Doubling the omeprazole dose (40 mg b.d. vs. 20 mg b.d.) in dual therapy with amoxycillin increases the cure rate of <i>Helicobacter pylori</i> infection in duodenal ulcer patients

Labenz, Joachim; Beker, J. A.; Dekkers, C. P. M.; Farley, A; Klör, Hans‐Ulrich; Jönsson, Andreas

doi:10.1046/j.1365-2036.1997.00169.x

Cited by 22 publications

(15 citation statements)

References 27 publications

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“…improve its ef cacy. However, eradication rates of such regimens have varied widely (67,68), suggesting that dual therapy with only one antimicrobial may not be suf cient to cure H. pylori infection. Given these collective ndings, 45.8% indicate that it should not be used.…”

Section: Discussionmentioning

confidence: 99%

Pooled Analysis on the Efficacy of the Second-line Treatment Regimens for Helicobacter pylori Infection

Hojo

Miwa²,

Nagahara³

et al. 2001

Scandinavian Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Pooled Analysis on the Efficacy of the Second-line Treatment Regimens for Helicobacter pylori Infection

Hojo

Miwa²,

Nagahara³

et al. 2001

Scandinavian Journal of Gastroenterology

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“…In earlier studies, a pH‐enhancing effect of H. pylori infection was established, and achieving a higher pH by increasing the dose of proton pump inhibitor was associated with higher H. pylori eradication rates 60 , . 61 The proton pump inhibitors metabolized mainly by the CYP2C19 in the liver are affected by genotype status. Poor metabolizers of the enzyme show better eradication rates, whereas extensive metabolizers benefit from higher doses of the proton pump inhibitor and antibiotics 62 .…”

Section: Treatment Issues In Specialist Care and Novel Approaches To mentioning

confidence: 99%

Treatment of Helicobacter pylori infection and factors influencing eradication

Qasim

O’Moráin

2002

Aliment Pharmacol Ther

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Currently available Helicobacter pylori eradication therapies are considered very effective and safe. The most recent eradication guidelines proposed in the Maastricht 2‐2000 Consensus Report recommend the use of proton pump inhibitors (standard b.d.) along with clarithromycin (500 mg b.d.) and amoxycillin (1000 mg b.d.) or metronidazole (500 mg b.d.) for a minimum of 7 days. The combination of amoxycillin and clarithromycin is preferred because it may favour best results with a second‐line proton pump inhibitor quadruple therapy. The recommended second‐line therapy includes a combination of a proton pump inhibitor (standard b.d.) with bismuth salt (subsalicylate/subcitrate 120 mg q.d.s.), metronidazole (500 mg t.d.s.), and tetracycline (500 mg q.d.s.) for a minimum of 7 days. Extended proton pump inhibitor‐based triple therapy can be used if bismuth is not available. Specialists should manage subsequent failures. Based on direct and indirect evidence from well‐designed studies and clinical experience, eradication is recommended in gastric and duodenal ulcers, MALToma, atrophic gastritis, postgastric cancer resection, and in first‐degree relatives of gastric cancer patients. The most common reason for treatment failure is poor compliance with eradication guidelines. Antibiotic resistance may be a significant factor in certain geographical areas. Proton pump inhibitors are an integral part of the eradication regimens as proved by meta‐analyses of clinical trials. Novel agents used in secondary failure are few and depend on the use of new antibiotics. The role of H. pylori‐specific antibiotics, probiotics, and vaccines is not established as yet. Widespread acceptance of the eradication guidelines should be regarded as the single most important factor in eradication success.

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“…Optimum dose of PPI The dose of PPI required in amoxycillin dual therapy is important, with increasing acid suppression leading to greater efficacy (5). A review and meta-analysis of the literature was performed to evaluate whether the dose of PPI was also important in clarithromycin- In three RCTs (17)(18)(19), 378 patients were evaluated with single versus double standard dose PPI in clarithromycin and metronidazole (PCM) regimens.…”

Section: Optimum Dose and Duration Of Ppi In Clarithromycin-based Thementioning

confidence: 99%

How Can the Current Strategies for Helicobacter pylori Eradication Therapy be Improved?

Ford

Martin

2003

Canadian Journal of Gastroenterology and Hepatology

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Doubling the omeprazole dose (40 mg b.d. vs. 20 mg b.d.) in dual therapy with amoxycillin increases the cure rate of Helicobacter pylori infection in duodenal ulcer patients

Cited by 22 publications

References 27 publications

Pooled Analysis on the Efficacy of the Second-line Treatment Regimens for Helicobacter pylori Infection

Pooled Analysis on the Efficacy of the Second-line Treatment Regimens for Helicobacter pylori Infection

Treatment of Helicobacter pylori infection and factors influencing eradication

How Can the Current Strategies for Helicobacter pylori Eradication Therapy be Improved?

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