Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650

Li, Feng; Xie, Yun; Zhang, Hao; Wu, Yun

doi:10.1016/j.bbrc.2011.02.081

Cited by 64 publications

(70 citation statements)

References 17 publications

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“…Inhibitor of Growth 4 (ING4) is a tumor suppressor and a target of miR-650 both in gastric cancer and hepatocellular carcinoma (Zhang et al, 2010;Zeng et al, 2013) . N-myc downstream-regulated gene 2 (NDRG2) is also a direct target of miR-650 in colorectal cancer cells (Feng et al, 2011).…”

Section: Mir-650mentioning

confidence: 99%

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

Farooqı

Qureshi²,

Çoşkunpınar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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It is becoming progressively more understandable that between transcription and translation there lies another versatile regulator that quantitatively controls the expression of mRNAs. Identification of miRNAs as key regulators of wide ranging signaling cascades and modulators of different cell-type and context dependent activities attracted basic and clinical scientists to study modes and mechanisms in details. In line with this approach overwhelmingly increasing in vivo and in vitro studies are deepening our understanding regarding miR-421, mir-155 and miR-650 mediated regulation of cellular activities. We also attempt to provide an overview of long non coding RNAs.

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Section: Mir-650mentioning

confidence: 99%

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

Farooqı

Qureshi²,

Çoşkunpınar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…15 Previous studies from our group and others have demonstrated that NDRG2 is involved in cell differentiation, 17 proliferation, 18 apoptosis 19,20 and the stress response. 21 NDRG2 in particular has been proposed as a tumor suppressor 21 because mounting evidence demonstrates that NDRG2 is deregulated in various carcinomas, including glioblastoma, 15 breast cancer, 22 hepatocellular cancer 23 and colorectal cancer, 24 while upregulating NDRG2 could reverse the malignant phenotype of cancer cells. 21,25,26 Our most recent studies showed that NDRG2 expression levels were lower in PC tissues than in their benign counterparts, and forced expression of NDRG2 inhibited the proliferation and invasion of PC cells.…”

Section: Introductionmentioning

confidence: 99%

NDRG2 acts as a negative regulator downstream of androgen receptor and inhibits the growth of androgen-dependent and castration-resistant prostate cancer

Chen

et al. 2015

Cancer Biology & Therapy

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“…miR-650 was selected for further studies and its role was analyzed in the production of the inflammatory cytokine, IL6, in MG-63 osteosarcoma cells. miR-650 was selected for further functional studies, as its target genes, ING4 and NDRG2, are important in gastric and colorectal cancer cells, respectively (13,14). In addition, miR-650 has previously been identified as a CNV-miRNA in another study (10).…”

Section: Discussionmentioning

confidence: 99%

“…Among the 38 miRNAs, the target genes of three (miR-650, miR-132 and miR-212) have previously been reported (13,26). From those three miRNAs, miR-650 was selected for this functional study, as its location overlapped with the exon region of another transcript, and as its target genes have been identified in several cancer cell types, but not in osteosarcoma cells (14,16,17,20,27).…”

Section: Identification Of Mirnas In Cnv Regions and Selection Of Mirmentioning

confidence: 99%

“…miR-650 was identified from the human colorectal microRNAome (11), and its genomic association with the immunoglobulin (Ig) λ variable region gene was reported based on sequence comparisons and evolutionary approaches (12). Two studies have described the roles of miR-650 in gastrointestinal cancers such as gastric and colorectal cancer by regulating expression of its target genes, inhibitor of growth family member 4 (ING4) and N-myc downstream-regulated gene family member 2 (NDRG2), respectively (13,14). miR-650 is associated with several other tumors, including melanoma, lung adenocarcinoma, hepatocellular carcinoma and glioma (15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells

et al. 2015

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Abstract. Copy number variation is a well-known genetic variation. microRNAs (miRNAs/miRs) are non-coding RNAs that mediate gene expression by regulating target mRNAs. In the present study, copy number deletions encompassing miRNA coding regions were investigated to determine the association between the deletion of miRNA and its phenotypic effects. A total of 38 human miRNAs in copy number variants were identified and miR-650, which is functional in the human osteosarcoma MG-63 cell line, was selected. Overexpression of miR-650 decreased the expression of inhibitor of growth family member 4 (ING4) in the MG-63 cells and increased interleukin (IL)6 transcription, as well as IL6 secretion in IL1B-stimulated cells. Furthermore, miR-650 downregulated the amount of nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor α and increased the transcriptional activity of nuclear factor (NF)κB. Downregulation of ING4 also increased the production of IL6, similar to miR-650 overexpression. Taken together, these data indicate that miR-650 plays a significant role in the production of IL6 by regulating ING4 expression and NFκB signaling in IL1B-stimulated MG-63 osteosarcoma

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Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650

Cited by 64 publications

References 17 publications

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

miR-421, miR-155 and miR-650: Emerging Trends of Regulation of Cancer and Apoptosis

NDRG2 acts as a negative regulator downstream of androgen receptor and inhibits the growth of androgen-dependent and castration-resistant prostate cancer

MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells

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