (Berry et al, 1998;Lotem et al, 2000;Lyass et al, 2000;Safra et al, 2000;O'Brien et al, 2004) Stomatitis is another major toxic effect observed (Lyu et al, 2007;Deng et al, 2014), mouse…”