“…INPP5E plays multiple important roles at the cilium. Among others, these roles include regulation of: (i) ciliary phosphoinositide levels, (ii) ciliary protein composition, (iii) ciliary Hedgehog and PI3K signaling, (iv) ciliary ectovesicle release, (v) ciliary stability, and (vi) ciliogenesis ( Jacoby et al, 2009 ; Bielas et al, 2009 ; Guo et al, 2019 ; Garcia-Gonzalo et al, 2015 ; Chávez et al, 2015 ; Badgandi et al, 2017 ; Dyson et al, 2017 ; Phua et al, 2017 ; Wang et al, 2011 ; Hakim et al, 2016 ; Xu et al, 2016 ; Xu et al, 2017 ; Constable et al, 2020 ; Hasenpusch-Theil et al, 2020 ; Sharif et al, 2021 ; Ukhanov et al, 2022 ; Yue et al, 2021 ). Although most of its functions are ciliary, INPP5E also plays extraciliary roles, like promoting autophagosome-lysosome fusion during autophagy ( Hasegawa et al, 2016 ).…”