Downregulation of Linc‐RNA activator of myogenesis lncRNA participates in FGF2‐mediated proliferation of human periodontal ligament stem cells

Wu, Xiayi; Cao, Zeyuan; Chen, Huan; Ou, Qianmin; Huang, Xiaojun; Wang, Yan

doi:10.1002/jper.19-0317

Cited by 11 publications

(7 citation statements)

References 15 publications

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“…Table 3 presents 18 studies that investigated the role of lncRNAs in regulating cellular processes in PDL cells in the presence or absence of stimuli, including studies that compared H-PDL and P-PDL cells [ 60 , 61 , 62 , 63 , 64 , 65 ]. These studies also explored the role of lncRNAs in lipopolysaccharide (LPS)-induced inflammation [ 66 , 67 , 68 , 69 , 70 , 71 ], tumor necrosis factor-alpha (TNF-α)-induced inflammation [ 72 ], mechanical stress [ 73 , 74 , 75 ], hypoxia [ 76 ], and oxidative stress [ 77 ].…”

Section: Resultsmentioning

confidence: 99%

The Expression and Regulatory Roles of Long Non-Coding RNAs in Periodontal Ligament Cells: A Systematic Review

et al. 2022

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Periodontal ligament (PDL) cells play a pivotal role in periodontal and bone homeostasis and have promising potential for regenerative medicine and tissue engineering. There is compelling evidence that long non-coding RNAs (lncRNAs) are differentially expressed in PDL cells compared to other cell types and that these lncRNAs are involved in a variety of biological processes. This study systematically reviews the current evidence regarding the expression and regulatory functions of lncRNAs in PDL cells during various biological processes. A systematic search was conducted on PubMed, the Web of Science, Embase, and Google Scholar to include articles published up to 1 July 2021. Original research articles that investigated the expression or regulation of lncRNAs in PDL cells were selected and evaluated for a systematic review. Fifty studies were ultimately included, based on our eligibility criteria. Thirteen of these studies broadly explored the expression profiles of lncRNAs in PDL cells using microarray or RNA sequencing. Nineteen studies investigated the mechanisms by which lncRNAs regulate osteogenic differentiation in PDL cells. The remaining 18 studies investigated the mechanism by which lncRNAs regulate the responses of PDL cells to various stimuli, namely, lipopolysaccharide-induced inflammation, tumor necrosis factor alpha-induced inflammation, mechanical stress, oxidative stress, or hypoxia. We systematically reviewed studies on the expression and regulatory roles of lncRNAs in diverse biological processes in PDL cells, including osteogenic differentiation and cellular responses to inflammation, mechanical stress, and other stimuli. These results provide new insights that may guide the development of lncRNA-based therapeutics for periodontal and bone regeneration.

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Section: Resultsmentioning

confidence: 99%

The Expression and Regulatory Roles of Long Non-Coding RNAs in Periodontal Ligament Cells: A Systematic Review

et al. 2022

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“…A previous study has suggested the expression changes of more than 80 LncRNAs in P-PDLSCs compared to normal PDLSCs .72 Among them, the expression of LncRNA-TWIST1 is positively related to the osteogenic differentiation ability of P-PDLSCs ,75 and up-regulating LncRNA-PTCSC3 or down-regulating LncRNA-RAM both promote the proliferation of P-PDLSCs. 76,77 Another LncRNA, PDLSC osteogenesis impairmentrelated lncRNA (LncRNA-POIR), serves as a competitive endogenous molecule of miR-182 that can increase the expression of forkhead box O1, which then binds to β-catenin with TCF-4 to inhibit the canonic Wnt signaling pathway. Therefore, LncRNA-POIR down-regulation in P-PDLSCs impairs their osteogenic differentiation by indirectly activating the canonic Wnt signaling pathway .…”

