Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema

Groene, D.; Martus, Peter; Heyer, G.

doi:10.1034/j.1600-0625.2001.010002110.x

Cited by 27 publications

(12 citation statements)

References 44 publications

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“…According to our data, we claim that the antipruritic effect of analgesic drugs might have been less likely arised from the phenomena of allokinesis or hyperkinesis because of the evaluating the acute situations. It is well known that both allokinesis and hyperkinesis are the phenomena seen in the chronic processes, such as atopic dermatitis (Heyer et al 1995, Groene et al 2001. For instance in the study performed by Groene and others (2001), intradermally injected of acetylcholine, which normally provokes pain, provokes itch in patients with atopic dermatitis.…”

Section: Discussionmentioning

confidence: 99%

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

İlkaya¹,

Yeşilyurt²,

Seyrek³

et al. 2016

Acta Neurobiologiae Experimentalis

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Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation. In this study, we explored the effects of different group of analgesic drugs on serotonin and compound 48/80-induced scratching behavior in Balb-C mice. Serotonin (25 μg) and compound 48/80 (100 μg) was injected intradermally in a volume of 50 μl into the rostral part of skin on the back of male mice and scratches were counted for a 30-min observation period. Morphine (1, 3, 10 mg/kg), tramadol (20, 40, 80 mg/kg), cannabinoid agonist CP 55,940 (0.1, 0.3, 1 mg/kg), paracetamol (100, 200, 300 mg/kg) and diclofenac (50, 100, 200 mg/kg) were given intraperitoneally 30 min prior to pruritogen injection. The analgesic drugs dose dependently blocked serotonin and compound 48/80-induced straching behavior with exerting complete inhibition at certain doses. Our data suggests that intradermal pruritogen-induced scratching models may not discriminate pain and itch sensations and give false positive results when standard analgesic drugs are used.

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Section: Discussionmentioning

confidence: 99%

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

İlkaya¹,

Yeşilyurt²,

Seyrek³

et al. 2016

Acta Neurobiologiae Experimentalis

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“…It was observed that doxepin didn't have a greater antipruritic effect when compared with placebo, and the author referred it should be due to the moisturizing effect of the base solution used as a placebo, although the dimension of the papule was lower in the forearm that received doxepin, suggesting that acetylcholine caused less reaction. 22 …”

Section: Resultsmentioning

confidence: 99%

Psychotropics in different causes of itch: systematic review with controlled studies

Brasileiro

Barreto

Nunes

2016

An. Bras. Dermatol.

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Among the wide range of symptoms neglected or resistant to conventional treatments in clinical practice, itch is emerging gradually as a theme to be studied. Itch complaints and the negative effects in the quality of life are observed in several medical fields. Although the partially obscure pathophysiology, some researchers decided to check and test the use of psychotropic drugs in resistant itch to conventional topical treatments and antihistamines. The objective of this study was to evaluate scientific evidence in psychotropic use in the treatment of itch of various causes. This is a systematic review of scientific literature. The following databases were used: PubMed, Web of Science, Scopus and Scielo. Randomized controlled trials that should focus on treatment with psychotropic drugs of pruritus of various causes were the inclusion criteria. All articles were analyzed by the authors, and the consensus was reached in cases of disagreement. Fifteen articles were included after analysis and selection in databases, with the majority of clinical trials focusing on psychopharmacological treatment of itch on account of chronic kidney disease. Clinical trials with psychotropic drugs mostly indicated significant improvement in the itching. In most trials of chronic kidney disease as basal disease for itch, greater effectiveness was observed with the use of psychotropic drugs compared with placebo or other antipruritic. However, the small amount of controlled trials conducted precludes the generalization that psychiatric drugs are effective for itch of various causes.

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“…Nebenwirkungen wurden insbesondere bei mit Doxepin-Creme behandelten Patienten angegeben, die bei 17 Patienten zum Abbruch der Therapie führten. Die starken antipruriginösen Effekte der topischen Doxepin-Behandlung konnten in einer kleineren doppelblinden Studie an 11 Patienten mit atopischer Dermatitis nicht bestätigt werden, bei der der antipruritische Effekt nach Aectylcholin-Injektion der der Basistherapie entsprach [8].…”

Section: » Aufgrund Der Starkenunclassified

Psychopharmakatherapie bei Pruritus

Raap

Kapp

Darsow³

2012

Hautarzt

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Pruritus represents one of the most bothersome symptoms of skin and internal diseases, and can also occur without an underlying detectable cause. It is well known that chronic pruritus seriously affects the quality of life in patients. The management of pruritus is challenging, especially if the underlying cause is not identifiable. Besides therapy with increased dosage of non-sedating H1-antihistamines, which is often not successful in severe pruritus, tri- or tetracyclic antidepressants and selective serotonin-reuptake inhibitors are recommended for therapy, as discussed in this review.

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Doxepin affects acetylcholine induced cutaneous reactions in atopic eczema

Cited by 27 publications

References 44 publications

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

Psychotropics in different causes of itch: systematic review with controlled studies

Psychopharmakatherapie bei Pruritus

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