Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

Abusnina, Abdurazzag; Alhosin, Mahmoud; Keravis, Thérèse; Muller, Christian D.; Fuhrmann, Gregor; Bronner, Christian; Lugnier, Claire

doi:10.1016/j.cellsig.2010.08.015

Cited by 71 publications

(43 citation statements)

References 41 publications

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“…Recently, it has been shown that TQ-encapsulated nanoparticles induce apoptosis in cancer cells by increasing the expression of miR-34a through p53-dependent pathway [84]. TQ, the most abundant biologically active component of black cumin oil, has potent anticancer activities on many human cancer cell lines by targeting numerous signalling pathways involved in the regulation of cell cycle and apoptosis including p53 and p73 pathways [29, 63, 85]. Considering that TQ targets UHRF1 in p53-mutated Jurkat cells through p73-dependent pathway [63] and that UHRF1 is also regulated by p53 [62], we might imagine that TQ decreases the expression of UHRF1 in cancer cells through the upregulation of miR-34a.…”

Section: Signalling Pathways Involved In Uhrf1 Regulation In Cancer Cmentioning

confidence: 99%

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Alhosin

Omran

Zamzami

et al. 2016

J Exp Clin Cancer Res

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Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and histone changes is a main hallmark of cancer. Ubiquitin-like with PHD and RING Finger domains 1 (UHRF1) is a potent oncogene overexpressed in various solid and haematological tumors and its high expression levels are associated with decreased expression of several TSGs including p16 INK4A, BRCA1, PPARG and KiSS1. Using its several functional domains, UHRF1 creates a strong coordinated dialogue between DNA methylation and histone post-translation modification changes causing the epigenetic silencing of TSGs which allows cancer cells to escape apoptosis. To ensure the silencing of TSGs during cell division, UHRF1 recruits several enzymes including histone deacetylase 1 (HDAC1), DNA methyltransferase 1 (DNMT1) and histone lysine methyltransferases G9a and Suv39H1 to the right place at the right moment. Several in vitro and in vivo works have reported the direct implication of the epigenetic player UHRF1 in tumorigenesis through the repression of TSGs expression and suggested UHRF1 as a promising target for cancer treatment. This review describes the molecular mechanisms underlying UHRF1 regulation in cancer and discusses its importance as a therapeutic target to induce the reactivation of TSGs and subsequent apoptosis.

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Section: Signalling Pathways Involved In Uhrf1 Regulation In Cancer Cmentioning

confidence: 99%

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Alhosin

Omran

Zamzami

et al. 2016

J Exp Clin Cancer Res

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“…Indeed, UHRF1 was reported up-regulated in various human cancers [12]. Knockdown of UHRF1 expression in cancer cells significantly suppressed cell growth, indicating that UHRF1 was essential for progression of cancers [13]. Collectively, UHRF1 may serve as an attractive biomarker and therapeutic target for cancer treatment [3,14,15].…”

Section: Introductionmentioning

confidence: 97%

Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma

Peng

et al. 2015

Biochemical and Biophysical Research Communications

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“…More recently, Paramasivam and collaborators [78] showed that thymoquinone produced cytotoxic effects on Neuro-2a mouse neuroblastoma cells through caspase 3 activation, with downregulation of XIAP. Abusnina and collaborators [79] demonstrated that thymoquinone induces acute lymphoblastic leukemia cell apoptosis. Thymoquinone also has potential as a novel therapeutic agent against pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Monoterpenes Found in Essential Oils

Sobral

Xavier

Lima

et al. 2014

The Scientific World Journal

213

142

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Cancer is a complex genetic disease that is a major public health problem worldwide, accounting for about 7 million deaths each year. Many anticancer drugs currently used clinically have been isolated from plant species or are based on such substances. Accumulating data has revealed anticancer activity in plant-derived monoterpenes. In this review the antitumor activity of 37 monoterpenes found in essential oils is discussed. Chemical structures, experimental models, and mechanisms of action for bioactive substances are presented.

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Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

Cited by 71 publications

References 41 publications

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer

Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma

Antitumor Activity of Monoterpenes Found in Essential Oils

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