Doubling time of circulating cea and its relation to survival of patients with recurrent colorectal cancer

Staab, Hans-Jürgen; Anderer, F. A.; Hornung, A.; Stumpf, E; Fischer, Rainer

doi:10.1038/bjc.1982.270

Cited by 66 publications

(28 citation statements)

References 6 publications

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“…Similarly, serial studies of sporadic colorectal tumor patients have indicated that the transition from large adenoma to carcinoma takes Ϸ15 years (11). Our estimates are also consistent with the long doubling times of tumors determined by serial radiologic studies or serial measurements of the CEA serum biomarker (10,12,32,33). Such studies have indicated mean doubling times that are generally 2-4 months in metastases and much longer in adenomas and carcinomas.…”

Section: Discussionsupporting

confidence: 75%

Comparative lesion sequencing provides insights into tumor evolution

Jones

Chen

Parmigiani

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

742

631

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We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes Ϸ17 years for a large benign tumor to evolve into an advanced cancer but <2 years for cells within that cancer to acquire the ability to metastasize; (ii) it requires few, if any, selective events to transform a highly invasive cancer cell into one with the capacity to metastasize; (iii) the process of cell culture ex vivo does not introduce new clonal mutations into colorectal tumor cell populations; and (iv) the rates at which point mutations develop in advanced cancers are similar to those of normal cells. These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis.cancer genetics ͉ colorectal cancer ͉ metastasis ͉ stem cells

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Section: Discussionsupporting

confidence: 75%

Comparative lesion sequencing provides insights into tumor evolution

Jones

Chen

Parmigiani

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

742

631

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“…There was a close correlation between survival and CEA doubling times for untreated liver metastasis. CEA doubling line has been claimed to be a good index of tumour growth rate (Stabb et al, 1982). In our study, we found that the CEA doubling times in hCG-positive large bowel cancers were significantly shorter than those in hCG-negative cancers, suggesting that hCG-positive carcinomas have higher proliferative activity and higher growth rates.…”

Section: Discussionsupporting

confidence: 48%

Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

Yamaguchi

Ishida²,

Nishimura³

et al. 1989

Br J Cancer

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Summary The presence of human chorionic gonadotropin in large bowel cancers was studied immunohistochemically using an immunoperoxidase technique. HCG-positive tumour cells were present in 42 of 194 adenocarcinomas examined (22.0% of colon cancer and 21.2% of rectal cancers). On histological grading, the hCG-positive rate tended to rise as the degree of differentiation decreased. HCG was detected more frequently in cancers invading the total bowel wall (27%) than in those invading the partial wall (17.1%). Lymph node, liver or peritoneal metastases were present more frequently in hCG-positive tumours than in hCG-negative tumours. Furthermore, there was an intimate correlation between the presence of hCG-positive tumour cells and CEA doubling times in nine cases with untreated liver metastasis. The survival rate for patients with tissue hCG-positive cells was lower than for those with hCG-negative tumours. Thus, the presence of tissue hCG in colorectal cancers may be a biological marker of prognostic significance.

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“…Thereafter, serum CEA-dt level was also reported to strongly correlate with the survival of patients with recurrent colorectal cancer [21]. Onodera et al [31] reported that CEA-dt reflects the rate of growth and is the most powerful determinant, while it also correlates with survival, more closely than the CEA level.…”

Section: Discussionmentioning

confidence: 99%

“…Tanaka et al [20] reported that the tumor doubling time of a liver metastasis from colorectal cancer was the most reliable risk factor for postoperative recurrence in the remnant liver and poor prognosis. Staab et al [21] stated that doubling time of carcinoembryonic antigen (CEA-dt) was strongly correlated with tumor doubling time. Koga et al [22] reported that CEA-dt is a prognostic factor after a hepatectomy of liver metastasis from colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

Doubling Time of Carcinoembryonic Antigen Is a Significant Prognostic Factor after the Surgical Resection of Locally Recurrent Rectal Cancer

Noura¹,

Ohue²,

Seki³

et al. 2008

Dig Surg

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Background: Patients undergoing a curative rectal cancer resection have a risk of developing locoregional recurrence. A curative resection for local recurrence is the option of improvement in prognosis. However, a curative resection is sometimes too invasive and should be considered in selected patients. Methods: A total of 43 patients with locally recurrent rectal cancer who had been treated by operation between 1989 and 2007 were retrospectively reviewed and the factors, including doubling time of carcinoembryonic antigen (CEA-dt), were analyzed. Results: The 5-year overall survival rate after the operation for local recurrence was 50.8%. Gender, presence of distant metastasis, tumor size, CEA-dt and curability were found to be significant prognostic factors. A multivariate analysis demonstrated the presence of distant metastasis, CEA-dt and tumor size to be significant prognostic factors for overall survival. The 5-year overall survival rates of patients with a CEA-dt ≧150 days and a tumor size <5 cm were 76.9%. Conclusions: The tumor size and CEA-dt were useful prognostic factors that were recognizable before surgery. Patients with locally recurrent rectal cancer with a CEA-dt ≧150 days and a recurrent tumor size <5 cm are considered to be good candidates for surgery.

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Doubling time of circulating cea and its relation to survival of patients with recurrent colorectal cancer

Cited by 66 publications

References 6 publications

Comparative lesion sequencing provides insights into tumor evolution

Comparative lesion sequencing provides insights into tumor evolution

Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis

Doubling Time of Carcinoembryonic Antigen Is a Significant Prognostic Factor after the Surgical Resection of Locally Recurrent Rectal Cancer

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