Dowling-Degos disease (reticulate pigmented anomaly of the flexures) is an autosomal dominant condition

Abstract

SUMMARY A family is described in which eleven members were affected by the Dowling‐Degos disease, which appeared to be transmitted as an autosomal dominant.

Generalized Dowling-Degos Disease: Case Reports

“…Dowling-Degos disease (DDD) is a rare autosomal dominant trait characterized by numerous, symmetrical, progressive and pigmented macules over the axillae, groins, face, neck, arms and trunk as well as scattered comedo-like lesions (dark dot follicles) and pitted acneiform scars1-3. The disorder usually appears and/or worsens after puberty.…”

Generalized Dowling-Degos disease

“…[1][2][3] Pigmentation on the back of hands is occasionally found having overlap features with reticulate acropigmentation of Kitamura (RAPK). [4][5][6][7][8][9] Rarely, hypopigmented macules or papules resembling dyschromatosis symmetrica hereditaria (DSH) or dyschromatosis universalis hereditaria (DUH) have been reported.…”

Galli-Galli disease is an acantholytic variant of Dowling-Degos disease: Additional genetic evidence in a German family

“…Comedo-like lesions on the back or neck, pitted perioral scars, and hypopigmented macules are also described. 2 Histopathologically, DDD shows acanthotic elongation of rete ridges in conjunction with basal hyperpigmentation. Galli-Galli disease (GGD) is an eponym introduced in 1982 to describe a skin disease in two affected brothers with reticulated hyperpigmentation and erythematous lichenoid papules resembling DDD, but with the histopathologic finding of prominent acantholysis.…”