Down-regulation of CD53 expression in Epinephelus coioides under LPS, poly (I:C), and cytokine stimulation

Hou, Chia-Yi; Lin, John Han-You; Lin, Shio Jean; Kuo, Wan-Ching; Lin, Han-Tso

doi:10.1016/j.fsi.2015.11.032

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…In fish, downregulation of CD53 is associated to increase susceptibility to pathogen invasion and inflammatory reactions (Hou et al 2016). These results suggest a conserved function for CD53 in evolution.…”

Section: Cd53 Deficiencymentioning

confidence: 79%

Central Cannabinoid Receptor

2018

Encyclopedia of Signaling Molecules

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Section: Cd53 Deficiencymentioning

confidence: 79%

Central Cannabinoid Receptor

2018

Encyclopedia of Signaling Molecules

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“…Referring to several published studies, we found that injection concentrations of 1 µg to 50 µg LPS and poly (I:C) per gram of fish body weight were sufficient to trigger an immune response in fish. We chose a moderate concentration by considering the weight and tolerance of the fish in this experiment [48][49][50]. Referring to the sampling time of related experiments, the samples were collected at 6 h and 48 h after the injection experiment to investigate the immune response of the yellow drum at the early and later periods of pathogen infection [48][49][50].…”

Section: Experimental Fishes and Injection Programmentioning

confidence: 99%

“…We chose a moderate concentration by considering the weight and tolerance of the fish in this experiment [48][49][50]. Referring to the sampling time of related experiments, the samples were collected at 6 h and 48 h after the injection experiment to investigate the immune response of the yellow drum at the early and later periods of pathogen infection [48][49][50]. Therefore, the experiment was divided into two parts: (1) The 6 h attack experiment: the experimental fishes were placed in 3 separate aquariums (80 × 60 × 40 cm) and 9 fishes per aquarium.…”

Section: Experimental Fishes and Injection Programmentioning

confidence: 99%

Spleen Transcriptome Profiling Reveals Divergent Immune Responses to LPS and Poly (I:C) Challenge in the Yellow Drum (Nibea albiflora)

Zhao

Zhang

Gao

et al. 2023

IJMS

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The yellow drum (Nibea albiflora) is a marine teleost fish with strong disease resistance, yet the understanding of its immune response and key functional genes is fragmented. Here, RNA-Seq was used to investigate the regulation pathways and genes involved in the immune response to infection with lipopolysaccharide (LPS) and polyinosinic-polycytidylic acid (poly (I:C)) on the spleen of the yellow drum. There were fewer differentially expressed genes (DEGs) in the LPS-infected treatment group at either 6 or 48 h. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were mainly significantly enriched in c5-branching dibasic acid metabolic and complement and coagulation cascades pathways. The yellow drum responded more strongly to poly (I:C) infection, with 185 and 521 DEGs obtained under 6 and 48 h treatments, respectively. These DEGs were significantly enriched in the Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Jak-STAT signaling pathway, NOD-like signaling pathway, and cytokine–cytokine receptor interaction. The key functional genes in these pathways played important roles in the immune response and maintenance of immune system homeostasis in the yellow drum. Weighted gene co-expression network analysis (WGCNA) revealed several important hub genes. Although the functions of some genes have not been confirmed, our study still provides significant information for further investigation of the immune system of the yellow drum.

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“…CD37 expression is highly increased in Atlantic salmons after a secondary viral infection ( 26 ). Conversely, treatment with several immune stimulators downregulate CD9, CD53, and CD63 expression in leukocytes from teleost fishes ( 27 , 28 ). The study of the innate defense mechanisms in non-mammalian vertebrates can give additional hints for the comprehension of vertebrate innate immunity.…”

Section: Introductionmentioning

confidence: 99%

Tetraspanins as Organizers of Antigen-Presenting Cell Function

2018

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Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger T-cell activation, proliferation, and differentiation, and lead to adaptive immune responses. After detection of microbial antigens through pattern recognition receptors (PRRs), APCs migrate to secondary lymphoid organs where antigen presentation to T lymphocytes takes place. Tetraspanins are membrane proteins that organize specialized membrane platforms, called tetraspanin-enriched microdomains, which integrate membrane receptors, like PRR and major histocompatibility complex class II (MHC-II), adhesion proteins, and signaling molecules. Importantly, through the modulation of the function of their associated membrane partners, tetraspanins regulate different steps of the immune response. Several tetraspanins can positively or negatively regulate the activation threshold of immune receptors. They also play a role during migration of APCs by controlling the surface levels and spatial arrangement of adhesion molecules and their subsequent intracellular signaling. Finally, tetraspanins participate in antigen processing and are important for priming of naïve T cells through the control of T-cell co-stimulation and MHC-II-dependent antigen presentation. In this review, we discuss the role of tetraspanins in APC biology and their involvement in effective immune responses.

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Down-regulation of CD53 expression in Epinephelus coioides under LPS, poly (I:C), and cytokine stimulation

Cited by 11 publications

References 41 publications

Central Cannabinoid Receptor

Central Cannabinoid Receptor

Spleen Transcriptome Profiling Reveals Divergent Immune Responses to LPS and Poly (I:C) Challenge in the Yellow Drum (Nibea albiflora)

Tetraspanins as Organizers of Antigen-Presenting Cell Function

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