Downregulated miR-367-3p, miR-548aq-5p, and miR-4710 in Human Whole Blood: Potential Biomarkers for Breast Cancer With Axillary Lymph Node Metastasis

Dysregulated expression of miR‑367 in disease development and its prospects as a therapeutic target and diagnostic biomarker (Review)

“…The presence of ALNM is a critical factor in determining the prognosis of patients with breast cancer and ALNs are the most common site for breast cancer metastasis (39). The results of the study demonstrated that low expression of miR-367-3p was associated with positive ALNM, larger tumor size and a more advanced tumor-node-metastasis stage (30). In addition, a study conducted by Liu et al (31) revealed a strong association between miR-367 expression and the clinicopathologic features and prognosis of breast cancer.…”

“…Extensive cancer research has focused on miR-367, which has demonstrated tumor-suppressing activity through the targeting of oncogenes. In multiple types of cancer, including breast (30)(31)(32), gastric (33,34) and prostate cancer (35), higher levels of miR-367 have been associated with improved prognoses and survival rates. In addition, miR-367 has been recognized as a possible biomarker for diagnosing various types of cancer including breast (30,31) and gastric (33) cancer (Fig.…”

“…Breast cancer is a common cancer mainly found in women, accounting for 11.7% of all cancer diagnoses and 6.9% of cancer-related deaths globally in women (36). Studies have shown that miRNAs can be either upregulated (37) or downregulated (30,31) in patients with breast cancer and different levels can distinguish these patients from healthy individuals. Studies have shown that miR-367 is involved in the development and progression of breast cancer, and its dysregulation has been implicated in various aspects of breast cancer biology, including cell proliferation, apoptosis, invasion and metastasis (32,38).…”

“…In a recent study, Yang et al (30) discovered that miR-367-3p expression was significantly downregulated in the whole blood samples of patients with breast cancer with axillary lymph node metastasis (ALNM). This finding was particularly significant as it highlighted the potential diagnostic value of miR-367-3p in distinguishing between patients with breast cancer with or without ALNM.…”

“…The study found that miR-367-3p could induce apoptosis and suppress migration of MCF-7 cells by downregulating the expression of human choline kinase α, a key enzyme involved in breast cancer progression. Furthermore, bioinformatics analysis demonstrated that miR-367-3p was related to numerous potential targets, such as metal regulatory transcription factor 1 and phosphatase and tensin homolog, and multiple tumor-related pathways, including cell adhesion molecules, mammalian target of rapamycin and cellular senescence pathways, suggesting that it may play a crucial role in the development and progression of breast cancer (30). Overall, these findings highlight the potential clinical utility of miR-367-3p as a diagnostic marker and its potential role in breast cancer pathology.…”