Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes

Sevilla-Domingo, Manuel; Olivo-Ramirez, Cynthia Giovanna; Huerta-Padilla, Víctor; Gómez-Díaz, Rita A.; Gonzalez-Carranza, Edith; Acevedo-Rodriguez, Gabriela Eridani; Hernandez-Zuñiga, Victor Eduardo; González, Adriana; Mateos-Sánchez, Leovigildo; Mondragón-González, Rafael; Garrido‐Magaña, Eulalia; Ramirez-Garcia, Luz A.; Wacher, Niels H; Vargas, Mauricio Salcedo

doi:10.1016/j.arcmed.2022.07.002

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Due to the significant long-term impacts of gestational diabetes on both the mother’s and offspring’s heath, many studies have started to devise predictive methodologies with which to identify those females most at risk [ 39 ]. Such studies have focused on identifying specific biomarkers, such as changes in DNA methylation of specific genes (e.g., SLC16A11 ) [ 40 ], tissue proteome and transcriptome profiling [ 41 ]; elucidating and characterizing the biochemical cargo of extracellular vesicles [ 42 ]; and establishing optimal dietary regimens [ 43 ]. Interestingly, studies have indicated that multiple micronutrient supplementation in women from high-income countries is associated with an increased risk of developing gestational diabetes and fetal overgrowth [ 44 , 45 ].…”

Section: Parental Diet and Obesitymentioning

confidence: 99%

Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development

et al. 2022

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As adults, our health can be influenced by a range of lifestyle and environmental factors, increasing the risk for developing a series of non-communicable diseases such as type 2 diabetes, heart disease and obesity. Over the past few decades, our understanding of how our adult health can be shaped by events occurring before birth has developed into a well-supported concept, the Developmental Origins of Health and Disease (DOHaD). Supported by epidemiological data and experimental studies, specific mechanisms have been defined linking environmental perturbations, disrupted fetal and neonatal development and adult ill-health. Originally, such studies focused on the significance of poor maternal health during pregnancy. However, the role of the father in directing the development and well-being of his offspring has come into recent focus. Whereas these studies identify the individual role of each parent in shaping the long-term health of their offspring, few studies have explored the combined influences of both parents on offspring well-being. Such understanding is necessary as parental influences on offspring development extend beyond the direct genetic contributions from the sperm and oocyte. This article reviews our current understanding of the parental contribution to offspring health, exploring some of the mechanisms linking parental well-being with gamete quality, embryo development and offspring health.

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Section: Parental Diet and Obesitymentioning

confidence: 99%

Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development

et al. 2022

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“…SLC16A11, a protein in the endoplasmic reticulum and plasma membrane, is involved in pyruvate transport and lipid metabolism. Its abnormal expression or mutation is associated with various metabolic diseases such as type 2 diabetes, fatty liver, and obesity, all of which are risk factors for aging and cancer ( 42 , 43 ). Therefore, the SLC16A11 gene may be an important target for regulating cellular senescence, immune cell exhaustion, and tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC

Shi

Liu

et al. 2023

Front. Immunol.

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ObjectivesThe exhausted CD8+T (Tex) cells are a unique cell population of activated T cells that emerges in response to persistent viral infection or tumor antigens. Tex cells showed the characteristics of aging cells, including weakened self-renewal ability, effector function inhibition, sustained high expression of inhibitory receptors including PD-1, TIGIT, TIM-3, and LAG-3, and always accompanied by metabolic and epigenetic reprogramming. Tex cells are getting more and more attention in researching immune-related diseases and tumor immunotherapy. However, studies on Tex-related models for tumor prognosis are still lacking. We hope to establish a risk model based on Tex-related genes for HCC prognosis.MethodsTex-related GEO datasets from different pathologic factors (chronic HBV, chronic HCV, and telomere shortening) were analyzed respectively to acquire differentially expressed genes (DEGs) by the ‘limma’ package of R. Genes with at least one intersection were incorporated into Tex-related gene set. GO, KEGG, and GSEA enrichment analyses were produced. Hub genes and the PPI network were established and visualized by the STRING website and Cytoscape software. Transcription factors and targeting small molecules were predicted by the TRUST and CLUE websites. The Tex-related HCC prognostic model was built by Cox regression and verified based on different datasets. Tumor immune dysfunction and exclusion (TIDE) and SubMap algorithms tested immunotherapy sensitivity. Finally, qRT-PCR and Flow Cytometry was used to confirm the bioinformatic results.ResultsHub genes such as AKT1, CDC6, TNF and their upstream transcription factor ILF3, Regulatory factor X-associated protein, STAT3, JUN, and RELA/NFKB1 were identified as potential motivators for Tex. Tex-related genes SLC16A11, CACYBP, HSF2, and ATG10 built the HCC prognostic model and helped with Immunotherapy sensitivity prediction.ConclusionOur study demonstrated that Tex-related genes might provide accurate prediction for HCC patients in clinical decision-making, prognostic assessment, and immunotherapy. In addition, targeting the hub genes or transcription factors may help to reverse T cell function and enhance the effect of tumor immunotherapy.

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Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes

Cited by 2 publications

References 19 publications

Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development

Parental Programming of Offspring Health: The Intricate Interplay between Diet, Environment, Reproduction and Development

Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC

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