Down-regulation of miR-326 is associated with poor prognosis and promotes growth and metastasis by targeting FSCN1 in gastric cancer

Li, Yanliang; Gao, Yongsheng; Xu, Yue; Ma, Haiyan; Yang, Mei

doi:10.3109/08977194.2015.1076406

Cited by 44 publications

(55 citation statements)

References 25 publications

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“…miR-326 downregulation is correlated with clinical stage, tumour depth, lymph node metastasis and distant metastasis. Survival analysis indicated that miR-326 is a poor independent prognostic factor for patients with gastric cancer (36). In another study, miR-326 was decreased in osteosarcoma, and low miR-326 expression is associated with distant metastasis and advanced clinical stage.…”

Section: Discussionmentioning

confidence: 94%

“…Low miR-326 expression is strongly correlated with advanced pathological grade and low KPS score (35). Li et al reported that miR-326 is downregulated in gastric cancer and cell lines (36,37). miR-326 downregulation is correlated with clinical stage, tumour depth, lymph node metastasis and distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…In glioma, ectopic miR-326 expression suppresses cell proliferation, colony formation, invasion and metabolic activity, reduces ATP and glutathione levels, induces apoptosis, causes cell cycle arrest at the G1 phase and improves the chemosensitivity of cells to curcumin (33,34,39,40). In gastric cancer, miR-326 over expression represses cell growth, migration and invasion (36,37). In non-small cell lung cancer, the induced miR-326 expression attenuates cell proliferation, colony formation, migration, and invasion, reverses chemoresistance, enhances cell apoptosis in vitro and decreases tumour growth in vivo (20,(41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA-326 inhibits cell proliferation and invasion, activating apoptosis in hepatocellular carcinoma by directly targeting LIM and SH3 protein 1

Ran

Chen

et al. 2017

Oncology Reports

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Hepatocellular carcinoma (HCC) is the fifth-most common cancer and third leading cause of cancer-related deaths worldwide. Increasing evidence indicates that dysregulation of microRNAs is often observed in HCC, and has been extensively investigated in terms of cancer formation, progression, diagnosis, therapy, and prognosis. Recently, microRNA-326 (miR-326) has been demonstrated to play important roles in multiple types of human cancer. However, the expression pattern, clinical significance, roles and regulatory mechanisms of miR-326 in HCC have yet to be elucidated. In this study, miR-326 was frequently downregulated in HCC tissues and cell lines. Low miR-326 expression was significantly associated with the TNM stage, differentiation and lymph node metastasis of HCC patients. Further functional assays demonstrated that the recovered miR-326 expression inhibited HCC cell proliferation and invasion and activated cell apoptosis in vitro. In addition, LIM and SH3 protein 1 (LASP1) was identified as a direct target gene of miR-326 in HCC. Furthermore, LASP1 was upregulated in HCC tissues and cell lines. The expression level of LASP1 mRNA was inversely correlated with that of miR-326 in HCC tissues. Moreover, LASP1 silencing elicited effects similar to miR-326 overexpression on HCC cells, and LASP1 upregulation markedly reversed the effects of miR-326 overexpression on HCC cells. These results revealed that miR-326 suppressed the progression of HCC by directly targeting LASP1. Therefore, miR-326 may be used as a potential therapeutic target for the treatment of patients with HCC.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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MicroRNA-326 inhibits cell proliferation and invasion, activating apoptosis in hepatocellular carcinoma by directly targeting LIM and SH3 protein 1

Ran

Chen

et al. 2017

Oncology Reports

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“…Ji et al identified that miR-326 inhibited GC cell growth by downregulating NOB1 [20]. Li et al demonstrated that downregulation of miR-326 was associated with poor prognosis and promoted GC growth [21]. To further verify the relationship between hsa_circ_0000467 and miR-326-3p in GC, we performed rescue experiments using different groups of BGC-823 and SGC-7901 cells.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p

