Down-regulation of cellular protein heme oxygenase 1 inhibits proliferation of classical swine fever virus in PK-15 cells

Shi, Zhu‐Pei; Sun, Jiazhi; Guo, Huancheng; Yang, Zhilin; Ma, Zhiyong; Tu, Changchun

doi:10.1016/j.virusres.2013.01.012

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…HO-1 is known to be rapidly induced for cellular protection under various stresses, including many types of viral infection. Classical swine fever virus (CSFV) or human cytomegalovirus (HMCV) induces an increase in HO-1 expression [20,21]. Conversely, HIV, HCV and Bovine viral diarrhea virus infections are associated with a down-regulation in HO-1 expression [19,22,23].…”

Section: Resultsmentioning

confidence: 99%

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Kalamouni

Frumence

Bos

et al. 2018

Viruses

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Heme oxygenase-1 (HO-1), a rate-limiting enzyme involved in the degradation of heme, is induced in response to a wide range of stress conditions. HO-1 exerts antiviral activity against a broad range of viruses, including the Hepatitis C virus, the human immunodeficiency virus, and the dengue virus by inhibiting viral growth. It has been reported that HO-1 displays antiviral activity against the Zika virus (ZIKV) but the mechanisms of viral inhibition remain largely unknown. Using a ZIKV RNA replicon with the Green Fluorescent Protein (GFP) as a reporter protein, we were able to show that HO-1 expression resulted in the inhibition of viral RNA replication. Conversely, we observed a decrease in HO-1 expression in cells replicating the ZIKV RNA replicon. The study of human cells infected with ZIKV showed that the HO-1 expression level was significantly lower once viral replication was established, thereby limiting the antiviral effect of HO-1. Our work highlights the capacity of ZIKV to thwart the anti-replicative activity of HO-1 in human cells. Therefore, the modulation of HO-1 as a novel therapeutic strategy against ZIKV infection may display limited effect.

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Section: Resultsmentioning

confidence: 99%

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Kalamouni

Frumence

Bos

et al. 2018

Viruses

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“…HO-1 is rapidly induced in response to various stimuli such as oxidants, heat shock, and infection with microbial agents, including viruses. For virus infection, human cytomegalovirus (HCMV) and classical swine fever virus (CSFV) induced HO-1 expression 16 17 , and over expression of the HCV core-NS3 protein increased also HO-1 expression 18 . Consequently, it might be anticipated that HO-1 would be up-regulated in response to BVDV infection.…”

Section: Discussionmentioning

confidence: 99%

Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro

Zhang

et al. 2015

Sci Rep

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Viral cycle progression depends upon host-cell processes in infected cells, and this is true for bovine viral diarrhoea virus (BVDV), the causative agent of BVD that is a worldwide threat to the bovine industry. Heme oxygenase-1 (HO-1) is a ubiquitously expressed inducible isoform of the first and rate-limiting enzyme for heme degradation. Recent studies have demonstrated that HO-1 has significant antiviral properties, inhibiting the replication of viruses such as ebola virus, human immunodeficiency virus, hepatitis C virus, and porcine reproductive and respiratory syndrome virus. However, the function of HO-1 in BVDV infection is unclear. In the present study, the relationship between HO-1 and BVDV was investigated. In vitro analysis of HO-1 expression in BVDV-infected MDBK cells demonstrated that a decrease in HO-1 as BVDV replication increased. Increasing HO-1 expression through adenoviral-mediated overexpression or induction with cobalt protoporphyrin (CoPP, a potent HO-1 inducer), pre- and postinfection, effectively inhibited BVDV replication. In contrast, HO-1 siRNA knockdown in BVDV-infected cells increased BVDV replication. Therefore, the data were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction of HO-1 may be a useful prevention and treatment strategy against BVDV infection.

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“…(8) Some proteins involved in autophagy or apoptosis, such as BECN1, LC3 [83], NDP52 [84], and FHC [85], also could regulate CSFV replication. (9) Other proteins were also reported to be involved in the CSFV replication, such as FKBP8 [86], Jiv90 [87], HSP70 [88], HO-1 [89], and AIF1 [90].…”

Section: Host Proteins Whose Function Defect Exert Anti-csfv Effectsmentioning

confidence: 99%

Anti-Classical Swine Fever Virus Strategies

et al. 2021

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Classical swine fever (CSF), caused by CSF virus (CSFV), is a highly contagious swine disease with high morbidity and mortality, which has caused significant economic losses to the pig industry worldwide. Biosecurity measures and vaccination are the main methods for prevention and control of CSF since no specific drug is available for the effective treatment of CSF. Although a series of biosecurity and vaccination strategies have been developed to curb the outbreak events, it is still difficult to eliminate CSF in CSF-endemic and re-emerging areas. Thus, in addition to implementing enhanced biosecurity measures and exploring more effective CSF vaccines, other strategies are also needed for effectively controlling CSF. Currently, more and more research about anti-CSFV strategies was carried out by scientists, because of the great prospects and value of anti-CSFV strategies in the prevention and control of CSF. Additionally, studies on anti-CSFV strategies could be used as a reference for other viruses in the Flaviviridae family, such as hepatitis C virus, dengue virus, and Zika virus. In this review, we aim to summarize the research on anti-CSFV strategies. In detail, host proteins affecting CSFV replication, drug candidates with anti-CSFV effects, and RNA interference (RNAi) targeting CSFV viral genes were mentioned and the possible mechanisms related to anti-CSFV effects were also summarized.

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Down-regulation of cellular protein heme oxygenase 1 inhibits proliferation of classical swine fever virus in PK-15 cells

Cited by 12 publications

References 35 publications

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus

Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro

Anti-Classical Swine Fever Virus Strategies

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