Abstract:Correspondence should be addressed to Lingjun Zhan (Zhanlj@cnilas.org) and Chuan Qin (qinchuan@pumc.edu.cn).Abstract GPR183/EBI2 is a key chemotactic receptor for the positioning of B cells in lymphoid organs, and also for the migration of T cells and other immune cells. Here, we demonstrate that the downregulation of GPR183 in macrophage induced during Mtb infection restrains the bacterial early infection and intracellular survival. Overexpression of GPR183 or stimulation with its natural ligand favors Mtb su… Show more
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