Down-regulation of p57Kip2 Induces Prostate Cancer in the Mouse

Abstract

p57Kip2 has been considered a candidate tumor suppressor

Chemopreventive Potential of an Ethyl Acetate Fraction from Curcuma Longa is Associated with Upregulation of p57kip2and Rad9 in the PC-3M Prostate Cancer Cell Line

“…It is also involved in glucocorticoid-induced anti-proliferation (Samuelsson et al, 1999). Recently, it has been shown that over-expression of p57 kip2 in prostate cancer cells significantly suppressed the cell proliferation and arrested the cell cycle at GO-G1 stage (Jin et al, 2008). Studies are in progress to see whether similar mechanisms are operative during PC-3M cell exposure to ethyl acetate fraction.…”

“…P57 kip2 has been considered a candidate tumor suppressor gene due to its location in the genome, biochemical activities, and imprinting status (Jin et al, 2008). Previously, many studies have focused on p21 CIP1/WAF1 or p27 kip1 whereas little is known about the biological function of p57 kip2 during tumorigenesis and cancer progression (Jin et al, 2008).…”

“…P57 kip2 has been considered a candidate tumor suppressor gene due to its location in the genome, biochemical activities, and imprinting status (Jin et al, 2008). Previously, many studies have focused on p21 CIP1/WAF1 or p27 kip1 whereas little is known about the biological function of p57 kip2 during tumorigenesis and cancer progression (Jin et al, 2008). Recently, it has been shown that the expression of p57 kip2 is significantly decreased in human prostate cancer (Jin et al, 2008) and the over-expression of p57 kip2 in prostate cancer cells significantly suppressed cell proliferation and reduced invasive ability (Jin et al, 2008).…”

“…Previously, many studies have focused on p21 CIP1/WAF1 or p27 kip1 whereas little is known about the biological function of p57 kip2 during tumorigenesis and cancer progression (Jin et al, 2008). Recently, it has been shown that the expression of p57 kip2 is significantly decreased in human prostate cancer (Jin et al, 2008) and the over-expression of p57 kip2 in prostate cancer cells significantly suppressed cell proliferation and reduced invasive ability (Jin et al, 2008). Further, in LNCaP cells, over-expression of p57 kip2 inhibited tumor formation in nude mice and the prostate of p57 kip2 knockout mice developed prostatic intraepithelial neoplasia and adenocarcinoma suggesting that p57 kip2 is an important gene in prostate cancer tumorigenesis, and the p57 kip2 pathway may be a potential target for prostate cancer prevention and therapy, more specifically, during turmeric chemoprevention (Jin et al, 2004(Jin et al, : 2008Williams et al, 2005).…”

“…Recently, it has been shown that the expression of p57 kip2 is significantly decreased in human prostate cancer (Jin et al, 2008) and the over-expression of p57 kip2 in prostate cancer cells significantly suppressed cell proliferation and reduced invasive ability (Jin et al, 2008). Further, in LNCaP cells, over-expression of p57 kip2 inhibited tumor formation in nude mice and the prostate of p57 kip2 knockout mice developed prostatic intraepithelial neoplasia and adenocarcinoma suggesting that p57 kip2 is an important gene in prostate cancer tumorigenesis, and the p57 kip2 pathway may be a potential target for prostate cancer prevention and therapy, more specifically, during turmeric chemoprevention (Jin et al, 2004(Jin et al, : 2008Williams et al, 2005). The Rad9 gene has many functions that could bear on carcinogenesis, including a role in maintaining genome integrity and regulating cell cycle checkpoints (Lieberman et al, 1996;Bessho & Sancar, 2000;Komatsu et al, 2000;Hopkins et al, 2004;Aiping et al, 2008).…”