Down-Regulation of Donor Kupffer Cell B7 Expression Reduced Recipient Lymphocyte Activation and Secretion of Interleukin-2 In Vitro

Li, T.; Zhu, Jinmin; Wang, F.-S.; Leng, Xi-sheng

doi:10.1016/j.transproceed.2015.10.038

Cited by 5 publications

(3 citation statements)

References 18 publications

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“… 37 To further characterize the role of PD-L1 in the same study, Gong et al 37 cocultured KCs that were silenced by PD-L1-shRNA interference plasmids with T cells and observed significantly higher levels of inflammatory IL-2, IFN-γ, and TNF cytokines. 37 A separate in vitro study by Li et al 55 cocultured isolated donor LEW KCs, transfected for RNA interference vector of costimulatory B7 molecules, with donor BN lymphocytes and saw that decreased B7 expression prevented lymphocyte activation and proliferation, encouraging tolerance. 55 These results of coinhibitory and costimulatory molecule expression in rat macrophages reflect observations in human LT, once again demonstrating the rat model’s relevance and high resemblance to the human model.…”

Section: The Interconnection Between the Liver And The Bodymentioning

confidence: 99%

“… 37 A separate in vitro study by Li et al 55 cocultured isolated donor LEW KCs, transfected for RNA interference vector of costimulatory B7 molecules, with donor BN lymphocytes and saw that decreased B7 expression prevented lymphocyte activation and proliferation, encouraging tolerance. 55 These results of coinhibitory and costimulatory molecule expression in rat macrophages reflect observations in human LT, once again demonstrating the rat model’s relevance and high resemblance to the human model.…”

Section: The Interconnection Between the Liver And The Bodymentioning

confidence: 99%

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Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model

2021

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For many individuals with end-stage liver disease, the only treatment option is liver transplantation. However, liver transplant rejection is observed in 24%–80% of transplant patients and lifelong drug regimens that follow the transplant procedure lead to serious side effects. Furthermore, the pool of donor livers available for transplantation is far less than the demand. Well-characterized and physiologically relevant models of liver transplantation are crucial to a deeper understanding of the cellular processes governing the outcomes of liver transplantation and serve as a platform for testing new therapeutic strategies to enhance graft acceptance. Such a model has been found in the rat transplant model, which has an advantageous size for surgical procedures, similar postoperative immunological progression, and high genome match to the human liver. From rat liver transplant studies published in the last 5 years, it is clear that the rat model serves as a strong platform to elucidate transplant immunological mechanisms. Using the model, we have begun to uncover potential players and possible therapeutic targets to restore liver tolerance and preserve host immunocompetence. Here, we present an overview of recent literature for rat liver transplant models, with an aim to highlight the value of the models and to provide future perspectives on how these models could be further characterized to enhance the overall value of rat models to the field of liver transplantation.

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Section: The Interconnection Between the Liver And The Bodymentioning

confidence: 99%

Section: The Interconnection Between the Liver And The Bodymentioning

confidence: 99%

Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model

2021

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“…After liver transplantation, the reduction of B7 expression in donor KCs could suppress the activation of recipient T lymphocytes and secretion of IL-2 via the CD28/B7 costimulatory pathway and may induce immune tolerance [164]. The cytokines TNF-α expression in KCs is a marker of activated KCs after transplantation and it may be a good target for reversing acute rejection post transplantation [165].…”

Section: Kupffer Cells In Liver Transplantation Immunologymentioning

confidence: 99%

The Biological Function of Kupffer Cells in Liver Disease

Ma¹,

Yang²,

He³

et al. 2017

Biology of Myelomonocytic Cells

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Kupffer cells, which have a characteristic morphology and a kind of phenotype, are the resident macrophages in liver, serve as the largest population mononuclear phagocytes in the body, and are localized in the periportal zone. They have phagocytosis capacity and release all kinds of cytokines, chemokines, and soluble biological mediators. Owing to the different functions of Kupffer cells, they play an important role in liver diseases. In this chapter, we review the role of Kupffer cells in infectious disease, fatty liver disease, liver fibrosis, liver ischemia-reperfusion injury, liver transplantation immunology, as well as liver cancer and metastases.

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