Downstream process development of biobutanol using deep eutectic solvent

Kim, Byoung Chul; Park, Jin Whan; Kim, Young Han

doi:10.1007/s11814-022-1265-2

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…Microfluidic chip facilitates the provision of tissue-mimetic physiological environments and stimulation for organoids, such as vascular network, ALI, mechanical strain, and fluid flow ( Figure 4 ). 96 – 99 Lung organoid culture system adopting microfluidics facilitates the seamless integration of continuous perfusion with culture media, drugs, or various factors, thereby effectively replicating fluid-induced shear stresses and emulating the physiological functions of the lungs in vivo. 89 , 100 , 105 Because of these characteristics, microfluidic system offers advantages in replicating the alveolar-capillary interface, biomechanical activity, and inherent biological functions of the lungs.…”

Section: Advanced Organoid Culture Platformsmentioning

confidence: 99%

Advanced lung organoids for respiratory system and pulmonary disease modeling

Joo,

Min,

Cho

2024

J Tissue Eng

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Amidst the recent coronavirus disease 2019 (COVID-19) pandemic, respiratory system research has made remarkable progress, particularly focusing on infectious diseases. Lung organoid, a miniaturized structure recapitulating lung tissue, has gained global attention because of its advantages over other conventional models such as two-dimensional (2D) cell models and animal models. Nevertheless, lung organoids still face limitations concerning heterogeneity, complexity, and maturity compared to the native lung tissue. To address these limitations, researchers have employed co-culture methods with various cell types including endothelial cells, mesenchymal cells, and immune cells, and incorporated bioengineering platforms such as air-liquid interfaces, microfluidic chips, and functional hydrogels. These advancements have facilitated applications of lung organoids to studies of pulmonary diseases, providing insights into disease mechanisms and potential treatments. This review introduces recent progress in the production methods of lung organoids, strategies for improving maturity, functionality, and complexity of organoids, and their application in disease modeling, including respiratory infection and pulmonary fibrosis.

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Section: Advanced Organoid Culture Platformsmentioning

confidence: 99%

Advanced lung organoids for respiratory system and pulmonary disease modeling

Joo,

Min,

Cho

2024

J Tissue Eng

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“…to solve forward and inverse problems arising from steadystate flows of power-law fluids in various geometries, 19,20) and model channel flows of fluids with different rheological constitutive models under varying flow protocols. 21) In this paper, we present a simulation of a pulsatile shearthinning channel flow using PINNs.…”

Section: Introductionmentioning

confidence: 99%

Optimizing a Physics-Informed Machine Learning Model for Pulsatile Shear-Thinning Channel Flow

Son,

Park,

Kwak

et al. 2024

J. Soc. Rheol., Jpn

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This paper explores the application of physics-informed neural networks for solving pulsatile shear-thinning flows in a two-dimensional channel. To identify an optimal model, models of varying implementations of boundary conditions, network sizes, number of training points, activation functions, and loss weights are investigated through case by case studies complemented by Gaussian-processes based Bayesian optimization. The final model demonstrates a high level of agreement with a reference numerical solution, with an error of less than 2%. This result indicates that appropriately trained PINNs can be utilized as a method for simulating transient shear-thinning flows.

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