Downregulation of RUNX3 has a poor prognosis and promotes tumor progress in kidney cancer

Zheng, Jianbo; Mei, Yanhui; Zhai, Guangsheng; Zhao, Ning; Jia, Dongsheng; Fan, Yi‐Ming

doi:10.1016/j.urolonc.2020.05.021

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…In addition, RUNX3 has been shown to destabilize the oncogenic protein MYC, thereby exerting a suppressive effect on gastrointestinal and lung cancers [ 83 ]. Zheng et al demonstrated that RUNX3 expression is significantly down-regulated in renal cancer tissues, and that the loss of RUNX3 function in renal cancer tissues promotes the proliferation, migration, and invasion of renal cancer cells [ 84 ]. Complementing these findings, additional research has verified that RUNX3 expression is notably suppressed in metastatic renal cancer tissues due to hypermethylation of CpG islands [ 85 ].…”

Section: Runx Proteins In the Landscape Of Cancer Expressionmentioning

confidence: 99%

“…In NSCLC, Yu et al tested clinical samples and found that methylation of the RUNX3 promoter led to its reduced or absent expression, suggesting a poor prognosis [ 117 ]. The down-regulation of RUNX3 expression and its loss of function in renal cancer tissues are closely related to a poor prognosis of patients with renal cancer [ 84 ]. Cai et al demonstrated that RUNX3 expression is down-regulated in gallbladder cancer due to DNMT1-mediated promoter hypermethylation, and its downregulation is associated with a poor prognosis of patients with gallbladder cancer [ 89 ].…”

Section: Prognostic Implications Of Runx Proteinsmentioning

confidence: 99%

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RUNX transcription factors: biological functions and implications in cancer

Chen,

Wang,

Yang

et al. 2024

Clin Exp Med

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Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in malignancy is to promote the occurrence and development of acute myeloid leukemia. However, it is worth noting that during the last decade, studies of RUNX proteins in solid tumors have made considerable progress, suggesting that these proteins are directly involved in different stages of tumor development, including tumor initiation, progression, and invasion. RUNX proteins also play a role in tumor angiogenesis, the maintenance of tumor cell stemness, and resistance to antitumor drugs. These findings have led to the consideration of RUNX as a tumor biomarker. All RUNX proteins are involved in the occurrence and development of solid tumors, but the role of each RUNX protein in different tumors and the major signaling pathways involved are complicated by tumor heterogeneity and the interacting tumor microenvironment. Understanding how the dysregulation of RUNX in tumors affects normal biological processes is important to elucidate the molecular mechanisms by which RUNX affects malignant tumors.

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Section: Runx Proteins In the Landscape Of Cancer Expressionmentioning

confidence: 99%

Section: Prognostic Implications Of Runx Proteinsmentioning

confidence: 99%

RUNX transcription factors: biological functions and implications in cancer

Chen,

Wang,

Yang

et al. 2024

Clin Exp Med

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“…RUNX3 has been reported as a tumor suppressor in an increasing number of studies [ 8 , 9 , 33 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. Loss of the chromosomal region (1p36), where RUNX3 is located, is frequently found in various cancers, such as breast, liver, lung, bowel, nerve, and pancreatic cancers [ 93 ].…”

Section: Contributions Of Runx Proteins To Carcinogenesismentioning

confidence: 99%

RUNX Proteins as Epigenetic Modulators in Cancer

Zhu

et al. 2022

Cells

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RUNX proteins are highly conserved in metazoans and perform critical functions during development. Dysregulation of RUNX proteins through various molecular mechanisms facilitates the development and progression of various cancers, where different RUNX proteins show tumor type-specific functions and regulate different aspects of tumorigenesis by cross-talking with different signaling pathways such as Wnt, TGF-β, and Hippo. Molecularly, they could serve as transcription factors (TFs) to activate their direct target genes or interact with many other TFs to modulate chromatin architecture globally. Here, we review the current knowledge on the functions and regulations of RUNX proteins in different cancer types and highlight their potential role as epigenetic modulators in cancer.

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