Section: Retained Dysfunction Of Resident Pdlscs Under Epigenetic Reg...mentioning

confidence: 99%

Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms

Zhang

Deng

Tang

2021

Journal of Leukocyte Biology

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Periodontitis is characterized by the periodontium's pathologic destruction due to the host's overwhelmed inflammation to the dental plaque. The bacterial infections and subsequent host immune responses have shaped a distinct microenvironment, which generally affects resident periodontal ligament stem cells (PDLSCs). Interestingly, recent studies have revealed that impaired PDLSCs may also contribute to the disturbance of periodontal homeostasis. The putative vicious circle underlying the interesting “positive feedback” of PDLSCs in the periodontitis niche remains a hot research topic, whereas the inseparable interactions between resident PDLSCs and the periodontitis niche are still not fully understood. This review provides a microscopic view on the periodontitis progression, especially the quick but delicate immune responses to oral dysbacterial infections. We also summarize the interesting crosstalk of the resident PDLSCs with their surrounding periodontitis niche and potential mechanisms. Particularly, the microenvironment reduces the osteogenic properties of resident PDLSCs, which are closely related to their reparative activity. Reciprocally, these impaired PDLSCs may disrupt the microenvironment by aggravating the host immune responses, promoting aberrant angiogenesis, and facilitating the osteoclastic activity. We further recommend that more in‐depth studies are required to elucidate the interactions of PDLSCs with the periodontal microenvironment and provide novel interventions for periodontitis.

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“…Periodontitis is characterized by an imbalance between proliferation and apoptosis of periodontal ligament cells (PDLCs) 55 . Accumulating evidence has demonstrated that various lncRNAs exert vital roles in the proliferation and apoptosis of periodontitis PDLCs (pPDLCs) 17,56‐63 . Fibroblast growth factor‐2 (FGF2) is a pivotal promoter of PDLSCs proliferation 64 .…”

Section: The Role Of Lncrnas In the Pathophysiology Of Periodontitismentioning

confidence: 99%

“…MALAT1, a lncRNA overexpressed in periodontitis PDLSCs (pPDLSCs), was reported to promote periodontitis progression by upregulating the expression of fibroblast growth factor‐2 (FGF2) 56 . Conversely, the Linc‐RNA activator of myogenesis (Linc‐RAM), which was downregulated in pPDLSCs, attenuated the enhancing effect of FGF2 on the cell proliferation 60 . In addition, long non‐coding RNA domain containing 1‐antisense (lncRNA DCST1‐AS1), TUG1, and maternally expressed gene 3 (MEG3) were also downregulated in pPDLSCs 63,65,66 .…”

Section: The Role Of Lncrnas In the Pathophysiology Of Periodontitismentioning

confidence: 99%

Long non‐coding RNAs: Emerging roles in periodontitis

Yin

Lin

et al. 2021

J of Periodontal Research

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Periodontitis is a major burden of public health, affecting 20%–50% of the global population. It is a complex inflammatory disease characterized by the destruction of supporting structures of the teeth, leading to tooth loss and the emergence or worsening of systematic diseases. Understanding the molecular mechanisms underlying the physiopathology of periodontitis is beneficial for targeted therapeutics. Long non‐coding RNAs (lncRNAs), transcripts made up of more than 200 nucleotides, have emerged as novel regulators of many biological and pathological processes. Recently, an increasing number of dysregulated lncRNAs have been found to be implicated in periodontitis. In this review, an overview of lncRNAs, including their biogenesis, characteristics, function mechanisms and research approaches, is provided. And we summarize recent research reports on the emerging roles of lncRNAs in regulating proliferation, apoptosis, inflammatory responses, and osteogenesis of periodontal cells to elucidate lncRNAs related physiopathology of periodontitis. Furthermore, we have highlighted the underlying mechanisms of lncRNAs in periodontitis pathology by interacting with microRNAs. Finally, the potential clinical applications, current challenges, and prospects of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets for periodontitis disease are discussed.

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Downregulation of Linc‐RNA activator of myogenesis lncRNA participates in FGF2‐mediated proliferation of human periodontal ligament stem cells

Cited by 11 publications

References 15 publications

The Expression and Regulatory Roles of Long Non-Coding RNAs in Periodontal Ligament Cells: A Systematic Review

The Expression and Regulatory Roles of Long Non-Coding RNAs in Periodontal Ligament Cells: A Systematic Review

Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms

Long non‐coding RNAs: Emerging roles in periodontitis

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