Downregulation of Angiogenin Transcript Levels and Inhibition of Colonic Carcinoma by Gum Arabic (<i>Acacia senegal</i>)

Nasir, Omaima; Wang, Kan; Föller, Michael; Bhandaru, Madhuri; Sandulache, Diana; Artunc, Ferruh; Ackermann, Teresa F.; Ebrahim, Ammar M.; Palmada, Mònica; Klingel, Karin; Saeed, Amal; Läng, Florian

doi:10.1080/01635581003605920

Cited by 31 publications

(25 citation statements)

References 55 publications

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“…3) and ß-catenin expression [79]. Chemical cancerogenesis by intraperitoneal injection of 20 mg/kg 1,2-dimethylhydrazine followed by 3 cycles of 3% dextrane sodium sulphate in drinking water results in the development of multiple colonic tumors, an effect significantly blunted by GA treatment [79]. Those observations disclose a powerful anticarcinogenic effect of GA treatment, which could be exploited for prophylaxis or treatment of colon carcinoma [79].…”

Section: Extrarenal Effects Of Gamentioning

confidence: 99%

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Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Nasir

2013

Kidney Blood Press Res

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1,741

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Gum arabic (GA), a water-soluble dietary fiber rich in Ca²⁺, Mg²⁺ and K⁺, is used in Middle Eastern countries for the treatment of patients with chronic kidney disease. Recent animal experiments shed some light into mechanisms involved in the therapeutic action of GA. According to experiments in healthy mice, GA treatment increases creatinine clearance, enhances renal excretion of ADH, Mg²⁺ and Ca²⁺, decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na⁺. In diabetic mice GA treatment increases urinary Ca²⁺ excretion, and decreases plasma phosphate concentration, plasma urea concentration, urinary flow rate, natriuresis, phosphaturia, glucosuria, proteinuria as well as blood pressure. Extrarenal effects of GA treatment in mice include decreased expression of intestinal Na⁺ coupled glucose carrier SGLT1 with subsequent delay of electrogenic intestinal glucose transport, glucose-induced hyperglycemia, hyperinsulinemia and body weight gain. GA treatment decreases colonic transcription of the angiogenetic factors angiogenin 1, angiogenin 3 and angiogenin 4, of CD38 antigen, aquaporin4, interleukin18, vav-3-oncogene, y⁺-amino acid-transporter, sulfatase1, ubiquitinD and chemokine ligand5. Moreover, GA treatment decreases angiogenin and ß-catenin protein expression. Accordingly, GA treatment counteracts the development of tumors following chemical cancerogenesis. In mouse dendritic cells, antigen-presenting cells linking innate and adaptive immunity, GA treatment modifies maturation and cytokine release. GA treatment further favourably influences the course of murine malaria. The effects of GA treatment on plasma phosphate concentration, blood pressure and proteinuria may prove beneficial in chronic renal failure and diabetic nephropathy. The effect of GA on intestinal glucose transport may be useful in the prophylaxis and treatment of obesity and diabetes, the effect of GA on angiogenin and ß-catenin expression could be exploited for the prophylaxis against colon carcinoma, the effects of GA on angiogenin expression and dendritic cells may be useful in the treatment of inflammatory disease and malaria.

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Section: Extrarenal Effects Of Gamentioning

confidence: 99%

Section: Extrarenal Effects Of Gamentioning

confidence: 99%

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Nasir

2013

Kidney Blood Press Res

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1,741

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“…In the present study, the gum arabic was added as stabilizer, emulsifier because of availability in Sudan. Gum arabic is dietary fiber that is derived from dried exudates of Acacia senegal (Nasir et al, 2010). The use of gum arabic; although small proportion was used; might also add some nutrition value to ice cream in addition to its health benefit (Gamal El-Din et al, 2003;Elkhidir et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Processing Properties and Chemical Composition of Low Fat Ice Cream Made from Camel Milk Using Natural Additives

Ahmed¹,

Zubeir²

2015

International J. of Dairy Science

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This study is a trial to process ice cream from camel milk using natural additives (honey and gum arabic) and flavored with vanilla, coconut and their combination. The processed ice cream was packed into plastic cups and stored at -18°C for eight weeks, the chemical evaluation was carried out every week. The results showed significantly higher total solids and fat content in the combination of vanilla and coconut ice cream samples, while the high ash content was found in vanilla ice cream samples. The present study concluded that ice cream could be produced from camel milk.

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“…It stimulates sodium and water absorption in diarrhea. GA also affect colonic tissue [64] when provided (10% wt/vol) in drinking water. It modifies several tumor-relevant genes and significantly decreased the number of tumors by 70%.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…GA when provided with nutrients work as good prophylaxis agent against colon carcinoma. [64] Normally, curcumin is used in the treatment of colon cancer, but it shows very poor absorption in the upper part of the gastrointestinal tract (GIT). [65] Curcumin containing polymer (GG)-based matrix tablets are delivered to the colon for effective treatment of colon cancer.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Untitled

Upadhyay

2017

IJGP

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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also used in food, pharmaceutical, paper textile, and other industries. The present review also explains various biological activities such as antidiarrheic, antitumor, anti-inflammatory, anti-arthritic, antiparasitic, gastrourinary, antitumor, antiparasitic, antioxidant, chemopreventive, and gastroprotective activity of plant gums. These reduce stomach inflammation, system cleansing or to settle the intestines. Other uses for mesquite gum include treatment for lice, sore throat, cough, laryngitis, fever reduction, painful gums, and hemorrhoids and it can be used as a purgative. Gum arabic is a water-soluble dietary fiber rich in Ca , and decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na + . Gums are used as adhesives, crystallization inhibitors, emulsifying agents, emulsion stabilizers, encapsulating agents, film formers, foam stabilizers, suspending agents, suspension stabilizers, or syneresis inhibitors and impart other specific properties. The gum is also used to a limited extent in polishes, contact insecticides and pesticides, photographic emulsions, and pharmaceuticals. This article suggests wider use of plant gums in generation of drug delivery system for cancer and brain tumor therapy. There is no doubt that chemical constituents of plant gums can be largely used for making therapeutic drugs because of their broadspectrum biological effectiveness.

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Downregulation of Angiogenin Transcript Levels and Inhibition of Colonic Carcinoma by Gum Arabic (Acacia senegal)

Cited by 31 publications

References 55 publications

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Processing Properties and Chemical Composition of Low Fat Ice Cream Made from Camel Milk Using Natural Additives

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