Down-Regulation of Circular RNA_000926 Attenuates Renal Cell Carcinoma Progression through miRNA-411–Dependent CDH2 Inhibition

Zhang, Dong; Yang, Xiaojie; Luo, Qidong; Fu, Delai; Li, Zhaolun; Zhang, Peng; Chong, Tie

doi:10.1016/j.ajpath.2019.06.016

Cited by 36 publications

(28 citation statements)

References 34 publications

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“…25 Downregulation of circ_001895 or circ_000926 impeded cell growth and invasion through targeting the miR-296-5p/SOX12 or miR-411/CDH2 axis in RCC cells. 26,27 In this report, the experimental results denoted that RCC cell proliferation, migration, invasion and EMT process were all suppressed with the inhibition of circ_0035483 expression. Glycolysis is a frequent metabolic pathway in the developing process of tumor cells, accompanied by the heavy consumption of glucose and production of lactate under aerobic condition.…”

Section: Discussionmentioning

confidence: 75%

Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation

Liu

Wang

Zhu

2021

CMAR

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Background: Renal cell carcinoma (RCC) that originates from the proximal renal tubules is the most common cancer of the human kidney. Increasing circRNA/miRNA/mRNA networks have been found in RCC regulation. This study will explore the regulatory relation of circular RNA (circRNA) circ_0035483, microRNA-31-5p (miR-31-5p) and high mobility group A1 (HMGA1). Methods: The levels of circ_0035483, miR-31-5p and HMGA1 were measured by real-time polymerase chain reaction (qRT-PCR) or Western blot. Cell proliferation was determined using Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell migration and invasion were assessed by transwell assay. HMGA1 and epithelial-mesenchymal transition (EMT)-related protein levels were quantified using Western blot. Glycolytic metabolism was evaluated by glucose consumption and lactate production. The interaction between targets was confirmed via dual-luciferase reporter, RNA immunoprecipitation (RIP) and RNA pull-down assays. In vivo experiment was performed through the establishment of xenograft models in mice. Results: Circ_0035483 expression was upregulated in RCC tissues and cells. The inhibitory effects on RCC cell proliferation, migration, invasion, EMT and glycolysis were induced after circ_0035483 was downregulated. MiR-31-5p was identified as a target of circ_0035483 and miR-31-5p upregulation was related to the function of circ_0035483 knockdown in RCC cells. Additionally, miR-31-5p targeted HMGA1 and inhibited the malignant behaviors of RCC cells by negatively regulating HMGA1. Moreover, HMGA1 expression was regulated by circ_0035483 via targeting miR-31-5p. Circ_0035483 also affected tumor growth in vivo by relying on the miR-31-5p/HMGA1 axis. Conclusion:These findings clarified that the tumor-promoting function of circ_0035483 in RCC was partly achieved by regulating the miR-31-5p/HMGA1 axis.

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Section: Discussionmentioning

confidence: 75%

Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation

Liu

Wang

Zhu

2021

CMAR

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“…Zhang et al concluded that miR-411 was targeted by circ_000926, and miR-411 depletion abolished the anti-tumor role of circ_000926 downregulation in RCC progression. 31 Another report declared that the expression of miR-411 was declined in RCC tissues and cells, and miR-411 enrichment significantly weakened the proliferation and migration of RCC cells. 32 All evidence mentioned above indicated that miR-411 was a tumor suppressor at least in RCC.…”

Section: Discussionmentioning

confidence: 99%

Circ_101341 Deteriorates the Progression of Clear Cell Renal Cell Carcinoma Through the miR- 411/EGLN3 Axis

Yue

Cui

Zhao

et al. 2020

CMAR

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“…In addition to E-cadherin, N-cadherin (also known as cadherin 2, CDH2), which is a mesenchymal marker, is differently expressed in RCC and EMT progression (Behnes et al, 2012;Alimperti and Andreadis, 2015). circ_000926 is highly expressed and may function as an miR-411 sponge to upregulate CDH2 expression, thereby facilitating EMT progression and leading to poor prognosis (Zhang et al, 2019).…”

Section: Emt-related Circular Rnasmentioning

confidence: 99%

Role of Circular RNA in Kidney-Related Diseases

Chen

Zhao

et al. 2021

Front. Pharmacol.

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The kidney is vital in maintaining fluid, electrolyte, and acid–base balance. Kidney-related diseases, which are an increasing public health issue, can happen to people of any age and at any time. Circular RNAs (circRNAs) are endogenous RNA that are produced by selective RNA splicing and are involved in progression of various diseases. Studies have shown that various kidney diseases, including renal cell carcinoma, acute kidney injury, and chronic kidney disease, are linked to circRNAs. This review outlines the characteristics and biological functions of circRNAs and discusses specific studies that provide insights into the function and potential of circRNAs for application in the diagnosis and treatment of kidney-related diseases.

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Down-Regulation of Circular RNA_000926 Attenuates Renal Cell Carcinoma Progression through miRNA-411–Dependent CDH2 Inhibition

Cited by 36 publications

References 34 publications

Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation

Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation

Circ_101341 Deteriorates the Progression of Clear Cell Renal Cell Carcinoma Through the miR- 411/EGLN3 Axis

Role of Circular RNA in Kidney-Related Diseases

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