Downregulated StAR gene and male reproductive dysfunction caused by nifedipine and ethosuximide

Ebiya, Rasha A.; Montaser, Metwally M.; Darwish, Samia M.

doi:10.1016/j.jobaz.2016.12.005

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…In their study, there was total atrophy, disruption, severe damage, and elongation of seminiferous tubules with disorganisation of germinal epithelium that detached from the basement membrane. However, in contrast to the previous report of Ebiya et al., (2016), the lumen of seminiferous tubules in this study showed partial absence of sperm cells, while it was total vacuolation in the lumen of the seminiferous tubule in their report of Ebiya and co‐workers.…”

Section: Discussioncontrasting

confidence: 99%

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Carbamazepine adversely altered the pituitary–testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine–levetiracetam adjuvant treatment in male Wistar rat

et al. 2020

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This study investigated the on‐toward reactions of individual or adjunctive treatment with carbamazepine (CBZ) and levetiracetam (LEV) on the pituitary–testicular axis in male rats. Twenty‐four male Wistar rats were randomised into 4 groups (n = 6) and received daily intraperitoneal (i.p) treatment of normal saline (0.1 ml/day); CBZ (25 mg/kg i.p); LEV (50 mg/kg i.p); or combination of CBZ (12.5 mg/kg) and LEV (25 mg/kg) for 4 weeks. The serum concentration of luteinising hormone (LH), follicle‐stimulating hormone (FSH), and testosterone was determined. Also, the seminal profile and histomorphological status of the testis were determined. Data were analysed using descriptive and inferential statistics. The control and test groups were compared using Student's t test, analysis of variance (ANOVA), and Student–Newman–Keuls post hoc analysis where appropriate, while the results presented as mean ± SEM in graphs or tables. The level of significance was taken at p < .05. The percentage motility, viability, and concentration of FSH decreased significantly in all the treatment groups, while the testis was presented with various forms of histomorphological aberrations. This study concludes that CBZ, and CBZ + LEV adjunctive treatments alter the pituitary–testicular axis with evidence of hormonal deregulation and alteration in the reproductive functions' indices, while LEV treatment remains the safest.

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Section: Discussioncontrasting

confidence: 99%

“…Ebiya et al. (2016) reported a similar effect on the histomorphological profile of the testis following higher doses of LEV. In their study, there was total atrophy, disruption, severe damage, and elongation of seminiferous tubules with disorganisation of germinal epithelium that detached from the basement membrane.…”

Section: Discussionmentioning

confidence: 79%

Carbamazepine adversely altered the pituitary–testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine–levetiracetam adjuvant treatment in male Wistar rat

et al. 2020

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“…The change in the transcript level of induced iNOS and Casp3 genes was quantified using qRTPCR [97,98]. Total RNA was extracted from ovarian tissues using Direct-zol RNA Miniprep Plus (Cat# R2072, ZYMO Research Corp. Tucson, Arizona USA).…”

Section: Qrtpcr For Determination Of Inos and Casp3 Expression Levelsmentioning

confidence: 99%

Ameliorative Effect of Citrus Lemon Peel Extract and Resveratrol on Premature Ovarian Failure Rat Model: Role of iNOS/Caspase-3 Pathway

et al. 2022

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Premature ovarian failure (POF) is described as a loss of oocytes and the absence of folliculogenesis and is considered an adverse effect of chemotherapeutic drugs, which leads to infertility. Subsequently, the existing inquiry was achieved by exploring the potential suspicious influences of lemon peel extract (LPE), and resveratrol (RES) on cyclophosphamide (CPA) induced-POF. The results showed that CPA-induced POF significantly decreased serum estradiol (E2) and progesterone levels, along with a considerable rise in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. Moreover, CPA administration to rats significantly increased the serum level of Malondialdehyde (MDA) and significantly lowered the levels of reduced glutathione (GSH) and superoxide dismutase (SOD); in addition, it increased nuclear factor kappa B (NF-κB) levels, tumor necrosis factor-α (TNF-α), as well as cyclooxygenase 2 (COX-2) with the spread expression of inducible nitric oxide synthase (iNOS) mRNA levels and caspase-3 (Casp3) levels in ovarian tissues versus the control rats. However, treatment with LPE and RES suppressed the triggering of NF- κB pathways, evidenced by a considerable reduction in Casp3 & iNOS mRNA expression level and significant ameliorative effects in all evaluated parameters, as confirmed by the histological and immunohistochemical investigation when comparing the model group. In overall findings, both lemon peel extract and resveratrol can mitigate the adverse effects of CPA-induced POF. Most crucially, its combination therapy is a promising pharmacological agent for this disease.

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“…StAR protein expression is regulated by LH-mediated activation of cAMP-dependent pathways, leading to transcriptional activation in Leydig cells [63]. StAR expression is correlated to stress on testis, which affect its efficiency [64][65][66]. The current results recorded an improvement in testis efficiency in the groups treated with stem cells and beetroot extract after Cis treatment considering the expression levels of the StAR gene.…”

Section: Discussionmentioning

confidence: 73%

Molecular, Immunomodulatory, and Histopathological Role of Mesenchymal Stem Cells and Beetroot Extract on Cisplatin Induced Testicular Damage in Albino Rats

Hassen

Mohamed

Montaser

et al. 2021

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Cisplatin (Cis) a drug commonly used as a chemotherapeutic agent to treat various types of cancer, inducing testicular damage. The present study aimed to investigate the inhibitory potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) and beetroot extract (BRE) in albino rats after testicular toxicity induced by cisplatin. Thirty adult male albino rats were grouped into: the control group, Cis group receiving a single dose of 7 mg/kg i.p. (intraperitoneal) to induce testicular toxicity, Cis plus BM-MSCs injected Cis followed by 2 × 106 of BM-MSCs; Cis plus BRE group receiving Cis followed by 300 mg/kg body weight/day of BRE, and Cis plus BM-MSCs and BRE group. In the current study, Cis reduced sperm count, serum testosterone level, and testicular activity of alkaline phosphatase (AKP), besides a marked inhibition of succinate dehydrogenase (SDH) activity. In addition, it significantly increased malondialdehyde (MDA) and along with a marked decrease in testis reduced glutathione content and total antioxidant capacity (TAC). At the same time, Cis administration resulted in a marked elevation in interleukine-6 and the iNOS and caspase-3 genes; however, it decreased the expression of steroidogenic acute regulatory protein (StAR). Combined treatment with BM-MSCs and BRE resulted in great improvement of all previous parameters. These results were also confirmed by histopathological and immunohistochemical examination. In conclusion, both MSCs and BRE were found to have potent potentials to inhibit testicular damage induced by cisplatin.

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Downregulated StAR gene and male reproductive dysfunction caused by nifedipine and ethosuximide

Cited by 6 publications

References 46 publications

Carbamazepine adversely altered the pituitary–testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine–levetiracetam adjuvant treatment in male Wistar rat

Carbamazepine adversely altered the pituitary–testicular axis with resultant reproductive dysfunctions than levetiracetam or carbamazepine–levetiracetam adjuvant treatment in male Wistar rat

Ameliorative Effect of Citrus Lemon Peel Extract and Resveratrol on Premature Ovarian Failure Rat Model: Role of iNOS/Caspase-3 Pathway

Molecular, Immunomodulatory, and Histopathological Role of Mesenchymal Stem Cells and Beetroot Extract on Cisplatin Induced Testicular Damage in Albino Rats

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