Down regulation of TRAIL and FasL on NK cells by Cyclosporin A in renal transplantation patients

Zhang, Yun; Cheng, Guang; Xu, Zhuwei; Li, Zhouli; Song, Chaojun; Li, Qi; Chen, Lihua; Yang, Kun; Yang, Angang; Jin, Boquan

doi:10.1016/j.imlet.2013.03.002

Cited by 12 publications

(4 citation statements)

References 28 publications

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“…Of note, apoptosis triggered by TRAIL expressed on NK cells has been associated with transplant rejection [190]. Indeed, immunosuppressive therapy with cyclosporin A administration after renal transplantation may inhibit solid graft rejection partially by downregulating the expression of TRAIL and FasL on NK cells [191]. However, TRAIL on hepatic NK cells might also have a protective role during liver transplantation, through the elimination of activated T cells [192] ( Figure 2A).…”

Section: Accepted Articlementioning

confidence: 99%

The multifaceted role of TRAIL signaling in cancer and immunity

et al. 2020

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2 Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF 3 superfamily that can lead to the induction of apoptosis in tumor or infected cells. However, activation 4 of TRAIL signaling may also trigger non-apoptotic pathways in cancer and in non-transformed cells, 5 i.e. immune cells. Here, we review the current knowledge on non-canonical TRAIL signaling. The 6 biological outcomes of TRAIL signaling in immune and malignant cells is presented and explained, 7 with a focus on the role of TRAIL for natural killer (NK) cell function. Furthermore, we highlight the 8 technical difficulties in dissecting the precise molecular mechanisms involved in the switch between 9 apoptotic and non-apoptotic TRAIL signaling. Finally, we discuss the consequences thereof for a 10 therapeutic manipulation of TRAIL in cancer and possible approaches to bypass these difficulties.

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Section: Accepted Articlementioning

confidence: 99%

The multifaceted role of TRAIL signaling in cancer and immunity

et al. 2020

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“…Its natural ligand, FasL (TNFSF6, CD95L) is a type Transplant Immunology xxx (2016) xxx-xxx II membrane protein belonging to the TNF family [7,8]. Fas is mainly expressed on tubular cells and may be up-regulated in AR or with injury such as cold ischemia [9,10], while FasL is expressed by graft infiltrating T cells and it has been reported to be a specific graft rejection marker [11].…”

Section: Introductionmentioning

confidence: 99%

Fas/Fas Ligand pathways gene polymorphisms in pediatric renal allograft rejection

Fadel

Elshamaa

Salah

et al. 2016

Transplant Immunology

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“…NK cells also kill tumor and virus-infected cells by apoptosis, mediating through TNF-related apoptosis-inducing ligand (TRAIL) and FasL [11]. …”

Section: Introductionmentioning

confidence: 99%

Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense

Lee

Lin

2013

Clinical and Developmental Immunology

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Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and their clinical implications.

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Down regulation of TRAIL and FasL on NK cells by Cyclosporin A in renal transplantation patients

Cited by 12 publications

References 28 publications

The multifaceted role of TRAIL signaling in cancer and immunity

The multifaceted role of TRAIL signaling in cancer and immunity

Fas/Fas Ligand pathways gene polymorphisms in pediatric renal allograft rejection

Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense

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