Downstream extraction process development for recovery of organic acids from a fermentation broth

Bekatorou, Argyro; Dima, Agapi; Tsafrakidou, Panagiota; Boura, Konstantina; Lappa, Katerina; Kandylis, Panagiotis; Pissaridi, Katerina; Κουτίνας, Αθανάσιος Α.

doi:10.1016/j.biortech.2016.08.039

Cited by 37 publications

(19 citation statements)

References 17 publications

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“…One of the big challenges with VFA production via AF is product separation and recovery. The recovery of organic acids is typically 30-40% of the processing cost (Bekatorou et al, 2016), therefore economically viable recovery processes need to be developed. It is desirable to integrate the primary separation step with the fermentation, through in situ product recovery (ISPR) (Zhou et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Solvent-free membrane extraction of volatile fatty acids from acidogenic fermentation

Outram

Zhang

2018

Bioresource Technology

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Diversification of anaerobic digestion into higher value products, namely volatile fatty acids (VFAs), is receiving interest. One of the biggest challenges with this is recovery of the VFAs. Membrane extraction can be used, and a novel process configuration using a non-porous silicone membrane and water for an extractant is proposed here. This process would enable the reduction in the number of downstream unit operations compared to other membrane extraction processes. Selective recovery in favour of longer chain VFAs was demonstrated. Testing with a synthetic solution resulted in an overall mass transfer coefficient of 0.088 μm s for butyric acid, and 0.157 μm s when fermentation broth was used. This indicates this process is not hindered by fouling, but improved somehow. Although the preliminary economic analysis showed this process to require a larger membrane area compared to porous membrane alternatives, it also has a significantly reduced cost associated with the extractant.

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Section: Introductionmentioning

confidence: 99%

Solvent-free membrane extraction of volatile fatty acids from acidogenic fermentation

Outram

Zhang

2018

Bioresource Technology

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“…However, the resulting fermentation broth (FB) was characterized by low product concentrations and a heterogenic composition with, e.g., substrate particles and microorganisms besides dissolved compounds. This makes the development of an effective and efficient recovery process of fermentation-based organic acids particularly challenging ( Hong and Hong, 2005 ; López-Garzón and Straathof, 2014 ; Bekatorou et al, 2016 ; Li et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

A Downstream Processing Cascade for Separation of Caproic and Caprylic Acid from Maize Silage-Based Fermentation Broth

Braune

Yuan

Sträuber

et al. 2021

Front. Bioeng. Biotechnol.

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Production of caproic and caprylic acid through anaerobic fermentation of crops or residual and waste biomass has been regarded as an alternative to the conventional ways, where plant oils and animal fats are mostly used. The downstream processing of the fermentation broth is a particular challenge since the broth has a highly complex composition and low concentrations of the target products. In this study, the proof-of-principle for a separation cascade for caproic (C6) and caprylic acid (C8) produced in a maize silage-based fermentation process was demonstrated. For clarification of the fermentation broth, a filter press and a ceramic ultrafiltration membrane was used to remove coarse solids and to separate suspended particles and macromolecules from the fermentation broth, respectively. With both techniques, the dry matter content was reduced from 6.8 to 2.3% and a particle-free product solution was obtained. Subsequently, the carboxylic acids were extracted with oleyl alcohol by liquid-liquid extraction with an extraction efficiency of 85% for C6 and 97% for C8. Over the whole cascade, 58% of caproic acid and 66% of caprylic acid were recovered from the fermentation broth into the extract. Among all separation steps, solid-liquid separation with the filter press caused the major part of the product loss of 21% of each carboxylic acid. By using separation equipment with a better solid separation efficiency such as decanter centrifuges or belt filter presses this loss could be minimized.

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“…In this context, the processes of isolation and purification of organic acids become critical [78,79]. Various alternatives for the isolation and purification of organic acids from fermentation broth or biomass have been used.…”

Section: Organic Acid Market: Overview and Perspectivesmentioning

confidence: 99%

Bioconversion of Lactose from Cheese Whey to Organic Acids

Pais-Chanfrau¹,

Núñez-Pérez²,

Espín-Valladares³

et al. 2020

Lactose and Lactose Derivatives

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Organic acids constitute a group of organic compounds that find multiple applications in the food, cosmetic, pharmaceutical, and chemical industries. For this reason, the market for these products is continuously growing. Traditionally, most organic acids have been produced by chemical synthesis from oil derivatives. However, the irreversible depletion of oil has led us to pay attention to other primary sources as possible raw materials to produce organic acids. The microbial production of organic acids from lactose could be a valid, economical, and sustainable alternative to guarantee the sustained demand for organic acids. Considering that lactose is a by-product of the dairy industry, this review describes different procedures to obtain organic acids from lactose by using microbial bioprocesses.

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Downstream extraction process development for recovery of organic acids from a fermentation broth

Cited by 37 publications

References 17 publications

Solvent-free membrane extraction of volatile fatty acids from acidogenic fermentation

Solvent-free membrane extraction of volatile fatty acids from acidogenic fermentation

A Downstream Processing Cascade for Separation of Caproic and Caprylic Acid from Maize Silage-Based Fermentation Broth

Bioconversion of Lactose from Cheese Whey to Organic Acids

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