Down-Regulation of Endogenous Hydrogen Sulfide Pathway in Pulmonary Hypertension and Pulmonary Vascular Structural Remodeling Induced by High Pulmonary Blood Flow in Rats

Abstract

The endogenous H2S pathway is down-regulated in PH and pulmonary vascular structural remodeling is induced by high pulmonary blood flow.

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

“…H 2 S is a new emerging gaseous signaling molecule (15)(16)(17). H 2 S is normally present in humans and can be generated endogenously from L-Cys in a reaction catalyzed by either CBS or CSE.…”

“…Historically, H 2 S was known as a toxic gas, and mammalians have evolved a fine-tuned regulatory system to control H 2 S generation at the cellular level by catabolism of the gas through oxidation in mitochondria or by methylation followed by scavenging by metalloproteins and heme-containing compounds (18). The role of H 2 S in vascular homeostasis is a new concept, and in recent years data have accumulated suggesting a vasorelaxant role for H 2 S (15)(16)(17)19), and a possible cross-talk with the NO pathway has been proposed (20). H 2 S was recently shown to be a physiologic vasorelaxant in mice with deletion of CSE (19).…”

Genetic Aspects of the Vascular Type of Ehlers-Danlos Syndrome (vEDS, EDSIV) in Japan

“…10,11 Type III collagen is a homotrimer formed by an association of 3 alpha 1 (III) chains derived from 1 gene (COL3A1). The core of the molecule is a triplehelix region with an amino acid sequence characterized by (Gly(glycine)-X-Y)343 repeats.…”

Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy

“…20 All the stereological evaluations were conducted with assistance from the Motic Digital Medical Image Analysis System (Motic Med 6.0; Motic Image Technology Co, Ltd, Beijing, China). 15 A modified sulfide electrode (PXS-270 ionometer, Pag/ S1 Modified Sulfide Electrode; Shanghai Precision & Scientific Instrument Co, Ltd, Shanghai, China) was used for measurement of H2S. For the preparation of antioxidant and standard H2S solution, samples of plasma were obtained from fasting rats and combined with antioxidant solution of equal volume.…”