Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma

Nguyen, Tung; Kuo, Calvin; Nicholl, Michael B.; Sim, Myung‐Shin; Turner, Roderick R.; Morton, Donald L.; Hoon, Dave S.B.

doi:10.4161/epi.6.3.14056

Cited by 185 publications

(154 citation statements)

References 31 publications

(43 reference statements)

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“…MiR-29c expression was inversely correlated to DNMT3A and 3B expression. These studies demonstrated that the miR-29c is a potential clinicopathological biomarker for differentiating between individual melanoma stages and its down-regulation may be indicative of aggressive disease 76 .…”

mentioning

confidence: 99%

The role of miR-29 family members in malignant hematopoiesis

Kollinerová¹,

Vassanelli²,

Modrianský³

2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims. MicroRNAs of the miR-29 family members were one of the first microRNAs identified as possible therapeutic agents in malignant hematopoiesis. The aim of our review is to summarize the current state of knowledge on miR-29 family members. Methods. We performed literature searches involving miR-29 family members and their relationship to individual hematological malignancies, namely acute myeloid leukemia (AML), chronic lymphoblastic leukemia (CLL) and chronic myeloid leukemia (CML). We also searched for subgroups of hematological malignancies, e.g. multiple myeloma, that are regarded as members of the acute or chronic types of leukemias. Results. A number of genes appear to be regulated by miR-29 family members in various physiological and pathological situations. In our view regulation of Tcl-1, Mcl-1 and DNA methyltransferases is relevant in case of hematological malignancies, hence these are the focus of this review. miR-29 family members also function during normal T-cell and B-cell development. Conclusion. MiR-29 family members appear to govern some general features in commonly heterogenous hematological malignancies and therefore form a potential target for treatment.

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mentioning

confidence: 99%

The role of miR-29 family members in malignant hematopoiesis

Kollinerová¹,

Vassanelli²,

Modrianský³

2014

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…In another study, Nguyen et al analyzed paraffin-embedded archival tissue and found miR-29c expression significantly downregulated in Stage IV melanoma compared to early-stage melanoma. Furthermore, in lymph nodes from Stage III melanoma patients, higher expression of miR-29c was found to be a significant predictor of improved overall survival (83). However, further data concerning miRNAs in patient samples are needed to better assess the potential of miRNAs as biomarkers in melanoma genesis and progression.…”

Section: Nonprotein Biomarkersmentioning

confidence: 99%

Biomarkers in Malignant Melanoma: Recent Trends and Critical Perspective

Belter

Haase-Kohn

Pietzsch

2017

Cutaneous Melanoma: Etiology and Therapy

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Abstract:The worldwide incidence of malignant melanoma is steadily increasing, suggesting a probable melanoma "epidemic." From a clinical point of view, malignant melanoma still is an unpredictable disease and, once in the advanced stage, allows only scarce therapeutic options. There is an urgent need to identify, characterize, and validate informative biomarkers, biomarker patterns, or surrogate markers in order to not only improve early diagnosis of melanoma but also for differential diagnosis, staging, prognosis, therapy selection, and therapy monitoring. In this chapter, an update on the ongoing debate on serologic and histologic markers such as lactate dehydrogenase, tyrosinase, S100 family of calcium-binding proteins, cyclooxygenase-2, matrix metalloproteinases, and stem and/or progenitor cell markers are presented, and novel, innovative, and promising trends currently being explored are discussed.

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“…Patients with LINE1-hypomethylation survive better than patients with LINE1-hypermethylation (28). Stage III melanoma patients display elevated levels of DNMT3a and DNMT3b, and this correlates with reduced overall survival (29). These changes impact expression of a host of genes (30).…”

Section: Dna Methylationmentioning

confidence: 99%

Epigenetic Cancer Prevention Mechanisms in Skin Cancer

Saha

Hornyak

Eckert

2013

AAPS J

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Abstract. Epigenetics is an important emerging area for study of mechanisms of cancer prevention. In recent years, it has been realized that cancer prevention agents, derived from natural dietary sources, impact cancer cell survival by modulating epigenetic processes. In the present manuscript, we review key epigenetic regulatory mechanisms and examine the impact of sulforaphane and green tea polyphenols on these processes. We also discuss available information on the epigenetics in the context of skin cancer. These studies indicate that diet-derived chemopreventive agents modulate DNA methylation status and histone modification via multiple processes and point to additional areas for study of epigenetic mechanisms in skin cancer.

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Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma

Cited by 185 publications

References 31 publications

The role of miR-29 family members in malignant hematopoiesis

The role of miR-29 family members in malignant hematopoiesis

Biomarkers in Malignant Melanoma: Recent Trends and Critical Perspective

Epigenetic Cancer Prevention Mechanisms in Skin Cancer

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