Down-regulation of CIT can inhibit the growth of human bladder cancer cells

Liu, Zan; Yan, Haiyan; Yang, Yang; Wei, Lixiang; Xia, Shunyao; Xiu, Youcheng

doi:10.1016/j.biopha.2020.109830

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…Further studies are needed to investigate the effect of targeting CENPF and CIT as a possible therapeutic strategy to treat COVID-19. It is worth mentioning that the overexpression of CENPF and CIT, as is the case in this study, has been associated with different types of cancer such as cervical cancer, hepatocellular carcinoma, osteosarcoma, bladder cancer, and esophageal squamous cell carcinoma [49][50][51][52][53] . Targeting MYB may be also an alternative strategy to inhibit CENPF and indirectly control viral replication.…”

Section: Discussionsupporting

confidence: 57%

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

Samy

Maher

Abdelsalam

et al. 2022

Sci Rep

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COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus evolve, a complete comprehension of the disease and drug targets becomes a decisive duty. The Omicron variant, for example, has a notably high transmission rate verified in 155 countries. We performed integrative transcriptomic and network analyses to identify drug targets and diagnostic biomarkers and repurpose FDA-approved drugs for SARS-CoV-2. Upon the enrichment of 464 differentially expressed genes, pathways regulating the host cell cycle were significant. Regulatory and interaction networks featured hsa-mir-93-5p and hsa-mir-17-5p as blood biomarkers while hsa-mir-15b-5p as an antiviral agent. MYB, RRM2, ERG, CENPF, CIT, and TOP2A are potential drug targets for treatment. HMOX1 is suggested as a prognostic biomarker. Enhancing HMOX1 expression by neem plant extract might be a therapeutic alternative. We constructed a drug-gene network for FDA-approved drugs to be repurposed against the infection. The key drugs retrieved were members of anthracyclines, mitotic inhibitors, anti-tumor antibiotics, and CDK1 inhibitors. Additionally, hydroxyquinone and digitoxin are potent TOP2A inhibitors. Hydroxyurea, cytarabine, gemcitabine, sotalol, and amiodarone can also be redirected against COVID-19. The analysis enforced the repositioning of fluorouracil and doxorubicin, especially that they have multiple drug targets, hence less probability of resistance.

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Section: Discussionsupporting

confidence: 57%

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

Samy

Maher

Abdelsalam

et al. 2022

Sci Rep

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“…Knockdown of KIF23 resulted in marked inhibition of proliferation in gastric cancer [ 44 ]. Other DAGs, the silencing of which has been demonstrated to inhibit cell proliferation or increase apoptosis in other malignancies, include MLF1, MELTF, CIT, RRBP1, CHD7, and MEIS2 [ 45 , 46 , 47 , 48 , 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Activation of Oncogenic and Immune-Response Pathways Is Linked to Disease-Specific Survival in Merkel Cell Carcinoma

Sundqvist

Kilpinen

Böhling

et al. 2022

Cancers

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Background: Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine carcinoma of the skin with a poor prognosis. Improving the prognosis of MCC by means of targeted therapies requires further understanding of the mechanisms that drive tumor progression. In this study, we aimed to identify the genes, processes, and pathways that play the most crucial roles in determining MCC outcomes. Methods: We investigated transcriptomes generated by RNA sequencing of formalin-fixed paraffin-embedded tissue samples of 102 MCC patients and identified the genes that were upregulated among survivors and in patients who died from MCC. We subsequently cross-referenced these genes with online databases to investigate the functions and pathways they represent. We further investigated differential gene expression based on viral status in patients who died from MCC. Results: We found several novel genes associated with MCC-specific survival. Genes upregulated in patients who died from MCC were most notably associated with angiogenesis and the PI3K-Akt and MAPK pathways; their expression predominantly had no association with viral status in patients who died from MCC. Genes upregulated among survivors were largely associated with antigen presentation and immune response. Conclusion: This outcome-based discrepancy in gene expression suggests that these pathways and processes likely play crucial roles in determining MCC outcomes.

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“…CIT (Citron Rho-Interacting Serine/Threonine Kinase) functions in cell division ( 41 ). Recent studies indicate that CIT plays a key role in the development of human cancer, including colon cancer ( 42 ) and bladder cancer ( 43 ). FAM198B (Family With Sequence Similarity 198 Member B), also named GASK1B (Golgi Associated Kinase 1B), is located in the Golgi apparatus.…”

Section: Discussionmentioning

confidence: 99%

Identification of an integrated kinase-related prognostic gene signature associated with tumor immune microenvironment in human uterine corpus endometrial carcinoma

et al. 2022

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In the worldwide, uterine corpus endometrial carcinoma (UCEC) is the sixth most common malignancy in women, and the number of women diagnosed is increasing. Kinase plays an important role in the occurrence and development of malignant tumors. However, the research about kinase in endometrial cancer is still unclear. Here, we first downloaded the gene expression data of 552 UCEC patients and 23 healthy endometrial tissues from The Cancer Genome Atlas (TCGA), obtained 538 kinase-related genes from the previous literature, and calculated 67 differentially expressed kinases. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were referenced to identify multiple important biological functions and signaling pathways related to 67 differentially expressed kinases. Using univariate Cox regression and Least absolute shrinkage and selection operator (LASSO), seven kinases (ALPK2, CAMKV, TTK, PTK6, MAST1, CIT, and FAM198B) were identified to establish a prognostic model of endometrial cancer. Then, patients were divided into high- and low-risk groups based on risk scores. Receiver operating characteristic (ROC) curves were plotted to evaluate that the model had a favorable predictive ability. Kaplan–Meier survival analysis suggested that high-risk groups experienced worse overall survival than low-risk groups. qRT-PCR and ISH assays confirmed the consistency between predicted candidate genes and real sample contents. CIBERSORT algorithm and ssGSEA were adopted to investigate the relationship between this signature and tumor immune microenvironment, and revealed that in low- and high-risk groups, the types of tumor-infiltrating immune cells and the immune cell-related functions were significantly different. In summary, a seven-gene signature risk model has been constructed, and could accurately predict the prognosis of UCEC, which may offer ideas and breakthrough points to the kinase-associated development of UCEC.

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Down-regulation of CIT can inhibit the growth of human bladder cancer cells

Cited by 10 publications

References 24 publications

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

Activation of Oncogenic and Immune-Response Pathways Is Linked to Disease-Specific Survival in Merkel Cell Carcinoma

Identification of an integrated kinase-related prognostic gene signature associated with tumor immune microenvironment in human uterine corpus endometrial carcinoma

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