Down-modulation of lymphoproliferation and interferon-gamma production by beta-glucan derived from Saccharomyces cerevisiae

Pelizon, A. C.; Kaneno, Ramon; Soares, Ana Flávia; Meira, Domingos Alves; Sartori, Alexandrina

doi:10.1590/s0074-02762003000800019

Cited by 14 publications

(11 citation statements)

References 24 publications

(21 reference statements)

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“…Beta-glucans are known immunomodulators. [5][6][7] Glucans typically mediate innate immune activating properties, such as natural killer cell and macrophage activation, and beta-glucans are generally considered pro-inflammatory in nature. 8,9 In contrast to pure beta-glucans and yeast cell wall preparations, complex fungal-derived products present a highly complex profile of bioactive compounds to the immune system.…”

Section: Introduction Imentioning

confidence: 99%

Anti-Inflammatory Properties of a Dried FermentateIn VitroandIn Vivo

Jensen

Carter

Reeves³

et al. 2015

Journal of Medicinal Food

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The aim of this study was to document anti-inflammatory properties of a dried fermentate derived from Saccharomyces cerevisiae (EpiCor Ò ), hereafter referred to as dried fermentate in vitro using cell-based bioassays, and in vivo using a skin irritation model in healthy humans. In vitro testing involved parallel assessment of primary human polymorphonuclear (PMN) cell formation of reactive oxygen species (ROS) and migration toward the inflammatory mediator Leukotriene B4. In vivo evaluation used a single-blind placebo-controlled design, where dermal histamine-induced inflammation was used as a model for the complex intercellular signals involved in the initiation, escalation, and resolution of the inflammatory response. Microvascular blood perfusion was evaluated using noninvasive laser Doppler probes applied to the inner forearms of 12 healthy human subjects, where parallel sites were treated with either dried fermentate or saline (placebo). Subjective scores of dermal irritation were also collected. Treatment of PMN cells in vitro resulted in reduced ROS formation and migratory activity toward Leukotriene B4. Clinical results demonstrated significantly reduced microvascular inflammatory responses to histamine-induced skin inflammation, and significantly reduced subjective scores of irritation at the inflamed sites treated with dried fermentate compared with the sites treated with placebo (P < .05). Treatment of inflammatory cells in vitro with dried fermentate resulted in reduced inflammatory responses. This was confirmed in vivo, suggesting that the dried fermentate facilitates the resolution of inflammatory responses. The effects using a topical skin model suggest that similar events may happen when the dried fermentate is introduced across mucosal membranes after consumption.KEY WORDS: reactive oxygen species polymorphonuclear migration laser Doppler histamine blood perfusion leukotriene B4

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Section: Introduction Imentioning

confidence: 99%

Anti-Inflammatory Properties of a Dried FermentateIn VitroandIn Vivo

Jensen

Carter

Reeves³

et al. 2015

Journal of Medicinal Food

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“…Beta-glucan from Saccharomyces cerevisiae possesses the strong ability to stimulate immune system [25]. Beta-glucan possesses also free radical scavenging activity and ability to ameliorate inflammatory conditions [26]. Moreover, results of Saluk et al [27,28] showed that beta-glucan possesses significant defence properties against the strong physiological oxidants -peroxynitrite or hydroperoxide induced lipid peroxidation in human blood platelets or plasma.…”

Section: Introductionmentioning

confidence: 99%

Beta-glucan from Saccharomyces cerevisiae reduces plasma lipid peroxidation induced by haloperidol

Dietrich‐Muszalska

Olas

Kontek

et al. 2011

International Journal of Biological Macromolecules

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“…Peroxidation of LDL lipids seems to be probably mechanism because protein-bound lipid oxidation products have been detected in atherosclerotic lesions [54], and lipid soluble antioxidants inhibit atherosclerosis in animal models [55]. There is now a large body of evidence that supplementation of (1→3)-␤-d-glucan provides favourable biological effects on mammals such as the decrease of cholesterol and triglyceride level and the normalization of blood sugar concentration [56,57].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years various publications have described its strong positive effects on the immune system, resulting in antibacterial, wound-healing, and antitumor activities [10,56,57,67] suggested also antioxidative activity of this biopolymer [12]. The exploration of antioxidants is of great interest because they are able to protect living organisms from the attack of reactive oxygen species and in this way to decrease the risk of several degenerative diseases [50].…”

Section: Discussionmentioning

confidence: 99%