Downregulation of CPSF6 leads to global mRNA 3’ UTR shortening and enhanced antiviral immune responses
Yong Ge,
Jingrong Huang,
Rong Chen
et al.
Abstract:Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3’ untranslated regions (3’ UTRs). Our previous study has revealed the global 3’ UTR shortening of host mRNAs through APA upon viral infection. However, how the dynamic changes in the APA landscape occur upon viral infection remains largely unknown. Here we further found that, the reduced protein abundance of CPSF6, one of the core 3’ processing factors, promotes the usage of proximal po… Show more
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