Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation
Mengjun Geng,
Qiujing Shao,
Jiacheng Fu
et al.
Abstract:Chronic stress is the primary environmental risk factor for major depressive disorder (MDD), and there is compelling evidence that neuroinflammation is the major pathomechanism linking chronic stress to MDD. Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a negative regulator of MAPK signaling pathways involved in cellular stress responses, survival, and neuroinflammation. We examined the possible contributions of MKP-1 to stress-induced MDD by comparing depression-like behaviors (anhedonia, m… Show more
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