Down-regulation of microRNA-146a is associated with high-risk human papillomavirus infection and epidermal growth factor receptor overexpression in penile squamous cell carcinoma

Peta, Elektra; Cappellesso, Rocco; Masi, Giulia; Sinigaglia, Alessandro; Trevisan, Marta; Grassi, Angela; Camillo, Barbara Di; Vassarotto, Elisa; Fassina, Ambrogio; Palù, Giorgio; Barzon, Luisa

doi:10.1016/j.humpath.2016.10.019

Cited by 36 publications

(31 citation statements)

References 25 publications

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“…Researchers analyzed miR‐146a expression in 59 penile squamous cell carcinomas and observed lower levels in high‐risk human papilloma virus (HPV)‐positive cancers compared to HPV‐negative. They also determined suppression of miR‐146a to be a mechanism contributing to EGFR overexpression in this cancer (Peta et al, ).…”

Section: Role Of Mir‐146a In Specific Cancersmentioning

confidence: 95%

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miR‐146a‐5p: Expression, regulation, and functions in cancer

2019

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Cancer as we know it is actually an umbrella term for over 100 very unique malignancies in various tissues throughout the human body. Each type, and even subtype of cancer, has different genetic, epigenetic, and other cellular events responsible for malignant development and metastasis. Recent work has indicated that microRNAs (miRNAs) play a major role in these processes, sometimes by promoting cancer growth and other times by suppressing tumorigenesis. miRNAs are small, noncoding RNAs that negatively regulate expression of specific target genes. This review goes into an in‐depth look at the most recent finding regarding the significance of one particular miRNA, miR‐146a‐5p, and its involvement in cancer. Target gene validation and pathway analysis have provided mechanistic insight into this miRNA's purpose in assorted tissues. Additionally, this review outlines novel findings that suggest miR‐146a‐5p may be useful as a noninvasive biomarker and as a targeted therapeutic in several cancers. This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs

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Section: Role Of Mir‐146a In Specific Cancersmentioning

confidence: 95%

“…Receptor activation leads to pro-growth and proliferation signaling Peta et al (2017), Kumaraswamy et al (2015), Ali et al (2014), Huang, He, Rong, Dang, and Chen (2014), Chen et al (2013), Xu et al (2012), Kogo et al (2011), Li et al (2010a, 2010b, Hurst et al (2009) NOTCH1/2 Endometrial, Esophageal, Glioblastoma…”

Section: Glioblastomamentioning

confidence: 99%

miR‐146a‐5p: Expression, regulation, and functions in cancer

2019

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“…Peta et al demonstrated that the expression level of miR‐146a is decreased in high‐risk HPV‐infected penile squamous cell carcinomas (SCCs) and in human foreskin keratinocytes (HFKs) transduced with the E6 oncogene of HPV‐16. They found a significant negative correlation between EGFR expression and miR‐146a‐5p levels in penile SCCs, and they showed that miR‐146a upregulation leads to suppress HeLa and HFKs cells proliferation . In another study by this group, miR‐146a‐5p was explored in HPV‐related cancer and observed that although the E6 proteins of HPV‐16 (high risk) suppresses the miR‐146a‐5p expression in primary oral keratinocytes and in HFKs, HPV6 E6 (low risk) does not have this function.…”

Section: Mir‐146a In Papillomavirusesmentioning

confidence: 99%

“…They found a significant negative correlation between EGFR expression and miR-146a-5p levels in penile SCCs, and they showed that miR-146a upregulation leads to suppress HeLa and HFKs cells proliferation. 65 In another study by this group, 66 miR-146a-5p was explored in HPV-related cancer and observed that although the E6 proteins of HPV-16 (high risk) suppresses the miR-146a-5p expression in primary oral keratinocytes and in HFKs, HPV6 E6 (low risk) does not have this function. Also, upregulation of miR-146a-5p in cervical carcinoma cell lines and HFKs leads to inhibit the capacity of migration and cell proliferation.…”

Section: Mir-146a In Papillomavirusesmentioning

confidence: 99%

The role of miR‐146a in viral infection

et al. 2019

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Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional regulation of cellular‐genes regulatory pathways. They also emerged as a significant regulator of the immune response. In particular, miR‐146a acts as an importance modulator of function and differentiation cells of the innate and adaptive immunity. It has been associated with disorder including cancer and viral infections. Given its significance in the regulation of key cellular processes, it is not surprising which virus infection have found ways to dysregulation of miRNAs. miR‐146a has been identified in exosomes (exosomal miR‐146a). After the exosomes release from donor cells, they are taken up by the recipient cell and probably the exosomal miR‐146a is able to modulate the antiviral response in the recipient cell and result in making them more susceptible to virus infection. In this review, we discuss recent reports regarding miR‐146a expression levels, target genes, function, and contributing role in the pathogenesis of the viral infection and provide a clue to develop the new therapeutic and preventive strategies for viral disease in the future.

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“…On the other hand, miR-146a expression is decreased in various cancers, such as NK/T cell lymphoma [ 15 ], gastric cancer [ 16 ], castration-resistant prostate cancer [ 17 ], head and neck squamous cell carcinoma [ 18 ], hepatocellular carcinoma [ 19 ], penile squamous cell carcinoma [ 20 ] and non-small cell lung cancer [ 21 ]. Enforced expression of miR-146a suppresses cell proliferation and invasion [15-19, 21-24) and angiogenesis via targeting EGFR [ 17 ], RAF6 [ 19 ], CCND1/2 [ 21 ], Notch1 [ 22 ] or Rac1 [ 24 ], induces cell apoptosis [ 15 , 16 , 23 ] and enhanced chemo-sensitivity [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3β/β-catenin signaling pathway

et al. 2017

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MicroRNA-146a-5p (miR-146a) functions as a tumor suppressor or oncogene involved in multiple biological processes. But, the underlying molecular mechanisms by which miR-146a contributes to osteosarcoma (OS) remain unclear. The correlation of miR-146a expression with clinicopathologic characteristics and prognosis of OS patients was analyzed by Kaplan-Meier and Cox regression analysis. Cell growth in vitro and in vivo was assessed by MTT, cell colony formation and animal models. The target of miR-146a was identified by bioinformatics software and gene luciferase reporter. As a result, miR-146a expression was substantially elevated in OS tissues and was positively associated with the tumor size (P=0.001) and recurrence (P=0.027) of OS patients. Moreover, knockdown of miR-146a suppressed cell proliferation and colony formation in vitro and in vivo. In addition, zinc and ring finger 3 (ZNRF3) was identified as a direct target of miR-146a in OS cells, and was negatively correlated with miR-146a expression in OS tissues. Overexpression of ZNRF3 inhibited cell growth and rescued the tumor-promoting role of miR-146a via inhibition of GSK-3β/β-catenin signaling pathway. Taken together, miR-146a may function as an oncogene in OS cells by targeting ZNRF3/GSK-3β/β-catenin signaling pathway, and represent a promising biomarker for OS patients.

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Down-regulation of microRNA-146a is associated with high-risk human papillomavirus infection and epidermal growth factor receptor overexpression in penile squamous cell carcinoma

Cited by 36 publications

References 25 publications

miR‐146a‐5p: Expression, regulation, and functions in cancer

miR‐146a‐5p: Expression, regulation, and functions in cancer

The role of miR‐146a in viral infection

miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3β/β-catenin signaling pathway

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