Down‐regulation of p27<sup>Kip1</sup> expression is correlated with increased cell proliferation but not expression of p21<sup>waf1</sup> and p53, and human papillomavirus infection in benign and malignant tumours of sinonasal regions

Saegusa, Makoto; Nitta, Hisashi; Hashimura, Miki; Okayasu, Isao

doi:10.1046/j.1365-2559.1999.00688.x

Cited by 35 publications

(34 citation statements)

References 23 publications

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“…Keleş et al [18] found that p21 expression was not associated with dysplasia and the degree of dysplasia in IP in their study. There was no significant correlation with tumor differentiation in spite of increased p21 expression in paranasal sinus SCCs that Saegusa et al [35] observed. Similarly, we found no significant difference in the level of p21 expression between IPs and paranasal SCCs.…”

Section: Discussionmentioning

confidence: 71%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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Section: Discussionmentioning

confidence: 71%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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“…The loss of p27 expression has been correlated with a high degree of malignancy in many human cancers. Saegusa et al [32] demonstrated that the average p27 scores were inferior to normal levels in malignant lesions. In contrast to this study, Oncel et al [31] did not find significant differences between p27 expression in SNIPs and sinonasal SCC.…”

Section: Hpvmentioning

confidence: 99%

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Gioacchini

Bajraktari

et al. 2017

Eur Arch Otorhinolaryngol

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Schneiderian papillomas are uncommon tumors which may develop within the nasal cavity and comprise three well-defined histological types: sinonasal inverted papilloma (SNIP), exophytic papilloma, and oncocytic papilloma. It is well known the rate of Schneiderian papilloma may also present a malignant degeneration and SNIP represents the most important subgroup in consideration of its frequency and malignant propensity. Although HPV infection is always considered the first event favoring the development of SNIP, however, it is not established as an eventual connection between viral actions and malignant transformation. In fact, different molecular mechanisms are suspected to play a crucial role in this process and, currently, many authors agree that only by improving our knowledge about these mechanisms it will be possible to achieve new and effective targeted therapies. So the aim of this study was firstly to systematically review the literature focusing on different biomarkers that could be implicated in the stages of SNIP malignant degeneration. Secondly, a systematic review with meta-analysis was performed to better define the incidence of sinonasal malignancies originating from Schneiderian papilloma (SNIP, exophytic papilloma, and oncocytic papilloma). Twenty-nine studies comprising a total of 3177 patients were statistically analyzed. Results showed a 9% (95% CI = 7-11) overall rate of malignant transformation from Schneiderian papilloma. In conclusion, this analysis confirmed that the potential malignancy of Schneiderian papilloma should not be underestimated. On the other hand, our review showed the paucity of studies investigating the molecular alterations which may be related with the malignant transformation of SNIP.

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“…Saegusa et al identified weak to strong p27 immunoreactivity in inverted and exophytic papillomas. The author demonstrates that the loss of the p27 expression correlates with the increase of cell proliferation in sinonasal tumors (51) of action of HPV in oncogenesis have been attributed to its ability to render the p53 tumor suppressor gene of the host cell ineffective. The mutation of the p53 gene is currently the most commonly identified gene mutation in human neoplasia (52).…”

Section: Cytogenetics and Molecular Geneticsmentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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Down‐regulation of p27^Kip1 expression is correlated with increased cell proliferation but not expression of p21^waf1 and p53, and human papillomavirus infection in benign and malignant tumours of sinonasal regions

Cited by 35 publications

References 23 publications

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

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Down‐regulation of p27Kip1 expression is correlated with increased cell proliferation but not expression of p21waf1 and p53, and human papillomavirus infection in benign and malignant tumours of sinonasal regions

Cited by 35 publications

References 23 publications

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Malignant transformation of sinonasal inverted papilloma and related genetic alterations: a systematic review

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

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Product

Resources

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Down‐regulation of p27^Kip1 expression is correlated with increased cell proliferation but not expression of p21^waf1 and p53, and human papillomavirus infection in benign and malignant tumours of sinonasal regions