Downregulation of Semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
Miki Kume,
Hanako Koguchi-Yoshioka,
Shuichi Nakai
et al.
Abstract:Psoriasis is a multifactorial disorder mediated by IL-17-producing T cells, involving immune cells and skin-constituting cells. Semaphorin 4A (Sema4A), an immune semaphorin, is known to take part in T helper type 1/17 differentiation and activation. However, Sema4A is also crucial for maintaining peripheral tissue homeostasis and its involvement in skin remains unknown. Here, we revealed that while Sema4A expression was pronounced in psoriatic blood lymphocytes and monocytes, it was downregulated in the kerati… Show more
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