Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

Yang, Lu; Du, Chunfu; Chen, Hui; Diao, Zhengwen

doi:10.4081/ejh.2021.3255

Cited by 2 publications

(2 citation statements)

References 22 publications

(26 reference statements)

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“…Survival analysis suggested that overexpression of BAZ1B was associated with poor prognosis in most tumors, especially in KIRC, LGG, LUAD, and MESO. This is consistent with the conclusion that Meng, et al [9] in studying LUAD and Yang, et al [38] in studying GBM, which both conclude that BAZ1B as an oncoprotein accelerates the proliferation and invasion of cancer cells among cancer patients.…”

Section: The Williams Syndrome Transcription Factor (Wstf)supporting

confidence: 90%

Pan Cancer Insights into BAZ1B as a Prognostic and Immunological Marker

Xin¹,

Li²,

Zhang³

et al. 2022

J Biomed Res Environ Sci

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Background: The Bromodomain Adjacent to the Zinc Finger Domain 1B (BAZ1B) is a versatile nuclear protein. BAZ1B acts on chromatin remodeling, participates in DNA replication and damage repair, and is involved in RNA transcription based on its kinase activity. Although many experimental data support a close relationship between BAZ1B and cancer, its role in pan-cancer remains unclear. Our study aimed to analyze the prognostic and immune functions of BAZ1B expression in different cancers. Methods: Based on different databases, we investigated the potential carcinogenicity of BAZ1B, including the expression of all TCGA tumors, correlation with prognosis, Tumor Microenvironment (TME), protein phosphorylation, and functional enrichment. Results: The results showed that BAZ1B was overexpressed in a variety of cancers, and there was a significant correlation between gene mutations and poor prognosis associated with high expression in most cancer patients. We observed elevated phosphorylation levels in breast cancer and lung adenocarcinoma. A significant relationship was also found between BAZ1B expression and TME, including tumor-associated fibroblast infiltration. We also observed that the cellular function of DNA and hepatocellular carcinoma may be related to the molecular mechanism of BAZ1B. Conclusion: The prognostic and immunological markers of BAZ1B provides a new understanding for future studies in our first pan-cancer analysis.

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Section: The Williams Syndrome Transcription Factor (Wstf)supporting

confidence: 90%

Pan Cancer Insights into BAZ1B as a Prognostic and Immunological Marker

Xin¹,

Li²,

Zhang³

et al. 2022

J Biomed Res Environ Sci

View full text Add to dashboard Cite

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“…For instance, overexpression of NCAPG2 can regulate the activation of Wnt/β-catenin pathway to promote proliferation, migration, and invasion of GBM cells, and knockdown of NCAPG2 inhibited tumorigenesis of GBM in vivo ( 33 ). Also, the high expression of BAZ1B can also increase proliferation, migration, invasion, and inhibition of apoptosis in GBM cells ( 34 ). In our study, the NCAPG2 and BAZ1B genes were positively related to NUP205 and have been reported as oncogenes for glioma.…”

Section: Discussionmentioning

confidence: 99%

Exploring the relationship between abnormally high expression of NUP205 and the clinicopathological characteristics, immune microenvironment, and prognostic value of lower-grade glioma

Liang

Zhu

et al. 2023

Front. Oncol.

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Nuclear pore complex (NPC) is a major transport pivot for nucleocytoplasmic molecule exchange. Nucleoporin 205 (NUP205)—a main component of NPC—plays a key regulatory role in tumor cell proliferation; however, few reports document its effect on the pathological progression of lower-grade glioma (LGG). Therefore, we conducted an integrated analysis using 906 samples from multiple public databases to explore the effects of NUP205 on the prognosis, clinicopathological characteristics, regulatory mechanism, and tumor immune microenvironment (TIME) formation in LGG. First, multiple methods consistently showed that the mRNA and protein expression levels of NUP205 were higher in LGG tumor tissue than in normal brain tissue. This increased expression was mainly noted in the higher WHO Grade, IDH-wild type, and 1p19q non-codeleted type. Second, various survival analysis methods showed that the highly expressed NUP205 was an independent risk indicator that led to reduced survival time of patients with LGG. Third, GSEA analysis showed that NUP205 regulated the pathological progress of LGG via the cell cycle, notch signaling pathway, and aminoacyl-tRNA biosynthesis. Ultimately, immune correlation analysis suggested that high NUP205 expression was positively correlated with the infiltration of multiple immune cells, particularly M2 macrophages, and was positively correlated with eight immune checkpoints, particularly PD-L1. Collectively, this study documented the pathogenicity of NUP205 in LGG for the first time, expanding our understanding of its molecular function. Furthermore, this study highlighted the potential value of NUP205 as a target of anti-LGG immunotherapy.

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Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

Cited by 2 publications

References 22 publications

Pan Cancer Insights into BAZ1B as a Prognostic and Immunological Marker

Pan Cancer Insights into BAZ1B as a Prognostic and Immunological Marker

Exploring the relationship between abnormally high expression of NUP205 and the clinicopathological characteristics, immune microenvironment, and prognostic value of lower-grade glioma

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