Down But Not Out

Gilbert, Jeffrey S.; Gillham, Haley; Regal, Jean F.

doi:10.1161/hypertensionaha.114.03477

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Plasma ET-1concentrations during preeclampsia was approximately two- to three-times higher than normal levels, and ET-1 has significant long-term effects on arterial pressure regulation [8-10]. However, some studies have reported that there was no elevation in plasma endothelin in preeclampsia patients [11]. In addition, ET-1 is considered to be involved in the progression of preeclampsia rather than the initiation of the disease; thus, the exact role of endothelin is unknown [7].…”

Section: Introductionmentioning

confidence: 99%

Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension

Sun

Zhang

Chen

et al. 2017

Cell Physiol Biochem

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Background/Aims: Studies have shown that a change in endothelin receptor expression in the artery is related to pregnancy-induced hypertension (PIH). However, the mechanism underlying this change remains unclear. Methods: To test whether the distribution of endothelin receptor type-A (ET_AR) and type-B (ET_BR) plays an important role in PIH, a reduction of uterine perfusion pressure (RUPP) rat model was used to mimic some of the features of PIH; the resulting variable endothelin receptor expression was investigated in the media and intima of the aorta. Single vascular smooth muscle cells (VSMCs) were isolated from RUPP and normal pregnant (NP) rats to study the effect of ET_AR and ET_BR in smooth muscle cells. Results: Compared with NP rats, RUPP rats had a significant redistribution of ET_BR expression in the intima and media, while there was no significant difference in ET_AR expression between the two groups. ET_BR upregulation in VSMCs enhanced cellular contraction and contributed to PIH. The TNF-α plasma levels in RUPP rats were two-fold higher than those of NP rats, which upregulated the expression of ET_BR in VSMCS through the NF-κB pathways in RUPP rats. Conclusion: Redistribution of ET_BR between the media and intima played an important role in the pathogenesis of PIH.

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Section: Introductionmentioning

confidence: 99%

Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension

Sun

Zhang

Chen

et al. 2017

Cell Physiol Biochem

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“…The biological effects of ET-1 are mediated by two G protein-coupled receptors, ETA receptor (ETAR) and ETB receptor (ETBR) [ 8 , 9 ]. ETAR promotes vasoconstriction, cell growth, adhesion and thrombosis, while ETBR promotes vasodilation [ 10 , 11 , 12 ]. Endothelin receptor antagonists have been developed for the treatment of multiple cardiovascular diseases, such as hypertension and systemic sclerosis [ 10 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…ETAR promotes vasoconstriction, cell growth, adhesion and thrombosis, while ETBR promotes vasodilation [ 10 , 11 , 12 ]. Endothelin receptor antagonists have been developed for the treatment of multiple cardiovascular diseases, such as hypertension and systemic sclerosis [ 10 , 13 , 14 , 15 ]. Moreover, they also show therapeutic action for glaucoma [ 16 ], preeclampsia [ 17 ], diabetic kidney disease [ 18 ] and ovarian tumors [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of Dual ETA/ETB Receptor Antagonists from Traditional Chinese Herbs through in Silico and in Vitro Screening

Wang

Zhang

Liu

et al. 2016

IJMS

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Endothelin-1 receptors (ETAR and ETBR) act as a pivotal regulator in the biological effects of ET-1 and represent a potential drug target for the treatment of multiple cardiovascular diseases. The purpose of the study is to discover dual ETA/ETB receptor antagonists from traditional Chinese herbs. Ligand-and structure-based virtual screening was performed to screen an in-house database of traditional Chinese herbs, followed by a series of in vitro bioassay evaluation. Aristolochic acid A (AAA) was first confirmed to be a dual ETA/ETB receptor antagonist based intracellular calcium influx assay and impedance-based assay. Dose-response curves showed that AAA can block both ETAR and ETBR with IC 50 of 7.91 and 7.40 µM, respectively. Target specificity and cytotoxicity bioassay proved that AAA is a selective dual ETA/ETB receptor antagonist and has no significant cytotoxicity on HEK293/ETAR and HEK293/ETBR cells within 24 h. It is a feasible and effective approach to discover bioactive compounds from traditional Chinese herbs using in silico screening combined with in vitro bioassay evaluation. The structural characteristic of AAA for its activity was especially interpreted, which could provide valuable reference for the further structural modification of AAA.

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Circ_0063517 acts as ceRNA, targeting the miR-31-5p-ETBR axis to regulate angiogenesis of vascular endothelial cells in preeclampsia

Fan

et al. 2020

Life Sciences

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Down But Not Out

Cited by 3 publications

References 12 publications

Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension

Reduction of Uterine Perfusion Pressure Induced Redistribution of Endothelin Receptor Type-B Between the Intima and Media Contributes to the Pathogenesis of Pregnancy-Induced Hypertension

Discovery of Dual ETA/ETB Receptor Antagonists from Traditional Chinese Herbs through in Silico and in Vitro Screening

Circ_0063517 acts as ceRNA, targeting the miR-31-5p-ETBR axis to regulate angiogenesis of vascular endothelial cells in preeclampsia

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