Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells

Chen, Yu Lin; Kan, Wai Ming

doi:10.1016/j.bbamcr.2015.07.025

Cited by 13 publications

(10 citation statements)

References 63 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results in tables (4) and (5) showed that there was a significant increase (p<0.05) in superoxide dismutase activity in CSF of acute lymphoblastic leukemia patients in both sexes and for all age group, our result was in agreement with previous studies which showed a significant increase in SOD activity In serum for patients with Chronic myeloid leukemia (CML) [50] and acute myeloid leukemia (AML) [51] and in CSF of children with neurocysticercosis [52] . The most efficient enzymatic antioxidants is superoxide dismutase (SOD), SOD activity protects cells from free radicals induced injury by catalyzing the dismutation of O -to O and to the less-reactive species hydrogen peroxide (H 2 O 2 ) [53] .…”

Section: Superoxide Dismutase (Sod)supporting

confidence: 82%

Studying the Enzymes Levels in Cerebrospinal Fluid for Children With Acute Lymphoblastic Leukemia

Bdaiwi¹

2017

WJPPS

View full text Add to dashboard Cite

The research includes studying of enzymes levels in the cerebrospinal fluid (CSF) for children with acute lymphoblastic leukemia (ALL) by determination of (9) parameter which include biochemical parameters: (73) were healthy children as control group which include (39) male and (34) female the age of children with acute lymphoblastic leukemia ranged from 1-15 year for both sex. The results showed there was a significant decrease in the activity of AChE, PChE and a significant increase in MAOA, AST, ALT, ALP, CK, LDH and SOD in CSF for children with acute lymphoblastic leukemia patients compared with control group for both sexes and these were a very good biochemical indicators for the patient body biochemical functions. The blood brain barrier loss its function in maintaining brain homoeostasis because of the oxidative stress and the age group (11-15)y of male had higher oxidative stress.

show abstract

Section: Superoxide Dismutase (Sod)supporting

confidence: 82%

Studying the Enzymes Levels in Cerebrospinal Fluid for Children With Acute Lymphoblastic Leukemia

Bdaiwi¹

2017

WJPPS

View full text Add to dashboard Cite

show abstract

“…The knockdown of SOD1 in nasopharyngeal carcinoma cells reduced its growth and induced apoptosis [25]. SOD1 regulates cell death and differentiation in myeloid leukemia cell lines K562, MEG-01, TF-1, and HEL [44]. Additionally, the inhibition or silencing of SOD1 increased the cell death induced by PMA (phorbol 12-myristate 13-acetate).…”

Section: Discussionmentioning

confidence: 99%

Effect of Kaempferol and Its Glycoside Derivatives on Antioxidant Status of HL-60 Cells Treated with Etoposide

et al. 2022

View full text Add to dashboard Cite

Kaempferol is a well-known antioxidant found in many plants and plant-based foods. In plants, kaempferol is present mainly in the form of glycoside derivatives. In this work, we focused on determining the effect of kaempferol and its glycoside derivatives on the expression level of genes related to the reduction of oxidative stress—NFE2L2, NQO1, SOD1, SOD2, and HO-1; the enzymatic activity of superoxide dismutases; and the level of glutathione. We used HL-60 acute promyelocytic leukemia cells, which were incubated with the anticancer drug etoposide and kaempferol or one of its three glycoside derivatives isolated from the aerial parts of Lens culinaris Medik.—kaempferol 3-O-[(6-O-E-caffeoyl)-β-d-glucopyranosyl-(1→2)]-β-d-galactopyranoside-7-O-β-d-glucuropyranoside (P2), kaempferol 3-O-[(6-O-E-p-coumaroyl)-β-d-glucopyranosyl-(1→2)]-β-d-galactopyranoside-7-O-β-d-glucuropyranoside (P5), and kaempferol 3-O-[(6-O-E-feruloyl)-β-d-glucopyranosyl-(1→2)]-β-d-galactopyranoside-7-O-β-d-glucuropyranoside (P7). We showed that none of the tested compounds affected NFE2L2 gene expression. Co-incubation with etoposide (1 µM) and kaempferol (10 and 50 µg/mL) leads to an increase in the expression of the HO-1 (9.49 and 9.33-fold at 10 µg/mL and 50 µg/mL, respectively), SOD1 (1.68-fold at 10 µg/mL), SOD2 (1.72-fold at 10–50 µg/mL), and NQO1 (1.84-fold at 50 µg/mL) genes in comparison to cells treated only with etoposide. The effect of kaempferol derivatives on gene expression differs depending on the derivative. All tested polyphenols increased the SOD activity in cells co-incubated with etoposide. We observed that the co-incubation of HL-60 cells with etoposide and kaempferol or derivative P7 increases the level of total glutathione in these cells. Taken together, our observations suggest that the antioxidant activity of kaempferol is related to the activation of antioxidant genes and proteins. Moreover, we observed that glycoside derivatives can have a different effect on the antioxidant cellular systems than kaempferol.

show abstract

“…This suggests that the catalase-dependent reduction of mitochondrial ROS controls immune cell proliferation. Similarly, the inhibition of the free radical scavenger Cu, Zn superoxide dismutase (SOD1), which is co-imported into mammalian peroxisomes with a copper chaperone [46], led to cell proliferation arrest and the promotion of cell death in myeloid leukemia cells [47]. Nevertheless, SOD1 is mainly cytosolic and just 0.15% localized inside the peroxisome [46] and there is no evidence for a specific role of peroxisomal SOD1 in this pathology.…”

Section: The Regulation Of Peroxisomal Genes Is Correlated To Prolmentioning

confidence: 99%

Peroxisomes in Immune Response and Inflammation

Cara

Andreoletti

Trompier

et al. 2019

IJMS

View full text Add to dashboard Cite

The immune response is essential to protect organisms from infection and an altered self. An organism’s overall metabolic status is now recognized as an important and long-overlooked mediator of immunity and has spurred new explorations of immune-related metabolic abnormalities. Peroxisomes are essential metabolic organelles with a central role in the synthesis and turnover of complex lipids and reactive species. Peroxisomes have recently been identified as pivotal regulators of immune functions and inflammation in the development and during infection, defining a new branch of immunometabolism. This review summarizes the current evidence that has helped to identify peroxisomes as central regulators of immunity and highlights the peroxisomal proteins and metabolites that have acquired relevance in human pathologies for their link to the development of inflammation, neuropathies, aging and cancer. This review then describes how peroxisomes govern immune signaling strategies such as phagocytosis and cytokine production and their relevance in fighting bacterial and viral infections. The mechanisms by which peroxisomes either control the activation of the immune response or trigger cellular metabolic changes that activate and resolve immune responses are also described.

show abstract

Down-regulation of superoxide dismutase 1 by PMA is involved in cell fate determination and mediated via protein kinase D2 in myeloid leukemia cells

Cited by 13 publications

References 63 publications

Studying the Enzymes Levels in Cerebrospinal Fluid for Children With Acute Lymphoblastic Leukemia

Studying the Enzymes Levels in Cerebrospinal Fluid for Children With Acute Lymphoblastic Leukemia

Effect of Kaempferol and Its Glycoside Derivatives on Antioxidant Status of HL-60 Cells Treated with Etoposide

Peroxisomes in Immune Response and Inflammation

Contact Info

Product

Resources

About