2022
DOI: 10.1016/j.ijscr.2022.106895
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Doxorubicin and ifosfamide for recurrent renal synovial sarcoma: The first case report in Indonesia

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Cited by 4 publications
(3 citation statements)
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References 17 publications
(23 reference statements)
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“…Immunopositivity for vimentin, CD99, and BCL2 of the spindle cells and that of cyst epithelium for cytokeratins could be very useful [28,29] although biphasic variant is often negative to cytokeratins [1]. Moreover cytogenetics and molecular studies (FISH or RT-PCR) can reveal the translocation of t(X;18)(p11.2;q11.2) that is the fusion of SYT genechromosome 18-with SSX genes (1, 2 or 4)-chromosome X (SYT-SSX gene fusion protein, SS18-SSX2 is the most frequent), that are found in 90% of SS cases [1,20,[29][30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…Immunopositivity for vimentin, CD99, and BCL2 of the spindle cells and that of cyst epithelium for cytokeratins could be very useful [28,29] although biphasic variant is often negative to cytokeratins [1]. Moreover cytogenetics and molecular studies (FISH or RT-PCR) can reveal the translocation of t(X;18)(p11.2;q11.2) that is the fusion of SYT genechromosome 18-with SSX genes (1, 2 or 4)-chromosome X (SYT-SSX gene fusion protein, SS18-SSX2 is the most frequent), that are found in 90% of SS cases [1,20,[29][30][31][32][33].…”
Section: Discussionmentioning
confidence: 99%
“…The best treatment for synovial sarcoma is radical resection with negative margins combined with sequential radiotherapy and chemotherapy after the surgery. 13 Radiotherapy is considered an effective adjuvant therapy for synovial sarcoma that can reduce the local recurrence and prolong the survival period of patients, but it can also improve the quality of the patient's life. Chemotherapy has no evident effects on synovial sarcoma compared with radiotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…High-dose ifosfamide with or without doxorubicin is recommended for failed cases. Adjuvant chemotherapy and radiotherapy should be considered for all patients [ 3 , 5 ].…”
Section: Introductionmentioning
confidence: 99%