Downregulation of EIF4A2 in Non–Small-Cell Lung Cancer Associates with Poor Prognosis

Xi, Shaoyan; Yong, Juanjuan; Tao, Yiming; He, Ping; Liang, Jing; Wu, Qing

doi:10.1016/j.cllc.2013.04.011

Cited by 35 publications

(29 citation statements)

References 23 publications

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“…EIF4A2 is involved in the progression of breast cancer and melanoma [37] and in the development of non-small-cell lung cancer, and has been suggested as a potential prognostic marker [38]. …”

Section: Resultsmentioning

confidence: 99%

SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression

Huang

et al. 2016

Oncotarget

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The Epstein–Barr virus (EBV) is associated with a variety of cancers, including gastric cancer, which has one of the highest mortality rates of all human cancers. Long non-coding RNAs (lncRNAs) have been suggested to have important causal roles in gastric cancer. However, the interaction between lncRNAs and EBV has not yet been studied. To this end, we sequenced 11,311 lncRNAs and 144,826 protein-coding transcripts from four types of tissue: one non-EBV-infected gastric carcinoma (EBVnGC) and its adjacent normal tissue, and one EBV-associated gastric carcinoma (EBVaGC) and its adjacent normal tissue. Five lncRNAs showed EBVaGC-specific expression; of those, one (SNHG8) was validated using real-time PCR in an independent cohort with 88 paired gastric cancer and adjacent tissue samples. To explore the functions of SNHG8, we identified its mRNA targets on the lncRNA–mRNA co-expression network of the Illumina Body Map, which contains the RNA sequencing data of mRNAs and lncRNAs from 16 normal human tissues. SNHG8 lncRNA was found to affect several gastric cancer-specific pathways and target genes of EBV. Our results reveal the intertwined tumorigenesis mechanisms of lncRNA and EBV and identify SNHG8 as a highly possible candidate biomarker and drug target of gastric cancer.

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Section: Resultsmentioning

confidence: 99%

SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression

Huang

et al. 2016

Oncotarget

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show abstract

“…eIF4A1 is expressed at higher levels in dividing cells, whereas eIF4A2 is up-regulated in growtharrested states [10]. The expression of eIF4A1 is up-regulated in a range of malignancies [11][12][13][14] (Table 1); in contrast, high eIF4A2 levels in human tumours are associated with better outcome [15,16]. This variable requirement of the two isoforms suggests differences in their roles in proliferation.…”

Section: Eif4a Isoforms and Their Regulationmentioning

confidence: 88%

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

Raza

Waldron

Quesne

2015

Biochemical Society Transactions

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The malignant phenotype is largely the consequence of dysregulated gene expression. Transformed cells depend upon not just a global increase in protein synthesis but an altered translational landscape in which pro-oncogenic mRNAs are translationally up-regulated. Such mRNAs have been shown to possess longer and more structured 5'-UTRs requiring high levels of eukaryotic initiation factor 4A (eIF4A) helicase activity for efficient translation. As such there is a developing focus on targeting eIF4A as a cancer therapy. In order for such treatments to be successful, we must develop a detailed understanding of the mechanisms which make specific mRNAs more dependent on eIF4A activity than others. It is also crucial to fully characterize the potentially distinct roles of eIF4A1 and eIF4A2, which until recently were thought to be functionally interchangeable. This review will highlight the recent advances made in this field that address these issues.

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“…Despite recent advances in cancer therapy, the 5-year survival rate of patients with NSCLC remains to be just 16% (2). The development of lung cancer is a multistep process, which requires the contribution of numerous oncogenes and tumor suppressors (3)(4)(5). However, the underlying mechanism of NSCLC development remains unknown.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑139‑5p inhibits cell viability, migration and invasion and suppresses tumor growth by targeting HDGF in non‑small cell lung cancer

Zhang

Jiang

et al. 2020

Oncol Lett

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MicroRNA (miRNAs) serve key roles in the progress of various types of cancer. The expression of miRNA (miR)-139-5p is downregulated in several types of tumor and has been recognized as a tumor suppressor. However, the role of miR-139-5p in non-small cell lung cancer (NSCLC) has not been investigated in detail. In the present study, it was demonstrated that miR-139-5p was significantly downregulated in NSCLC cells and tissues, and the overexpression of miR-139-5p in vitro induced apoptosis and significantly inhibited the viability and proliferation of A549 and H1299 cells. In addition, upregulation of miR-139-5p significantly inhibited the migration and invasion of A549 and H1299 cells. Hepatoma-derived growth factor (HDGF) was identified as a direct target of miR-139-5p. Rescue experiments demonstrated that the inhibitory function of miR-139-5p on cell viability, migration and invasion was partially mediated by suppressing HDGF expression. Furthermore, miR-139-5p exhibited efficient inhibition of tumor growth in a xenograft tumor mouse model of A549 cells. In summary, the results from the present study suggested that miR-139-5p may serve an important role in NSCLC by targeting HDGF and causing inhibition of cell viability and metastasis, as well as induction of apoptosis. miR-139-5p may also have the potential to serve as a therapeutic target for the treatment of NSCLC.

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Downregulation of EIF4A2 in Non–Small-Cell Lung Cancer Associates with Poor Prognosis

Cited by 35 publications

References 23 publications

SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression

SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression

Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence

MicroRNA‑139‑5p inhibits cell viability, migration and invasion and suppresses tumor growth by targeting HDGF in non‑small cell lung cancer

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