Down-regulation of NF-κB signals is involved in loss of 1α,25-dihydroxyvitamin D3 responsiveness

Bao, Bo‐Ying; Ting, Huei-Ju; Hsu, Jong-Wei; Yasmin-Karim, Sayeda; Messing, Edward M.; Lee, Yi-Fen

doi:10.1016/j.jsbmb.2010.02.030

Cited by 13 publications

(13 citation statements)

References 80 publications

(95 reference statements)

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“…Likewise, a similar effect was observed by other authors on colorectal cancer cells (Schwab et al, 2007) and prostate cancer cells (Krishnan & Feldman, 2010). Nevertheless, as opposing results have been also reported on the effects of Vit D on NF-kB expression levels (Bao et al, 2010;Janjetovic et al, 2011;Krishnan et al, 2007) further studies may better define the role of NF-kB in autophagy and, consequently, the potential therapeutic impact of Vit D in modulating this phenomenon in cancer cells.…”

Section: Vit D and Autophagysupporting

confidence: 77%

“…This phenomenon may results in an inhibition of IFN-g induced activation and potentiation of lysosomal activity of macrophages, recruitment of autophagic proteins, and, ultimately, may lead to a decrease of autophagy Wu and Sun (2011) NF-kB expression (?) Bao et al (2010), Krishnan and Feldman (2010), Tse et al (2010), andJanjetovic et al (2011) Induced expression of thioredoxin reductase 1 (TXNRD1) Swami et al (2003), Peehl et al (2004), Kovalenko et al (2010) Antioxidant defense and DNA repair Increased production of superoxide dismutase 1 and 2 (SOD1 and SOD2) in prostate epithelial cells (PECs) and in androgen-sensitive prostate cancer cells (LNCaP) Peehl et al (2004) and Lambert et al (2006) Increase of glucose-6-phosphate dehydrogenase (G6PDH) expression levels Zhang et al (2005), Bao et al (2008), and Kovalenko et al (2010) Induction of nuclear factor erythroid-derived 2-like 2 (NFE2L2) transcription factor that controls the gene expression of several enzymes of the antioxidants systems such as glutathione peroxidase (GPX) 3, heme oxygenase 1 (HMOX-1), and aldo-keto reductase 1C2(AKR1C2)…”

Section: Ink4dmentioning

confidence: 99%

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Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclusion: Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.

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Section: Vit D and Autophagysupporting

confidence: 77%

Section: Ink4dmentioning

confidence: 99%

Vitamin D in cancer chemoprevention

Giammanco¹,

Majo²,

Guardia

et al. 2015

Pharmaceutical Biology

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“…9 The VDR activation and signaling in immune cells were shown to result in the antiproliferative, prodifferentiation, and immunomodulatory effects. Vitamin D3 has suppressive effects on NF-kB signaling pathways in T cells, monocytes, and macrophages, 10 but not in B cells. Similarly, the transcription of many other regulatory factors by 1,25(OH) 2 D3 has been evaluated.…”

Section: Vitamin D3 and Immune Cellsmentioning

confidence: 97%

“…RevIew aRtIcle 10.5005/jp-journals-10054-0043 precursor 25 hydroxy cholecalciferol. Only recently, its crucial role as a potential immune modulator has been recognized.…”

Section: Ijmbmentioning

confidence: 99%

Role of Active Vitamin D3 in Immunity

Singh¹,

Verma²,

Singh³

et al. 2017

Indian Journal of Medical Biochemistry

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precursor 25 hydroxy cholecalciferol. Only recently, its crucial role as a potential immune modulator has been recognized. Clear identification of its well-documented roles in immune response and autoimmunity has led it to being actively pursued as a potential therapeutic agent. 1,2 Vitamin D3 influences all the key cells of the immune system and produces intracrine and paracrine effects on them. Most immune cells have the enzyme system to produce the active form of vitamin D3. It is an inhibitor of differentiation and maturation of dendritic cells (DCs) and decreases their antigen-presenting activity. It acts directly on T cells and alters the profile of their proliferation and differentiation. It promotes anti-inflammatory environment by inhibiting the Th1 and Th17 cells and promoting the Th 2 and T reg cell differentiations. Vitamin D3 induces antimicrobial effects in monocytes/macrophages by enhancing their phagocyte activity as well as helping the synthesis of antimicrobial peptides. Sunlight-mediated epidermal expression of 1,25(OH) 2 D3 acts as the link between the environment and immune system. It induces suppression of cutaneous immune response through the T-regulatory cells. Overall, it is considered an important regulator of both innate and adaptive immune systems. There is an emerging view that the vitamin D deficiency, which is widely prevalent these days, could have an important role in immune disorders, especially the autoimmune diseases. 2In this review, we present an overview of the current knowledge on vitamin D as an immunomodulator with the underlying molecular mechanisms and its possible role in immunological response with future implications. VITAMIN D-THE MOLECULEErgocalciferol, vitamin D2, and cholecalciferol, vitamin D3, are the two major forms of vitamin D. Vitamin D2 is synthesized by plants and fungi, while vitamin D3 is produced in large quantities in humans by photosynthesis in the skin. The ultraviolet (UV) light falling on the skin catalyzes the conversion of 7-dehydro-cholesterol into the previtamin D, which then spontaneously ABSTRACT Introduction:The active vitamin D3-1,25 dihydroxy cholecalciferol-is the key player in calcium and phosphorus metabolism and skeletal growth and functions. However, recent new developments have revealed its role in other tissues as well, referred to as the nonclassical actions of vitamin D. Not only the endocrinal effects, evidence indicates that vitamin D3 also has autocrine and paracrine functions due to its extrarenal synthesis by many cells, including the immune cells. All cells of the immune system have vitamin D receptors and show wide-ranging effects to it. It impacts both the innate and adaptive immune systems and the overall influence points to anti-infective, anti-inflammatory, immunosuppressive, and regulatory roles. It shows a significant role in chronic inflammatory and autoimmune diseases as well in susceptibility to infections.In this review, newer developments on the role of vitamin D in immunity and the underlying mechanism are d...

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“…These proteins have potent antiproliferative, pro-differentiative, and immunomodulatory effects [43]. Active Vitamin D inhibits several intracellular pathways such as the nuclear factor-κB (NF-κB) signaling pathway, X-box binding protein 1 (XBP1) and endoplasmic reticulum to nucleus signaling 1 (ERN1).…”

Section: Vitamin D Expression On Immune Systemmentioning

confidence: 99%