Downregulation of Selected Cytokines in Amebiasis

Bekker-Méndez, Vilma Carolina; Pérez-Castillo, Viola Leticia; Rico-Rosillo, María Guadalupe; Pérez-Rodríguez, Martha; Arellano-Blanco, J; Kretschmer-Schmid, Roberto Rodolfo; Talamás-Rohana, Patricia

doi:10.1016/j.arcmed.2005.09.018

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Additionally, IL‐5, IFN‐γ and TNF‐α levels were also lower in patients, but IL‐2, IL‐4 and IL‐10 levels were similar in both groups (58). Therefore, a downregulated IL‐6 cytokine production may enhance ALA development (59).…”

Section: Amoebic Liver Abscessmentioning

confidence: 99%

Regulation of the inflammatory immune response by the cytokine/chemokine network in amoebiasis

García‐Zepeda

Rojas-López

Esquivel-Velázquez

et al. 2007

Parasite Immunology

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Amoebiasis is caused by the protozoa Entamoeba histolytica and persists as one of the leading parasitic diseases affecting millions worldwide. This parasite invades the intestinal mucosa, causing amoebic colitis and ulcers. It may also spread to other organs, mainly the liver, causing amoebic liver abscess (ALA). Current research efforts have focused on the development of specific diagnostic tests and animal models searching for a better understanding of the complex physiopathology of this disease. Analysis of the inflammatory immune response during intestinal amoebiasis in both human disease and animal murine models has revealed an important regulatory role for chemokines and cytokines. Recruitment and activation of inflammatory cells can also be modulated by specific protease-mediated cleavage of cytokines and by secreted amoebic factors such as amoebapores and monocyte locomotion inhibitory factor (MLIF). Unlike intestinal amoebiasis, analysis of the immune response in ALA has mainly been done in the hamster model. This has limited our information regarding the immune response during this phase of the disease. However, even with these limitations, several Th1/2 cytokines, such as IL-6 and IL-4, and regulatory cytokines, like IL-10 and TGFbeta, have been associated to the development of this disease.

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Section: Amoebic Liver Abscessmentioning

confidence: 99%

Regulation of the inflammatory immune response by the cytokine/chemokine network in amoebiasis

García‐Zepeda

Rojas-López

Esquivel-Velázquez

et al. 2007

Parasite Immunology

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“…Además, los niveles de IL-5, IFN-γ y TNF-α también fueron más bajos en los pacientes, pero los niveles de IL-2, IL-4 e IL-10 fueron similares en ambos grupos (49). Por lo tanto, una producción de citoquina IL-6 regulada negativamente puede potenciar el desarrollo de AHA (50). Por otra parte, se ha observado el papel supresor de la IL-10 en la amebiasis, al estudiar células mononucleares periféricas aisladas de sujetos sintomáticos que expresaban altos niveles de IL-10 (51).…”

Section: El Estudio De Las Citoquinas Como Ejemplo De Investigaciónunclassified

Las citoquinas en el absceso hepático amebiano: un ejemplo de investigación inmunología en el ámbito clínico

Baquero

2019

nova

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El propósito de esta revisión es resaltar la importancia de la investigación en el área de la inmunología y su aplicación en el ámbito clínico. En una primera parte se presentan los descubrimientos más importantes que ayudaron a dilucidar los principales procesos fisiológicos involucrados en las enfermedades y de esta manera ayudaron a redireccionar la investigación en el área de la inmunología. Seguido, se describe un ejemplo de investigación básica relacionada con el papel de las citocinas en el absceso hepático amebiano, mostrando el trabajo de varios grupos de investigación en el mundo, con el objetivo de entender la respuesta inmune contra el parásito. Lo anterior nos permite argumentar la relevancia que tiene la investigación inmunológica dentro del contexto clínico.

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Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica

Pacheco‐Yépez¹,

Martínez-Castillo

Cruz³

et al. 2017

Liver Pathophysiology

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Downregulation of Selected Cytokines in Amebiasis

Cited by 7 publications

References 20 publications

Regulation of the inflammatory immune response by the cytokine/chemokine network in amoebiasis

Regulation of the inflammatory immune response by the cytokine/chemokine network in amoebiasis

Las citoquinas en el absceso hepático amebiano: un ejemplo de investigación inmunología en el ámbito clínico

Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica

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