Jiang

Zhang

et al. 2020

BioMed Research International

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Circular RNAs are a class of endogenous noncoding RNAs that play an important role in gene regulation. These RNAs are involved in the development and progression of various cancers, but their roles in gastric cancer have not yet been thoroughly elucidated. This study showed that hsa_circ_0000467 expression was higher in gastric cancer tissues than in corresponding adjacent tissues (P<0.050) and that hsa_circ_0000467 expression levels were correlated with gastric cancer histological grade (P<0.050). In addition, hsa_circ_0000467 was remarkably upregulated in gastric cancer cell lines (P<0.001). Cell function experiments indicated that hsa_circ_0000467 downregulation decreased the proliferation and invasion ability of BGC-823 and SGC-7901 cells and the number of cells entering the G2/M phase. A direct binding interaction was detected between hsa_circ_0000467 and miR-326-3p by dual-luciferase reporter assays. In addition, the results showed that inhibition of miR-326-3p reversed the decreases in the proliferation and invasion of BGC-823 and SGC-7901 cells caused by hsa_circ_0000647 downregulation. Inhibition of miR-326-3p also decreased the number of cells entering the G2/M phase and the expression of cyclin D1. In conclusion, hsa_circ_0000467 plays a regulatory role in the development and progression of gastric cancer by regulating miR-326-3p, and this circRNA may be a potential diagnostic marker and therapeutic target of gastric cancer.

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“…Liang et al, 2010), prostate cancer (H. Kristensen et al, 2016), esophageal cancer (Hong et al, 2014), cutaneous T-cell lymphoma (CTCL; Ralfkiaer et al, 2011), gastric cancer (Y. Li, Gao, Xu, Ma, & Yang, 2015), pancreatic ductal adenocarcinoma (Z. L. , hepatocellular carcinoma (HCC; Hu, Ran, Chen, Zhang, & Xu, 2017), medulloblastoma (Ferretti et al, 2008), acute myelogenous leukemia (Koutova et al, 2015), and chronic myelogenous leukemia (CML; Babashah et al, 2013). miR-326 is also involved in the pathogenesis of idiopathic pulmonary fibrosis (Das et al, 2014), and HIV infection (Houzet et al, 2012).…”

Section: Mir-326 In Other Diseasesmentioning

confidence: 99%

The MicroRNA‐326: Autoimmune diseases, diagnostic biomarker, and therapeutic target

Jadideslam

Ansarin

Sakhinia

et al. 2018

Journal Cellular Physiology

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MicroRNAs (miRNAs) are uniquely regulated in healthy, inflamed, activated, cancerous, or other cells and tissues of a pathological state. Many studies confirm that immune dysregulation and autoimmune diseases with inflammation are correlated with various miRNA expression changes in targeted tissues and cells in innate or adaptive immunity. In this review, we will explain the history and classification of epigenetic changes. Next, we will describe the role of miRNAs changes, especially mir-326 in autoimmunity, autoinflammatory, and other pathological conditions. A systematic search of MEDLINE, Embase, and Cochrane Library was presented for all related studies from 1899 to 2017 with restrictions in the English language. In recent years, researchers have concentrated on mostly those roles of miRNA that are correlated with the inflammatory and anti-inflammatory process. Latest studies have proposed a fundamental pathogenic role in cancers and autoinflammatory diseases. Studies have described the role of microRNAs in autoimmunity and autoinflammatory diseases, cancers, and so on. The miRNA-326 expression plays a significant role in autoimmune and other types of diseases.

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Down-regulation of miR-326 is associated with poor prognosis and promotes growth and metastasis by targeting FSCN1 in gastric cancer

Abstract: Our study demonstrated that miR-326 overexpression was a poor prognostic marker for gastric cancer patients, and miR-326 served as a tumor suppressor in gastric cancer via directly regulating FSCN1.

Cited by 44 publications

References 25 publications

MicroRNA-326 inhibits cell proliferation and invasion, activating apoptosis in hepatocellular carcinoma by directly targeting LIM and SH3 protein 1

MicroRNA-326 inhibits cell proliferation and invasion, activating apoptosis in hepatocellular carcinoma by directly targeting LIM and SH3 protein 1

Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p

The MicroRNA‐326: Autoimmune diseases, diagnostic biomarker, and therapeutic target

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