Doxorubicin Cardiotoxicity: Pathophysiology Updates

Hoeger, Christopher W.; Turissini, Cole; Asnani, Aarti

doi:10.1007/s11936-020-00842-w

Cited by 11 publications

(8 citation statements)

References 90 publications

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“…Although the precise mechanism underlying DOX-induced cardiotoxicity is not fully elucidated, multiple studies have suggested that oxidative stress, lipid peroxidation, inflammation in cardiac tissues, and apoptosis contribute significantly to the development of DOX-induced cardiomyopathy. 29,30 Dexrazoxane, the only FDA-approved medication for preventing DOX cardiotoxicity, is associated with numerous side effects and can potentially reduce the anti-neoplastic activity of DOX. 13 Therefore, there is still a drastic need for the development of preventive strategies for this cardiotoxicity.…”

Section: Discussionmentioning

confidence: 99%

The protective effects of topiramate and spirulina against doxorubicin-induced cardiotoxicity in rats

Elmorsi,

El Saadany,

Kabel

et al. 2023

Hum Exp Toxicol

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Doxorubicin (DOX) is a widely used chemotherapy drug that can cause significant cardiotoxicity, limiting its clinical application. This study aimed to investigate the potential protective effects of topiramate (TPM) and spirulina (SP), either alone or in combination, in preventing DOX-induced cardiotoxicity. Adult Sprague Dawley rats were divided into five groups, including a normal control group and groups receiving DOX alone, DOX with TPM, DOX with SP, or DOX with a combination of TPM and SP. Cardiotoxicity was induced by administering DOX intraperitoneally at a cumulative dose of 16 mg/kg over 4 weeks. TPM and/or SP administration started 1 week before DOX treatment and continued for 35 days. Body weight, serum markers of cardiac damage, oxidative stress and inflammatory parameters were assessed. Histopathological and immunohistochemical examinations were performed on cardiac tissues. Results showed that TPM and SP monotherapy led to significant improvements in serum levels of cardiac markers, decreased oxidative stress, reduced fibrosis-related growth factor levels, increased antioxidant levels, and improved histopathological features. SP demonstrated more prominent effects in comparison to TPM, and the combination of TPM and SP exhibited even more pronounced effects. In conclusion, TPM and SP, either alone or in combination, hold promise as therapeutic interventions for mitigating DOX-induced cardiotoxicity.

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Section: Discussionmentioning

confidence: 99%

The protective effects of topiramate and spirulina against doxorubicin-induced cardiotoxicity in rats

Elmorsi,

El Saadany,

Kabel

et al. 2023

Hum Exp Toxicol

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“…Mitoxantrone (MTO) is a novel anthracycline anticancer drug with a structure similar to that of doxorubicin, but it has lower cardiac toxicity because it does not generate free radicals in the body. 141 Zeng et al 142 prepared a polymeric prodrug PMTO by the copolymerization of MTO with 3,3′dithiodipropionic acid and methoxy polyethylene glycol (mPEG). Upon laser irradiation, PMTO exhibited a mild photothermal effect, which enhanced the cellular uptake and selective tumor accumulation by increasing the permeability of cell membrane and vascular.…”

Section: Self-immolative Polymeric Prodrugsmentioning

confidence: 99%

Section: Sip-based Drug Delivery Systemmentioning

confidence: 99%

Recent Advances in Stimuli-Responsive Self-Immolative Polymers for Drug Delivery and Molecular Imaging

Li,

Liu,

et al. 2024

Chem. Mater.

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Stimuli-responsive self-immolative polymers (SIPs) represent a unique class of polymers that can undergo controlled, sequential head-to-tail depolymerization upon specific stimuli. Since their inception, they have evolved over two decades to become one of the most attractive polymer types. With their characteristic feature of "one stimulus, multiple responses", SIPs inherently possess the ability to serve as chemical amplifiers, which can amplify weak chemical or biological signals. This feature promises higher stimulus sensitivity, greater selectivity for specific microenvironments, and the potential to generate more persistent, extensive, and significant responses while consuming fewer stimuli sources. This Review summarizes the latest research advancements in stimuli-responsive SIPs for drug delivery and molecular imaging over the past five years. Regarding the structure of SIPs, we briefly overview the updates in self-immolation units, end-cap moieties, and sequence of SIPs. In terms of applications, we focus on the possible biological applications of SIPs in drug delivery for disease treatment and potential imaging methods. Finally, we provide a brief perspective of potential future directions for SIPs in these applications.

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“…However, its dose-dependent cardiotoxic effects have limited its use. Studies have shown a significant reduction in ErbB4 expression after DOX treatment [56]. Neuregulin-1-ErbB signaling is an essential pathway for normal cardiac function in adults.…”

Section: Cardiomyopathymentioning

confidence: 99%

MicroRNA-146: Biomarker and Mediator of Cardiovascular Disease

et al. 2022

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Cardiovascular diseases (CVDs) are the prime cause of morbidity and mortality worldwide. Although noticeable progress has been made in the diagnosis, prognosis, and treatment, there is still a critical demand for new diagnostic biomarkers and novel therapeutic interventions to reduce this disease incidence. Many investigations have been conducted on the regulatory effects of microRNAs in cardiovascular diseases. miRNA circulating serum level changes are correlated with several CVDs. In addition, there is growing evidence representing the potential role of miRNAs as diagnostic biomarkers or potential therapeutic targets for CVD. Preliminary studies identified the prominent role of miR-146 in host defense, innate immunity, and different immunological diseases by regulating cytokine production and innate immunity modification in bacterial infections. However, more recently, it was also associated with CVD development. miR-146 has received much attention, with positive results in most studies. Research demonstrated the crucial role of this molecule in the pathogenesis of cardiac disease and related mechanisms. As a result, many potential applications of miR-146 are expected. In this paper, we provide an overview of recent studies highlighting the role of miR-146 in CVD, focusing on CAD (coronary artery disease), cardiomyopathy, and MI (myocardial infarction) in particular and discussing its current scientific state, and use a prognostic biomarker as a therapeutic agent for cardiovascular diseases.

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Doxorubicin Cardiotoxicity: Pathophysiology Updates

Cited by 11 publications

References 90 publications

The protective effects of topiramate and spirulina against doxorubicin-induced cardiotoxicity in rats

The protective effects of topiramate and spirulina against doxorubicin-induced cardiotoxicity in rats

Recent Advances in Stimuli-Responsive Self-Immolative Polymers for Drug Delivery and Molecular Imaging

MicroRNA-146: Biomarker and Mediator of Cardiovascular Disease

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