Downregulation of the Gene Expression of Efflux Pump Gene (acrA) and its Regulator (ramA) in Klebsiella pneumoniae by Quaternary Ammonium Compounds
Farah Hadi Odaa
Abstract:Biocides are commonly used for disinfection in a variety of contexts. They are generally used to avoid infection by controlling biofilm on medical equipment. However, the literature lacks information on the effect of biocide on efflux pump gene expression.Objective: To determine the influence of biocide on biofilm development and efflux pump acrA and ramA gene expression.
Methodology:The microtiter plate method was used to identify biofilm development in 80 isolates of K. pneumoniae. The minimal inhibitory con… Show more
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