Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Fang, Zhipeng; Fan, Mingjie; Yuan, Dongqiang; Jin, Lihua; Wang, Yangmeng; Ding, Lili; Xu, Senlin; Tu, J. C.; Zhang, Eryun; Wu, Xiwei; Chen, Zhen Bouman; Huang, Wendong

doi:10.1038/s42003-023-04483-0

Cited by 3 publications

(4 citation statements)

References 46 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric sleeve surgery can prompt the upregulation of tumor suppressor miR‐122 in serum, thus reducing the risk of cancer 274 . In addition, the marked upregulation of lncRNA Gm19619 triggered by a HFD can enhance hepatic gluconeogenesis and lipid accumulation 275 . Following vertical sleeve gastrectomy, the expression of lncRNA Gm19619 is reduced, leading to improved glucose and lipid metabolism 275 .…”

Section: Prevention and Treatment Of Obesity‐associated Diseasesmentioning

confidence: 99%

“…In addition, the marked upregulation of lncRNA Gm19619 triggered by a HFD can enhance hepatic gluconeogenesis and lipid accumulation 275 . Following vertical sleeve gastrectomy, the expression of lncRNA Gm19619 is reduced, leading to improved glucose and lipid metabolism 275 . Sleeve gastrectomy can reverse the upregulation of lncRNA taurine‐upregulated gene 1 (TUG1) induced by high sugar and high fat intake, leading to decreased TUG1 levels which in turn help in regulating blood sugar levels in patients with T2D 276 .…”

Section: Prevention and Treatment Of Obesity‐associated Diseasesmentioning

confidence: 99%

“…275 Following vertical sleeve gastrectomy, the expression of lncRNA Gm19619 is reduced, leading to improved glucose and lipid metabolism. 275 Sleeve gastrectomy can reverse the upregulation of lncRNA taurine-upregulated gene 1 (TUG1) induced by high sugar and high fat intake, leading to decreased TUG1 levels which in turn help in regulating blood sugar levels in patients with T2D. 276 Hence, bariatric surgery presents a promising approach for preventing complications in obese patients.…”

Section: Bariatric Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Epigenetic modifications in obesity‐associated diseases

Long,

Mao,

Liu

et al. 2024

MedComm

View full text Add to dashboard Cite

The global prevalence of obesity has reached epidemic levels, significantly elevating the susceptibility to various cardiometabolic conditions and certain types of cancer. In addition to causing metabolic abnormalities such as insulin resistance (IR), elevated blood glucose and lipids, and ectopic fat deposition, obesity can also damage pancreatic islet cells, endothelial cells, and cardiomyocytes through chronic inflammation, and even promote the development of a microenvironment conducive to cancer initiation. Improper dietary habits and lack of physical exercise are important behavioral factors that increase the risk of obesity, which can affect gene expression through epigenetic modifications. Epigenetic alterations can occur in early stage of obesity, some of which are reversible, while others persist over time and lead to obesity‐related complications. Therefore, the dynamic adjustability of epigenetic modifications can be leveraged to reverse the development of obesity‐associated diseases through behavioral interventions, drugs, and bariatric surgery. This review provides a comprehensive summary of the impact of epigenetic regulation on the initiation and development of obesity‐associated cancers, type 2 diabetes, and cardiovascular diseases, establishing a theoretical basis for prevention, diagnosis, and treatment of these conditions.

show abstract

Section: Prevention and Treatment Of Obesity‐associated Diseasesmentioning

confidence: 99%

Section: Prevention and Treatment Of Obesity‐associated Diseasesmentioning

confidence: 99%

Section: Bariatric Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Epigenetic modifications in obesity‐associated diseases

Long,

Mao,

Liu

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

“…Fang et al 86 determined the biological function of Gm19619, which has never been investigated. Hepatic Gm19619 is highly upregulated by diet-induced obesity and overnight fasting in mice but is dramatically repressed by vertical sleeve gastrectomy, which is one of the most common and effective surgeries for sustained weight loss, remission of diabetes, and other comorbidities, including NAFLD.…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Recent insights into the pathogenesis and therapeutic targets of chronic liver diseases

Wen,

Ma,

2023

egastro

View full text Add to dashboard Cite

Viral hepatitis, alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the three major causes of chronic liver diseases, which account for approximately 2 million deaths per year worldwide. The current direct-acting antiviral drugs and vaccinations have effectively reduced and ameliorated viral hepatitis infection, but there are still no effective drug treatments for ALD, NAFLD and liver cancer due to the poor understanding of their pathogenesis. To better understand the pathogenesis, the fifth Chinese American Liver Society/Society of Chinese Bioscientists in America Hepatology Division Annual Symposium, which was held virtually on 21–22 October 2022, focused on the topics related to ALD, NAFLD and liver cancer. Here, we briefly highlight the presentations that focus on the current progress in basic and translational research in ALD, NAFLD and liver cancer. The roles of non-coding RNA, autophagy, extrahepatic signalling, macrophages, etc in liver diseases are deliberated, and the application of single-cell RNA sequencing in the study of liver disease is also discussed.

show abstract

The Long Non‐Coding RNA Obesity‐Related (Obr) Contributes To Lipid Metabolism Through Epigenetic Regulation

Kaimala,

Lootah,

Mehra

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Obesity is a multifactorial disease that is part of today's epidemic and also increases the risk of other metabolic diseases. Long noncoding RNAs (lncRNAs) provide one tier of regulatory mechanisms to maintain metabolic homeostasis. Although lncRNAs are a significant constituent of the mammalian genome, studies aimed at their metabolic significance, including obesity, are only beginning to be addressed. Here, a developmentally regulated lncRNA, termed as obesity related (Obr), whose expression in metabolically relevant tissues such as skeletal muscle, liver, and pancreas is altered in diet‐induced obesity, is identified. The Clone 9 cell line and high‐fat diet‐induced obese Wistar rats are used as a model system to verify the function of Obr. By using stable expression and antisense oligonucleotide‐mediated downregulation of the expression of Obr followed by different molecular biology experiments, its role in lipid metabolism is verified. It is shown that Obr associates with the cAMP response element‐binding protein (Creb) and activates different transcription factors involved in lipid metabolism. Its association with the Creb histone acetyltransferase complex, which includes the cAMP response element‐binding protein (CBP) and p300, positively regulates the transcription of genes involved in lipid metabolism. In addition, Obr is regulated by Pparγ in response to lipid accumulation.

show abstract

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Cited by 3 publications

References 46 publications

Epigenetic modifications in obesity‐associated diseases

Epigenetic modifications in obesity‐associated diseases

Recent insights into the pathogenesis and therapeutic targets of chronic liver diseases

The Long Non‐Coding RNA Obesity‐Related (Obr) Contributes To Lipid Metabolism Through Epigenetic Regulation

Contact Info

Product

Resources

About