DoubleSlicing: A non-iterative single profile multi-exponential curve resolution procedure

Andrade, Letícia; Micklander, Elisabeth; Farhat, Imad A.; Bro, Rasmus; Engelsen, Søren Balling

doi:10.1016/j.jmr.2007.09.018

Cited by 14 publications

(8 citation statements)

References 15 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This procedure of converting the relaxation curve into three-way data may appear to be pointless at first glance, but it enables the use of threeway mathematical methods such as direct trilinear decomposition [DTLD (20)], which has some very attractive features. Andrade et al (18) tested the performance of Doubleslicing against existing methods and found that it was accurate in estimating relaxation times and that it outperformed exponential fitting by a factor of 4 with regard to computation time. The speed advantage is desirable when large data sets are analyzed.…”

Section: Nmr Data Analysis By Doubleslicing Time Domain Lf-nmrmentioning

confidence: 99%

“…In the present study Doubleslicing was performed similar to the method of Andrade et al (18). To validate that the relaxation curves were resolved into the actual number of exponentials and not under-or overfitting, an extensive range of diagnostic criteria had to be fulfilled.…”

Section: Nmr Data Analysis By Doubleslicing Time Domain Lf-nmrmentioning

confidence: 99%

“…A new exponential curve-fitting method called Doubleslicing was introduced by Micklander et al (12) to assist in the determination of water populations. Andrade et al (18) tested the performance of Doubleslicing against existing methods and found that it was accurate in estimating relaxation times and that it outperformed exponential fitting by a factor of 4 with regard to computation time.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ ¹H NMR Relaxation Study

Hansen

Rinnan²,

Engelsen³

et al. 2009

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

The objective of this study was to monitor rennet-induced milk gel formation and mechanically induced gel syneresis in situ by low-field NMR. pH, temperature, and gel firmness at cutting time were varied in a factorial design. The new curve-fitting method Doubleslicing revealed that during coagulation two proton populations with distinct transverse relaxation times (T2,1=181, T2,2=465 ms) were present in fractions (f1=98.9%, f2=1.1%). Mechanical cutting of the gel in the NMR tube induced macrosyneresis, which led to the appearance of an additional proton population (T2,3=1500-2200 ms) identified as whey. On the basis of NMR quantification of whey water the syneresis rate was calculated and found to be significantly dependent on pH and temperature.

show abstract

Section: Nmr Data Analysis By Doubleslicing Time Domain Lf-nmrmentioning

confidence: 99%

Section: Nmr Data Analysis By Doubleslicing Time Domain Lf-nmrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ ¹H NMR Relaxation Study

Hansen

Rinnan²,

Engelsen³

et al. 2009

J. Agric. Food Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Resolving the such data into individual components is very important for characterizing the sample. However, this problem is ill-conditioned and the results strongly depend on the quality of the initial relaxation curve measurement making the solutions difficult to interpret and validate [6]. In this context dense sampling of a relaxation curve improves the ability to resolve such data and extract the underlying characteristic relaxation times.…”

Section: Methods and Instrumentsmentioning

confidence: 99%

Magnetic Resonance Relaxometry at Low and Ultra Low Fields

et al. 2010

View full text Add to dashboard Cite

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are ubiquitous tools in science and medicine. NMR provides powerful probes of local and macromolecular chemical structure and dynamics. Recently it has become possible and practical to perform MR at very low fields (from 1 μT to 1 mT), the so-called ultra-low field (ULF) regime. Pulsed pre-polarizing fields greatly enhance the signal strength and allow flexibility in signal acquisition sequences. Improvements in SQUID sensor technology allow ultra-sensitive detection in a pulsed field environment. In this regime the proton Larmor frequencies (1 Hz – 100 kHz) of ULF MR overlap (on a time scale of 10 μs to 100 ms) with “slow” molecular dynamic processes such as diffusion, intra-molecular motion, chemical reactions, and biological processes such as protein folding, catalysis and ligand binding. The frequency dependence of relaxation at ultra-low fields may provide a probe for biomolecular dynamics on the millisecond timescale (protein folding and aggregation, conformational motions of enzymes, binding and structural fluctuations of coupled domains in allosteric mechanisms) relevant to host-pathogen interactions, biofuels, and biomediation. Also this resonance-enhanced coupling at ULF can greatly enhance contrast in medical applications of ULF-MRI resulting in better diagnostic techniques. We have developed a number of instruments and techniques to study relaxation vs. frequency at the ULF regime. Details of the techniques and results are presented. Ultra-low field methods are already being applied at LANL in brain imaging, and detection of liquid explosives at airports. However, the potential power of ultra-low field MR remains to be fully exploited.

show abstract

“…Figure 5 shows a graphical representation for the creation of these two proportional data sets from single decay experiment. 66 Recently, Andrade et al 67 have developed the doubleslicing method, in which the power slicing methodology is applied along both rows and columns of the original data set. 61 It has been shown that the way the data set is split affects the accuracy and precision of DECRA.…”

Section: Direct Exponential Curve Resolution Algorithmmentioning

confidence: 99%

Multiway Data Analysis: Eigenvector-Based Methods

Ferré

Boqué

Faber³

2009

Comprehensive Chemometrics

View full text Add to dashboard Cite

DoubleSlicing: A non-iterative single profile multi-exponential curve resolution procedure

Cited by 14 publications

References 15 publications

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ ¹H NMR Relaxation Study

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ ¹H NMR Relaxation Study

Magnetic Resonance Relaxometry at Low and Ultra Low Fields

Multiway Data Analysis: Eigenvector-Based Methods

Contact Info

Product

Resources

About

DoubleSlicing: A non-iterative single profile multi-exponential curve resolution procedure

Cited by 14 publications

References 15 publications

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ 1H NMR Relaxation Study

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ 1H NMR Relaxation Study

Magnetic Resonance Relaxometry at Low and Ultra Low Fields

Multiway Data Analysis: Eigenvector-Based Methods

Contact Info

Product

Resources

About

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ ¹H NMR Relaxation Study

Effect of Gel Firmness at Cutting Time, pH, and Temperature on Rennet Coagulation and Syneresis: An in situ ¹H NMR Relaxation Study