Downregulation of LH receptor mRNA in the rat uterus

Kasahara, Yoshimitsu; Kitahara, Yoshikazu; Nakamura, Kazuto; Minegishi, Takashi

doi:10.3892/mmr.2012.795

Cited by 2 publications

(2 citation statements)

References 13 publications

(16 reference statements)

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“…The expression of the hCG/LH-R varies during the cycle, reaching a peak during the secretory phase (Reshef et al 1990, Kasahara et al 2012. The cycledependent expression of the hCG/LH-R suggests that it is modulated by steroid hormones.…”

Section: Effect Of Bpa On Secretion Of Biomarkers Of Endometrial Matumentioning

confidence: 99%

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Bisphenol A modulates receptivity and secretory function of human decidual cells: an in vitro study

Mannelli¹,

Szóstek²,

Łukasik³

et al. 2015

Reproduction

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The human endometrium is a fertility-determining tissue and a target of steroid hormones' action. Endocrine disruptors (EDs) can exert adverse effects on the physiological function of the decidua at the maternal-fetal interface. We examined the potential effects of an ED, bisphenol A (BPA), on endometrial maturation/decidualization, receptivity, and secretion of decidual factors (biomarkers). In vitro decidualized, endometrial stromal cells from six hysterectomy specimens were treated with 1 pM-1 mM of BPA, for 24 h and assessed for cell viability and proliferation. Three non-toxic concentrations of BPA (1 mM, 1 nM, and 1 pM) were selected to study its influence on secretion of cell decidualization biomarkers (IGF-binding protein and decidual prolactin (dPRL)), macrophage migration inhibitory factor (MIF) secretion, and hormone receptors' expression (estrogen receptors (ERa and ERb); progesterone receptors (PRA and PRB); and human chorionic gonadotropin (hCG)/LH receptor (LH-R)). The results showed a decrease in cell viability (P!0.001) in response to BPA at the level of 1 mM. At the non-toxic concentrations used, BPA perturbed the expression of ERa, ERb, PRA, PRB, and hCG/LH-R (P!0.05). Furthermore, 1 mM of BPA reduced the mRNA transcription of dPRL (P!0.05). Secretion of MIF was stimulated by all BPA treatments, the lowest concentration (1 pM) being the most effective (P!0.001). The multi-targeted disruption of BPA on decidual cells, at concentrations commonly detected in the human population, raises great concern about the possible consequences of exposure to BPA on the function of decidua and thus its potential deleterious effect on pregnancy.Reproduction (2015) 150 115-125

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Section: Effect Of Bpa On Secretion Of Biomarkers Of Endometrial Matumentioning

confidence: 99%

“…The b-hCG subunit is secreted by the trophoblast, starting from the earliest stages of gestation (Cole 2009, Handschuh et al 2009, Tsampalas et al 2010, and acts on the endometrium through the hCG/luteinizing hormone receptor (LH-R), playing a key role in embryo implantation (Kasahara et al 2012).…”

Section: The Role Of the Hcg Hormone On Endometrial Receptivitymentioning

confidence: 99%

Bisphenol A modulates receptivity and secretory function of human decidual cells: an in vitro study

Mannelli¹,

Szóstek²,

Łukasik³

et al. 2015

Reproduction

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Koyunlarda Östrus İndüksiyonu Sonrası Ovaryum, Oviduct ve Endometriyumda Folikül Uyarıcı Hormon, Luteotropik Hormon, Östrojen ve Progesteron Reseptör Ekspresyonu

Yang¹,

Xiao-lei²,

Chen³

et al. 2019

Kafkas Univ Vet Fak Derg

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Induction of estrus is an effective management tool for increasing the pregnancy rate in ewes, and there is a long estrus interval after lambing in spring in Small-tail Han ewe. In this study, norgestrel releasing intra-vaginal devices (PRID) and PRID + pregnant mare serum gonadotrophin (PMSG) were used for estrus induction in Small-tail Han ewe, and expression of follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), estrogen receptor (ER) and progesterone receptor (PGR) mRNA in the ovarial stroma, oviduct ampulla and endometrium was analyzed by quantitative real-time PCR. The results showed that the estrus-induction with PRID and PRID + PMSG almost had the same effects on increasing the percentage of animals in estrus and conception rate of the ewes, and the estrus-induction had no significant effect on the expression of LHR, ER and PGR mRNA in the oviduct ampulla, ovarial stroma and endometrium, and FSHR in the ovarial stroma and endometrium. Furthermore, the estrus-induction could significantly decrease the expression of FSHR mRNA in the ovine oviduct ampulla (P<0.05). Therefore, it was suggested that down-regulation of FSHR in the oviduct ampulla after estrus induction may be helpful for fertilization and early embryo development.

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Downregulation of LH receptor mRNA in the rat uterus

Cited by 2 publications

References 13 publications

Bisphenol A modulates receptivity and secretory function of human decidual cells: an in vitro study

Bisphenol A modulates receptivity and secretory function of human decidual cells: an in vitro study

Koyunlarda Östrus İndüksiyonu Sonrası Ovaryum, Oviduct ve Endometriyumda Folikül Uyarıcı Hormon, Luteotropik Hormon, Östrojen ve Progesteron Reseptör Ekspresyonu

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