2009
DOI: 10.1007/s12032-009-9269-x
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Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance

Abstract: MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of target mRNAs. Altered expression of specific miRNAs in several tumor types has been reported. However, the expression levels of miR-31 in gastric cancers are unclear. The objective of the present study was to compare the expression profile of miR-31 between gastric cancer tissues and non-tumor tissues. Real-time quantitative reverse transcription-polymerase chain reaction technology was used to detect the levels of miR-31 expression. The ex… Show more

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Cited by 95 publications
(62 citation statements)
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“…Controlling expression of Radixin, miR-31 causes anoikis-mediated cell death. In agreement with these data, miR-31 expression has been found to be attenuated in human breast [88][89][90], prostate [91], ovary [92], stomach [93,94] and bladder cancer [95]. Moreover miR-31 levels in primary human breast tumors were inversely associated with distant metastases [86].…”
Section: Mirnas and Metastasissupporting
confidence: 71%
“…Controlling expression of Radixin, miR-31 causes anoikis-mediated cell death. In agreement with these data, miR-31 expression has been found to be attenuated in human breast [88][89][90], prostate [91], ovary [92], stomach [93,94] and bladder cancer [95]. Moreover miR-31 levels in primary human breast tumors were inversely associated with distant metastases [86].…”
Section: Mirnas and Metastasissupporting
confidence: 71%
“…Association of miR-31 loss with the 9p21.3 lesion in cancer may have widespread clinical implications. Deletions that may potentially contain MIR31 have been recently reported in urothelial carcinomas (37), and down-regulation of this microRNA has been observed in gastric cancer (38). Also, 9p21.3 deletions were found in 31% of non-small lung cancers (39), ϳ85% of pancreatic adenocarcinomas (40), 35% of biliary tract tumors (41), 37.5% of osteosarcomas (42), 38% of soft tissue sarcomas (43), 75% of gliomas (44), 33-39% of T-cell acute lymphoblastic leukemias, 67% of primary cutaneous diffuse large B-cell lymphoma of the leg type (45), and ϳ17% of breast cancers (46).…”
Section: Discussionmentioning
confidence: 96%
“…For the detection of mature, single-stranded form of let-7a was performed using a miScript PCR system (Qiagen): miScript II RT Kit and miScript SYBR Green PCR Kit (26).…”
Section: Real-time Pcr Of Mirnasmentioning
confidence: 99%