Dowling-Degos disease: An association with hidradenitis suppurativa

Abstract

Dowling-Degos disease is one of the genodermatoses presenting with acquired reticulate pigmentation of the flexures, black-dot papules, and pitted scars. Numerous associated conditions and multiple variants of the disease have been reported in the literature. Several gene mutations play a role in the pathogenesis of the disease giving rise to multiple phenotypic expressions. Herein, we discuss a case in three generations of a family affected with the disease and shed light on the associations and various expressions of the disease.

Co-existent Dowling–Degos disease, reticulate acropigmentation of Kitamura, and acropigmentation of Dohi in two generations: An overlap or concept of a single disease?

“…DDD, first described by Dowling in 1938 and by Degos in 1954, often has a late-onset presentation of reticulate, pigmented lesions on flexures, that is, the axillae, groin, and neck, with comedo-like lesions and pitted perioral scars [2]. In addition, DDD has reportedly been associated with other diseases, such as hidradenitis suppurativa, multiple keratoacanthomas, and squamous cell carcinoma [3][4][5].…”

A case of delayed diagnosis of Dowling Degos disease

“…DDD is characterized by acquired reticulate pigmentation of the flexures, neck, groin, wrist, face, vulva, and scrotum. Other associated skin manifestations are pitted, perioral, acneiform scars, comedo-like, hyperkeratotic papules, epidermal, trichilemmal cysts, and hidradenitis suppurativa [2,3]. The onset of the disease is typically after puberty and…”