Downgrading and Upgrading Gray-Scale Ultrasound BI-RADS Categories of Benign and Malignant Masses With Optoacoustics: A Pilot Study

Neuschler, Erin; Lavin, Philip T.; Tucker, F. Lee; Barke, Lora D.; Bertrand, Margaret L.; Böhm-Vélez, Marcela; Destounis, Stamatia; Dogan, Basak E.; Grobmyer, Stephen R.; Katzen, Janine; Kist, Kenneth; Makariou, Erini; Parris, Tchaiko M.; Young, Catherine A.; Butler, Reni

doi:10.2214/ajr.17.18436

Cited by 26 publications

(20 citation statements)

References 29 publications

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“…The dual mode PA US imaging technology can potentially improve specificity in differentiating between malignant and benign breast masses, which can reduce the number of benign breast mass biopsies as well as false-positive examinations. Neuschler et al [112] performed a multicenter in vivo study with their dual mode PA-US imaging system on 94 breast masses. They found that the dual mode system showed 7.9% improvement in specificity compared to their US imaging system, whereas the sensitivities of both PA-US, as well as only the US system, were 97.1%.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

2020

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In this review article, a detailed chronological account of the research related to photoacoustic imaging for the management of breast cancer is presented. Performing a detailed analysis of the breast cancer detection related photoacoustic imaging studies undertaken by different research groups, this review attempts to present the clinical evidence in support of using photoacoustic imaging for breast cancer detection. Based on the experimental evidence obtained from the clinical studies conducted so far, the performance of photoacoustic imaging is compared with that of conventional breast imaging modalities. While we find that there is enough experimental evidence to support the use of photoacoustic imaging for breast cancer detection, additional clinical studies are required to be performed to evaluate the diagnostic potential of photoacoustic imaging for identifying different types of breast cancer. To establish the utility of photoacoustic imaging for breast cancer screening, clinical studies with high-risk asymptomatic patients need to be done.

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Section: In Vivo Studiesmentioning

confidence: 99%

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

2020

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“…[1][2][3][4][5][6] For breast cancer diagnosis, one promising technique is OA imaging combined with ultrasound (OA/US). [7][8][9][10][11][12][13][14][15][16][17][18][19][20] Combining OA with ultrasound is advantageous because each modality provides information that is complementary to the other. Structural and functional information pertaining to total hemoglobin concentration (c tHb ) and blood oxygen saturation (s O 2 ) can be visualized with OA, while morphological and anatomical information can be obtained with ultrasound.…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26][27][28] Since OA directly visualizes c tHb and s O 2 , this can potentially give clinicians the ability to perform more accurate diagnosis. [7][8][9][10][11][12][13][14][15] In OA/US, the probe also acquires conventional ultrasound images, which are coregistered and displayed simultaneously with OA.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13][14][15][16][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Scanning devices include full-breast threedimensional (3-D) imaging systems, [29][30][31][32][33][34][35][36][37][38][39][40][41] as well as real-time two-dimensional (2-D) handheld technologies. [7][8][9][10][11][12][13][14][15][16][17][18]42,43 To date, the largest clinical effort surrounds the Imagio ® breast imaging system (Seno Medical ...…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11][12][13][14][15][16][17][18]42,43 To date, the largest clinical effort surrounds the Imagio ® breast imaging system (Seno Medical Instruments, Inc., San Antonio, Texas), a 2-D system which has evaluated breast lesions in over 2000 subjects. [7][8][9][10][11][12][13][14][15][16]19 The system displays qualitative OA/US maps to visualize areas of strong relative s O 2 and c tHb using a statistical color mapping technique. 44 The OA/US image maps from a malignant lesion are shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Opto-acoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis

et al. 2019

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Opto-acoustic imaging involves using light to produce sound waves for visualizing blood in biological tissue. By using multiple optical wavelengths, diagnostic images of blood oxygen saturation and total hemoglobin are generated using endogenous optical contrast, without injection of any external contrast agent and without using any ionizing radiation. The technology has been used in recent clinical studies for diagnosis of breast cancer to help distinguish benign from malignant lesions, potentially reducing the need for biopsy through improved diagnostic imaging accuracy. To enable this application, techniques for mapping oxygen saturation differences within tissue are necessary. Using biologically relevant opto-acoustic phantoms, we analyze the ability of an opto-acoustic imaging system to display colorized parametric maps that are generated using a statistical mapping approach. To mimic breast tissue, a material with closely matching properties for optical absorption, optical scattering, acoustic attenuation, and speed of sound is used. The phantoms include two vessels filled with whole blood at oxygen saturation levels determined using a sensor-based approach. A flow system with gas-mixer and membrane oxygenator adjusts the oxygen saturation of each vessel independently. Datasets are collected with an investigational Imagio ® breast imaging system. We examine the ability to distinguish vessels as the oxygen saturation level and imaging depth are varied. At depth of 15 mm and hematocrit of 42%, a sufficient level of contrast to distinguish between two 1.6-mm diameter vessels was measured for an oxygen saturation difference of ∼4.6%. In addition, an oxygenated vessel was visible at a depth of 48 mm using an optical wavelength of 1064 nm, and a deoxygenated vessel was visible to a depth of 42 mm with 757 nm. The results provide insight toward using color mapped opto-acoustic images for diagnosing breast cancer.

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Photoacoustic Imaging of Breast Cancer

Matsumoto

Toi

2023

Screening and Risk Reduction Strategies for Breast Cancer

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Downgrading and Upgrading Gray-Scale Ultrasound BI-RADS Categories of Benign and Malignant Masses With Optoacoustics: A Pilot Study

Abstract: Optoacoustic ultrasound resulted in BI-RADS category downgrading of benign masses and upgrading of malignant masses compared with gray-scale ultrasound.

Cited by 26 publications

References 29 publications

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

Opto-acoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis

Photoacoustic Imaging of Breast Cancer

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