Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/β-catenin pathway and EMT in cutaneous squamous cell carcinomas

Li, Xiangzhi; Zhang, Chen; Yuan, Yafei; Wang, Yimeng; Lu, Sheng; Zhou, Zhaoming; Zhen, Peilin; Zhou, Meijuan

doi:10.1016/j.jdermsci.2021.05.002

Cited by 10 publications

(5 citation statements)

References 28 publications

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“…The CTLH complex is involved in numerous cellular pathways ( 7 ) including signaling processes like regulating sonic hedgehog components ( 8 ) at the primary cilium ( 9 , 10 ) degradation of c-Raf in the extracellular signal–regulated kinase pathway ( 11 ), and CTLH subunits were also linked to the Wnt-signaling pathway ( 12 , 13 , 14 ). Dysregulation of CTLH components correlates with poor prognosis and tumor progression in various cancer types ( 15 , 16 , 17 , 18 , 19 ).…”

mentioning

confidence: 99%

RanBP9 controls the oligomeric state of CTLH complex assemblies

Hassend¹,

Pottikkadavath²,

Delto³

et al. 2023

Journal of Biological Chemistry

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mentioning

confidence: 99%

RanBP9 controls the oligomeric state of CTLH complex assemblies

Hassend¹,

Pottikkadavath²,

Delto³

et al. 2023

Journal of Biological Chemistry

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“…RUNX2, a gene most associated with cartilage production, has been linked to pancreatic cancer and to breast cancer progression through modulation of MicroRNAs and the metastasis-associated 1 (MTA1)/NuRD complex [38,39]. By activating the Wnt signaling pathway, ARMC8 has been linked to increased invasion in cutaneous squamous cell carcinoma and lung cancer [40][41][42]. Also implicated in the Wnt pathway, as well as the VEGF pathway, CEMIP (formerly known as KIA1199) has emerged via immunohistochemical studies as a possible biomarker for a variety of cancers [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Survival and Enrichment Analysis of Epithelial–Mesenchymal Transition Genes in Bladder Urothelial Carcinoma

Ali,

Xiao,

Jacobs

et al. 2023

Genes

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The escalating prevalence of bladder cancer, particularly urothelial carcinoma, necessitates innovative approaches for prognosis and therapy. This study delves into the significance of genes related to epithelial–mesenchymal transition (EMT), a process inherently linked to carcinogenesis and comparatively better studied in other cancers. We examined 1184 EMT-related gene expression levels in bladder urothelial cancer cases through the TCGA dataset. Genes shown to be differentially expressed in relation to survival underwent further network and enrichment analysis to uncover how they might shape disease outcomes. Our in silico analysis revealed a subset of 32 genes, including those significantly represented in biological pathways such as VEGF signaling and bacterium response. In addition, these genes interact with genes involved in the JAK-STAT signaling pathway. Additionally, some of those 32 genes have been linked to immunomodulators such as chemokines CCL15 and CCL18, as well as to various immune cell infiltrates. Our findings highlight the prognostic utility of various EMT-related genes and identify possible modulators of their effect on survival, allowing for further targeted wet lab research and possible therapeutic intervention.

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“…The canonical Wnt pathway is involved in the epithelial–mesenchymal transition (EMT), which is essential for the invasion and progression of tumors [ 79 ]. The connections between E-cadherin and β-catenin play a central role in this process.…”

Section: Wnt and Keratinocyte Carcinomas: From Actinic Keratosis To C...mentioning

confidence: 99%

Wnt Signaling Pathways: From Inflammation to Non-Melanoma Skin Cancers

Bartolomeo

Vaccaro

Irrera

et al. 2023

IJMS

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Canonical and non-canonical Wnt signaling pathways are involved in cell differentiation and homeostasis, but also in tumorigenesis. In fact, an exaggerated activation of Wnt signaling may promote tumor growth and invasion. We summarize the most intriguing evidence about the role of Wnt signaling in cutaneous carcinogenesis, in particular in the pathogenesis of non-melanoma skin cancer (NMSC). Wnt signaling is involved in several ways in the development of skin tumors: it may modulate the inflammatory tumor microenvironment, synergize with Sonic Hedgehog pathway in the onset of basal cell carcinoma, and contribute to the progression from precancerous to malignant lesions and promote the epithelial-mesenchymal transition in squamous cell carcinoma. Targeting Wnt pathways may represent an additional efficient approach in the management of patients with NMSC.

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Downregulation of ARMC8 promotes tumorigenesis through activating Wnt/β-catenin pathway and EMT in cutaneous squamous cell carcinomas

Cited by 10 publications

References 28 publications

RanBP9 controls the oligomeric state of CTLH complex assemblies

RanBP9 controls the oligomeric state of CTLH complex assemblies

Survival and Enrichment Analysis of Epithelial–Mesenchymal Transition Genes in Bladder Urothelial Carcinoma

Wnt Signaling Pathways: From Inflammation to Non-Melanoma Skin Cancers

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