Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer

Kasajima, Atsuko; Sers, Christine; Sasano, Hironobu; Jöhrens, Korinna; Stenzinger, Albrecht; Noske, Aurelia; Buckendahl, Ann Christin; Darb‐Esfahani, Silvia; Müller, Berit; Budczies, Jan; Lehman, Annika; Dietel, Manfred; Denkert, Carsten; Weichert, Wilko

doi:10.1016/j.humpath.2010.05.014

Cited by 63 publications

(58 citation statements)

References 47 publications

(67 reference statements)

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“…Previously, MHC-I expression analysis has been performed based on tissue microarrays, precluding topographic marker expression analysis. 1,2,6 On the basis of these data, MHC-I protein expression has been suggested as a prognostic biomarker by several study groups. 1,2 Our data indicate that MHC expression in the main tumor body shows moderate heterogeneity, supporting TMA-based protein expression analysis.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 However, tumor cells can escape immune recognition through loss or alteration of MHC-I molecules on the cell surface leading to reduced immunogenicity and the generation of immune escape variants in CRC. 6 A common mechanism for MHC loss is genetic alteration in the antigen presentation pathway such as inactivation of b2-microglobulin and downregulation of transporters associated with antigen presentation (TAP). 7 This has frequently been observed in CRCs following the chromosomal and microsatellite instability pathway.…”

Section: Introductionmentioning

confidence: 99%

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Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome

Koelzer

Dawson

Andersson

et al. 2015

Translational Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome

Koelzer

Dawson

Andersson

et al. 2015

Translational Research

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“…Increased density of CD8 (+) TIL was predominantly found in TAP1, TAP2 and MHC class I antigen-positive cases. Down-regulation of the antigen processing machinery would cause a loss of inflammatory response in colorectal cancer (Kasajima et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Seeking colorectal carcinoma related genes based on regulation network

Yang¹

2011

Afr. J. Pharm. Pharmacol.

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Colorectal carcinoma (CRC) is one of the most frequent cancers worldwide with very high mortality. In this study, the microarray data was used to construct a regulation network to identify potential genes related with CRC. The results showed SP1, RELA, STAT1, PPARA and TP53 arise as hub nodes in transcriptome network in accordance with previous studies, and new transcription factors and target genes related with CRC were also identified, such as HIF1A and NFIC both regulated the PFKFB3 in response to CRC. In general, it is demonstrated that transcriptome network analysis is useful in identification of CRC related genes.

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“…They found TAP1 and TAP2 expression to be significantly associated with MHC class I antigen expression (P<0.001). Increased density of CD8 (+) TIL was predominantly found in TAP1, TAP2 and MHC class I antigenpositive cases, and tumors with CD8+ lymphocytic infiltration had an improved prognosis [22].…”

Section: Kasajima Et Al Explored the In Vivo Association Of Tap And mentioning

confidence: 96%

Why Don’t Immune Checkpoint Inhibitors Work in Colorectal Cancer?

Shi¹,

Zou²,

Kerr³

2017

J Gastrointest Cancer Stromal Tumor

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In recent years, immune checkpoint inhibitors have been shown to be effective in treating manifold types of cancer but less robust in colorectal cancer (CRC). While, the subgroup of CRC with microsatellite instability (MSI; also termed as mismatch repair deficient) showed a moderate response to Pembrolizumab in a single arm phase II clinical trial, microsatellite stable (MSS) cancers were unresponsive. Possible mechanisms that affect immune response in colorectal cancer will be reviewed in this article. We will also propose that histone deacetylase (HDAC) inhibition may reverse the immune editing commonly seen in advanced CRC and render them sensitive to immune checkpoint blockade.

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Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer

Cited by 63 publications

References 47 publications

Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome

Active immunosurveillance in the tumor microenvironment of colorectal cancer is associated with low frequency tumor budding and improved outcome

Seeking colorectal carcinoma related genes based on regulation network

Why Don’t Immune Checkpoint Inhibitors Work in Colorectal Cancer?

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